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| 1 | Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: Prognosis and outcomes显示文摘AIM: To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical outcomes.METHODS: This study was a retrospective case comparison study using prospectively collected data. The study covered the period from April 2001 to December 2006. The data of 200 patients with histologically confirmed hepatocellular carcinoma were reviewed. Nineteen patients (17 men and 2 women) having received resection in combination with RFA were chosen as subjects of the study (the combination group). Fiftyfour patients (43 men and 11 women) having received resection alone were selected for comparison (the resection group). The two groups matched tumor number and tumor size, and all the patients in the two groups displayed no tumor rupture, major vascular involvement and distant metastasis. Their demographics, preoperative assessment, disease recurrence patterns, overall survival and diseasefree survival were compared.RESULTS: In the combination group, the medianage was 65 years (range, 3477 years), the median tumor number was 3 (range, 29), and the median tumor size was 6 cm (range, 1.214 cm). In the resection group, the median age was 51.5 years (range, 2780 years, P = 0.003), the median tumor number was 3 (range, 29, P = 0.574), and the median tumor size was 6 cm (range, 114 cm, P = 0.782). The two groups were similar in characteristics of tumors and comorbidities, and had comparable results in preoperative liver function tests. All patients had ChildPugh class A status. Bilobar involvement occurred in 14 patients (73.6%) in the combination group and 3 patients (5.5%) in the resection group (P = 0.04). Six patients (32%) in the combination group and 35 patients (65%) in the resection group underwent major hepatectomy. Thirteen patients (68%) in the combination group and 19 patients (35%) in the resection group underwent minor hepatectomy (P = 0.012). The combination group had fewer major resections (32% vs 65%, P = 0.012), less blood loss (400 vs 657 mL, P = 0.007), shorter operation time (270 vs 400 min, P = 0.001), and shorter hospital stay (7 vs 8.5 d, P = 0.042). The two groups displayed no major differences in surgical complications (15.8% vs 31.5%, P = 0.24), disease recurrence (63.2% vs 50%, P = 0.673), hospital mortality (5.3% vs 5.6%, P = 1), and overall survival (53 vs 44.5 mo, P = 0.496).CONCLUSION: Safe and effective for selected patients with multifocal hepatocellular carcinoma, the combination of resection and intraoperative RFA widens the applicability of surgical intervention for the disease. | Tan To Cheung Kelvin K Ng Kenneth S Chok See Ching Chan Ronnie T Poon Chung Mau Lo Sheung Tat Fan | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 2 | 绕正方形排列的顺排的四个圆柱的流动研究显示文摘本文通过采用激光诱导荧关技术(LIF),对按正方形排列、边长间距比为4的顺排的四个圆柱的层流绕流进行了流动可视化研究;同时,在Re=200的情况下,对该流场进行了PIV流场测量,两种实验结果吻合良好,显示的都是只在下游圆柱的后面才有漩涡脱落。可是,采用两维有限体积法离散N-S方程计算该流场与实验结果完全不符合,原因尚不清楚。 | 李景银 K Lam K T Chan R M C So | 2004 | 工程热物理学报2004，25，1： | 14 |
| 3 | 多机组空调系统部分负荷下的节能策略研究显示文摘针对冷水机组大部分时间都是在部分负荷下运行的现状,提出了一种多机组空调系统并联的节能策略.运用模型仿真和试验验证手段研究节能优化运行策略对机组性能改善效果.试验结果表明:当机组由100%负荷降为50%负荷时,机组的冷凝温度由47.2℃下降到42.5℃,蒸发温度由2.2℃上升到3.5℃,COP值提高9.5%.从而表明该节能策略对多机组空调系统在部分负荷下的性能改善具有较大潜力.同时针对试验结果与仿真结果存在的差距,分析了产生的原因并提出了进一步的改进措施. | 梁彩华 张小松 徐国英 Chan K T | 2008 | 应用基础与工程科学学报2008，16，5： | 3 |
| 4 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 5 | An overview of energy sources for electric vehicles显示文摘 | Chau K T Wong Y S Chan C C | 1999 | Energy Conversion and Management1999，40，10： | 2 |
| 6 | Cancer Genome Scanning in Plasma: Detection of Tumor-Associated Copy Number Aberrations, Single-Nucleotide Variants, and Tumoral Heterogeneity by Massively Parallel Sequencing显示文摘 | Chan K C Allen Jiang Peiyong Zheng Yama W L Liao Gary J W Sun Hao Wong John Siu Shing Shun N Chan Wing C Chan Stephen L Chan Anthony T C Lai Paul B S Chiu Rossa W K Lo Y M D | 2013 | Clinical Chemistry2013，，1： | 2 |
| 7 | Performance analysis of 8/6-pole doubly salient permanent magnet motor显示文摘 | Chau K T Cheng Ming Chan C C | 1999 | Electric Machines and Power System1999，27，10： | 1 |
| 8 | Size distributions of maternal and fetal DNA in maternal plasma显示文摘 | Chan K C ZhangJ Hui A B Wong N Lau T K Leung T N | 2004 | Clin Chem2004，50，： | 1 |
| 9 | Integrating Environmental Criteria into the Supplier Selection Process显示文摘 | HUMPHREYS P K WONG Y K CHAN F T S | 2003 | Journal of Materials Processing Technology2003，138，6： | 1 |
| 10 | Modelling Cus- tomer Satisfaction for Product Development Using Genetic Programming显示文摘 | Chan K Y Kwong C K Wong T C | 2011 | Journal of Engineering Design2011，22，1： | 1 |
| 11 | On the training of radial basis function classifiers 显示文摘 | Musavi M T Ahmed W Chan K H | 1992 | Neural Networks1992，，5： | 1 |
| 12 | Cytotoxic Acylated Triterpene Saponins from the husks of Xanthoceras sorbifolia显示文摘 | Chan P K Zhao M Che C T | 2008 | J Nat Prod2008，71，： | 1 |
| 13 | Six month radiologieal and physiological outcomes in severe acute respiratory syndrome(SARS) survivors 显示文摘 | Ng C K Chan J W Kwan T L | 2004 | Thorax2004，59，： | 1 |
| 14 | Design and analysis of a new doubly salient permanent magnet motor显示文摘 | Cheng M Chau K T Chan C C | 2001 | IEEE Trans on Magnetics2001，37，4： | 1 |
| 15 | Rational harmonic active and passive modelocking in a figure-of-eight fiber laser显示文摘 | LI S P LOU C Y CHAN K T | 1998 | Electronics Letters1998，34，4： | 1 |
| 16 | Effects of diabetes and recurrent hypoglycemia on the regulation of the sympathoadrenal system and hypothalamo-pituitary-adrenal axis显示文摘 | Inouye K E Chan O Yue J T | 2005 | Am J Physiol Endocrinol Metab2005，288，： | 1 |
| 17 | The competitiveness of small and medium enterprises:a conceptualization with foeus on entrepreneurial competencies 显示文摘 | MAN T W Y LAU T CHAN K F | 2002 | Journal of Business Venturing2002，17，： | 1 |
| 18 | An Imaging Technique Us- ing Confocal Circular Synthetic Aperture Radar 显示文摘 | Ishimaru A Chan T K Kuga Y | 1998 | IEEE Transactions on Geoscience and Remote Sensing1998，36，5： | 1 |
| 19 | Acute kidney injury in the paediatric intensive care unit:identification by modified RI- FLE criteria显示文摘 | HUI W F CHAN W K MIU T Y | 2013 | Hong Kong Med J2013，19，1： | 1 |
| 20 | The influence of greening the suppliers and green innovation on environmental performance and competitive advantage in Taiwan 显示文摘 | Chiou T Chan H K Lettice F | 2011 | Transportation Research E2011，47，6： | 1 |
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