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| 1 | Transposon mouse models to elucidate the genetic mechanisms of hepatitis B viral induced hepatocellular carcinoma显示文摘The major type of human liver cancer is hepatocellular carcinoma(HCC), and there are currently many risk factors that contribute to this deadly disease. The majority of HCC occurrences are associated with chronic hepatitis viral infection, and hepatitis B viral(HBV) infection is currently a major health problem in Eastern Asia. Elucidating the genetic mechanisms associated with HBV-induced HCC has been difficult due to the heterogeneity and genetic complexity associated with this disease. A repertoire of animal models has been broadly used to study the pathophysiology and to develop potential treatment regimens for HBVassociated HCC. The use of these animal models has provided valuable genetic information and has been an important contributor to uncovering the factors involved in liver malignant transformation, invasion and metastasis. Recently, transposon-based mouse models are becoming more widely used in liver cancer research to interrogate the genome by forward genetics and also used to validate genes rapidly in a reverse genetic manner. Importantly, these transposon-based rapid reverse genetic mouse models could become crucial in testing potential therapeutic agents before proceeding to clinical trials in human. Therefore, this review will cover the use of transposon-based mouse models toaddress the problems of liver cancer, especially HBVassociated HCC occurrences in Asia. | Amy P Chiu Barbara R Tschida Lilian H Lo Branden S Moriarity Dewi K Rowlands David A Largaespada Vincent W Keng | 2015 | World Journal of Gastroenterology2015，21，42： | 2 |
| 2 | HIF-1α is required for solid tumor formation and embryonic vascularization显示文摘 | Ryan H E Lo J Johnson R S | 1998 | EMBO J1998，17，11： | 2 |
| 3 | Sex-specific differences in white matter microvascular integrity after ischaemic stroke显示文摘background and purpose Functional outcomes after ischaemic stroke are worse in women,despite adjusting for differences in comorbidities and treatment approaches.White matter microvascular integrity represents one risk factor for poor long-term functional outcomes after ischaemic stroke.The aim of the study is to characterise sex-specific differences in microvascular integrity in individuals with acute ischaemic stroke.Methods A retrospective analysis of subjects with acute ischaemic stroke and brain MRI with diffusion-weighted(DWI)and dynamic-susceptibility contrast-enhanced(DSC)perfusion-weighted imaging obtained within 9 hours of last known well was performed.In the hemisphere contralateral to the acute infarct,normal-appearing white matter(NAWM)microvascular integrity was measured using the K_(2) coefficient and apparent diffusion coefficient(ADC)values.Regression analyses for predictors of K_(2) coefficient,DWI volume and good outcome(90-day modified Rankin scale(mRS)score<2)were performed.results 105 men and 79 women met inclusion criteria for analysis.Despite no difference in age,women had increased NAWM K_(2) coefficient(1027.4 vs 692.7×10^(-6)/s;p=0.006).In women,atrial fibrillation(β=583.6;p=0.04)and increasing NAWM ADC(β=4.4;p=0.02)were associated with increased NAWM K_(2) coefficient.In multivariable regression analysis,the K_(2) coefficient was an independent predictor of DWI volume in women(β=0.007;p=0.01)but not men.Conclusions In women with acute ischaemic stroke,increased NAWM K_(2) coefficient is associated with increased infarct volume and chronic white matter structural integrity.Prospective studies investigating sex-specific differences in white matter microvascular integrity are needed. | Mark R Etherton Ona Wu Pedro Cougo Svetlana Lorenzano Hua Li Lisa Cloonan Mark J R J Bouts Arne Lauer Ken Arai Eng H Lo Steve K Feske Karen L Furie Natalia S Rost | 2019 | Stroke & Vascular Neurology2019，4，4： | 2 |
| 4 | White spot syndrome baculovirus(WSBV) detected in cultured and captured shrimp, crabs and other arthropods 显示文摘 | Lo C F Ho C H Peng S E | 1996 | Dis Aquat Org1996，27，： | 1 |
| 5 | Vanillin inhibits matrix metalloproteinase-9 expression through down-regulation of nuclear factor-kappaB signaling pathway in human hepatoeellular carcinoma cells显示文摘 | Liang J A Wu S L Lo H Y | 2009 | Mol Pharmacol2009，75，1： | 1 |
| 6 | Chaos and control of discrete dynamic traffic model显示文摘 | Lo S C Cho H J | 2005 | Journal of the Franklin Institute2005，342，7： | 1 |
| 7 | Time domain buffeting analysis of suspension bridge subjected to turbulent wind with effective action angle显示文摘 | Ding Q Lee P K K Lo S H | 2000 | Journal of Sound and Vibration2000，233，2： | 1 |
| 8 | Fast delaunay triangulation in three dimensions显示文摘 | Borouchaki H Lo S H | 1995 | Computer Methods in Applied Mechanics and Engineering1995，128，12： | 1 |
| 9 | Characteristics of the Tatun Volcanic Erupptions,North Taiwan:impplications for a cauldron formation and Volcanic evolution显示文摘 | SONF S R TSAO S LO H J | | 0，，： | 1 |
| 10 | Global update on the susceptibility of human influenza viruses to neuraminidase inhibitors, 2012-2013显示文摘 | Meijer A Rebelo-de-Andrade H Correia V Besselaar T Drager-Dayal R Fry A Gregory V Gubareva L Kageyama T Laekenby A Lo J Odagiri T Pere- yaslov D Siqueira M M Takashita E Tashiro M Wang D Wong S Zhang W Daniels R S Hurt A C | 2014 | An- tiviral Research2014，110，： | 1 |
| 11 | Application of evolutionary neural network method in predicting pollutant levels in downtown area of Hong Kong显示文摘 | FAN H Y LO S M | 2003 | Neuro computing2003，51，1： | 1 |
| 12 | Assessment of heavy metal cations in sediments of Shing Mun River,Hang Kong显示文摘 | Chua H Lo W | 2001 | Environment International2001，26，： | 1 |
| 13 | Generating quadrilateral elements on plane and over curved surfaces显示文摘 | LO S H | 1989 | Comput Struct1989，31，： | 1 |
| 14 | Diaehronous uplift of the Tibetan Plateau starting 40 Myr ago显示文摘 | Chung S L Lo C H Lee T Y | 1998 | Nature1998，394，： | 1 |
| 15 | Power systems fault diagnosis us- ing Petri nets显示文摘 | Lo K L Ng H S Trecat J | 1997 | IEE Proceddings-Generation Transmis- sion and Distribution1997，144，3： | 1 |
| 16 | Review of titania nanotubes synthesized via the hydrothermal treatment:Fabrication,modification,and application显示文摘 | Ou H H Lo S L | | 0，，01： | 1 |
| 17 | High performance thermoelectrics from earth-abundant materials: Enhanced figure of merit in PbS by second phase nanostructures 显示文摘 | Zhao L D Lo S H He J Q | 2011 | Journal of the American Chemical Society2011，133，20： | 1 |
| 18 | Cloning and characterizationof Arabidopsis thaliana pyridoxal kinase 显示文摘 | Lum H K Kwok F Lo S C | 2002 | Planta2002，215，： | 1 |
| 19 | Determination of volatile organic compounds in workplace air by multisorbent adsorption/thermal desorption-GC/MS显示文摘 | WU C H FENG C T LO Y S | 2004 | Chemosphere2004，56，1： | 1 |
| 20 | Computational analysis and experimental validation of tumor- associated alternative splicing in human cancer显示文摘 | Wang Z Lo H S Yang H Gere S Hu Y Buetow K H | 2003 | Cancer Res2003，63，： | 1 |
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