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| 1 | 脑缺血后N-myc下游调控基因2保护血脑屏障完整性显示文摘脑缺血后血脑屏障(BBB)的破坏与外周细胞向脑内浸润、病孔损形成与进展、以及临床病程恶化密切相关。目前BBB完整性的调控机制,尤其是在永久性缺血后的调控机制尚未明确。本研究使用小鼠永久性脑缺血模型进行相关研究,结果显示,星形胶质细胞N-myc下游调控基因2(NDRG2)可能是缺血性脑卒中后BBB通透性的调控分子,该分子与分化和应激相关。免疫组化显示,在永久性大脑中动脉闭塞(MCAO)后,NDRG2在星形胶质细胞中的表达显著增加。敲除NDRG2基因,脑梗死体积增加,免疫细胞在缺血同侧大脑半球积聚增加。MCAO后,NDRG2基因敲除小鼠缺血侧皮质的缺血灶内及灶周血管周围区域内的血清蛋白(包括纤维蛋白原和免疫球蛋白)的外渗增强此之,MCAO后NDRG2基因敲除小鼠体内基质金属蛋白酶(MMPs)的表达也显著增加。在细胞培养中,NDRG2-/-星形胶质细胞中MMP-3的表达和分泌增加,这种增加可被腺病毒介导的NDRG2再表达所逆转。综上所述,脑缺血后,星形胶质细胞内的NDRG2可能通过调节MMP的表达,而在BBB通透性的调节和免疫细胞浸润中起到重要作用。 | Takarada-Iemata M Yoshikawa A Ta HM Okitani N Nishiuchi T Aida Y Kamide T Hattori T Ishii H Tamatani T Le TM Roboon J Kitao Y Matsuyama T Nakada M Hori O 聂昊 | 2018 | 神经损伤与功能重建2018，13，4： | 4 |
| 2 | The effect of mast cell on the induction of Helicobacter pylori infection in Mongolian gerbils显示文摘INTRODUCTION Since 1982,Helicobacter pylori(Hp) has been successfully isolated and cultured,and the fact many diseases such as gastritis,peptic ulcer,gastric carcinoma | S Nakajima T Hattori | 2000 | World Journal of Gastroenterology2000，6，3： | 3 |
| 3 | Laparoscopic radical nephrectomy for renal cell carcinoma: a five - year experience显示文摘 | Ono Y Kinukawa T Hattori R | 1999 | Urology1999，53，2： | 2 |
| 4 | The long -term outcome of laparoscopic radical nephrectomy for small renal cell carcinoma显示文摘 | Ono Y Kinukawa T Hattori R | 2001 | J Urol2001，165，61： | 2 |
| 5 | Optimizing processing varibles in high-temperature brazing with nickel-based filler metals 显示文摘 | Sakamoto A Fujiwara C Hattori T | 1989 | Welding Journal1989，，3： | 2 |
| 6 | GH, GH receptor, GH secretagogue receptor, and ghrelin expression in human T cells, B cells, and neutrophils显示文摘 | Hattori N Saito T Yagyu T | 2001 | Clin Endocrinol Metab2001，86，9： | 2 |
| 7 | Behavioral abnormalities and dopamine reductions in sdy mutant mice with a deletion in Dtnbpl, a susceptibility gene for schizophrenia 显示文摘 | HATTORI S MUROTANI T MATSUZAKI S | 2008 | Biochem Biophys Res Commun2008，373，2： | 1 |
| 8 | Triazine dendrimers by divergent and convergent methods显示文摘 | Takagi K Hattori T Kunisada H | 2000 | Polym Sol Part A: Polym Chem2000，38，： | 1 |
| 9 | Chemokinemediated interaction of hematopoietic progenitors with the bone marrow vascular niche is required for thrombopoiesis显示文摘 | HATTORI K HEISSIG B | 2004 | Nat Med2004，10，1： | 1 |
| 10 | Vapor Phase synthesis of esters over porousion exchanges resin catalyst显示文摘 | Hattori T Uchida H | 1969 | Kogyo Kagaku Zasshi1969，72，9： | 1 |
| 11 | Clinical significance of CD151 gene expression in non-small cell lung cancer 显示文摘 | Tokuhara T Hasegawa H Hattori N | 2001 | Clin Cancer Res2001，7，12： | 1 |
| 12 | Multivariate evaluation of factors affecting recurrence,progression,and survival in patients with superficial bladder cancer(Tokyo 172 strain)therapy:significance of concomitant carcinoma in situ显示文摘 | Takashi M Wakai K Hattori T | 2002 | Int Urol Nephrol2002，33，： | 1 |
| 13 | Diels-Alder reaction using a dendritic copper( Ⅱ )triflate-catalyst :A positive dendritic effect on the chemical yield显示文摘 | Fujita K Muraki T Hattori H | 2006 | Tetrahedron letters2006，47，： | 1 |
| 14 | Four new bioactive bromophenols from the Palauan sponge Phyllospongia dendyi显示文摘 | HATTORI T KONNO A ADACHI K | 2001 | Fish Sci2001，67，5： | 1 |
| 15 | Activation of two distinct anti-proliferative pathways, apoptesis and p38 MAP kinase-dependent cell cycle arrest, by tumor necrosis factor in human melanoma cell line A375显示文摘 | Hattori T Hayashi H Chiha T Onozaki K | 2001 | Eur Cytokine Netw2001，12，2： | 1 |
| 16 | Advances in soil microbial ecology and the biodiversity显示文摘 | Hattori T Mitsui H Haga H 1997 | 1997 | Antonie Van Leeuwenhoek1997，72，： | 1 |
| 17 | Neurotrophin- 3 prevents death of axotomized Clarke's nucleus neurons in adult rat 显示文摘 | SHBAYAMA M HATTORI S HIMES B T | 1998 | J Comp Neurol1998，390，： | 1 |
| 18 | Evaluating posterolateral linearization of the putaminal margin with magnetic resonance imaging to diagnose the Parkinson variant of multiple system atrophy 显示文摘 | Ito S Shirai W Hattori T | 2007 | Mov Disord2007，22，： | 1 |
| 19 | An essential role of the antioxidant gene bcl-2 in myocardial adaptationto ischemia:an insight with antisense bcl-2 therapy 显示文摘 | Hattori R Hemandez T E Zhu L | 2001 | Antioxid Redox Singnal2001，3，4： | 1 |
| 20 | Mutations in the parkingene cause autosomal recessive juvenile parkinsonism 显示文摘 | T ASAKAWA S HATTORI N | 1998 | Nature1998，392，6676： | 1 |
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