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| 1 | Genetics of coronary artery disease and myocardial infarction显示文摘Atherosclerotic coronary artery disease(CAD) comprises a broad spectrum of clinical entities that include asymptomatic subclinical atherosclerosis and its clinical complications, such as angina pectoris, myocardial infarction(MI) and sudden cardiac death. CAD continues to be the leading cause of death in industrialized society. The long-recognized familial clustering of CAD suggests that genetics plays a central role in its development, with the heritability of CAD and MI estimated at approximately 50% to 60%. Understanding the genetic architecture of CAD and MI has proven to be difficult and costly due to the heterogeneity of clinical CAD and the underlying multi-decade complex pathophysiological processes that involve both genetic and environmental interactions. This review describes the clinical heterogeneity of CAD and MI to clarify the disease spectrum in genetic studies, provides a brief overview of the historical understanding and estimation of the heritability of CAD and MI, recounts major gene discoveries of potential causal mutations in familial CAD and MI, summarizes CAD and MIassociated genetic variants identified using candidate gene approaches and genome-wide association studies(GWAS), and summarizes the current status of the construction and validations of genetic risk scores for lifetime risk prediction and guidance for preventive strategies. Potential protective genetic factors against the development of CAD and MI are also discussed. Finally, GWAS have identified multiple genetic factors associated with an increased risk of in-stent restenosis following stent placement for obstructive CAD. This review will also address genetic factors associated with in-stent restenosis, which may ultimately guide clinical decision-making regarding revascularization strategies for patients with CAD and MI. | Xuming Dai Szymon Wiernek James P Evans Marschall S Runge | 2016 | World Journal of Cardiology2016，8，1： | 15 |
| 2 | Voltammetric Determination of the Neonicotinoid Insecticide Thiamethoxam Using a Tricresyl Phosphate-based Carbon Paste Electrode显示文摘 | ZSIGMOND J P VALERIA J G SZYMON K | 2010 | Journal of the Serbian Chemical Society2010，75，5： | 1 |
| 3 | Nonlinear stochastic wave and heat equations显示文摘 | Szymon P Jerzy Z | 2000 | Probab Theory Relat Fields2000，116，： | 1 |
| 4 | 巴塞罗那NATEXO办公室显示文摘西班牙Egue y Seta设计工作室近期完成了巴塞罗那NATEXO办公室的设计。近年来,游乐场式的办公空间风格大行其道,但这种设计未必能贴合每个公司的需求和预算。Natexo公司找到了Egue y Seta设计工作室,希望能将其办公室改造成一个高效且富有青春活力的办公空间,同时也不会因过度的"游乐场"式元素而影响实用性及办公需求。在空间色调的选择上,设计团队采用了大量的互补色彩,形成了对比强烈且醒目的空间效果,并通过运用不同的材质交叠组合. | Danel Pérez Felipe Araujo ángel-Pablo Turio Gaia Trotta Szymon Keller Covadonga Dlaz 范嘉苑 | 2018 | 现代装饰2018，0，5： | 0 |
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