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| 1 | 全氟辛烷磺酰基化合物(PFOS)的污染现状与研究趋势显示文摘全氟辛烷磺酰基化合物(PFOS,perfluorooctane sulfonate)所造成的污染已经逐渐成为全球性环境问题,发达国家非常重视PFOS等全氟化合物的研究,已经成为持久性有机污染物研究的又一个热点。本文对目前PFOS研究的现状、进展,以及存在的问题做了简要回顾,并且对今后研究重点做了预测,希望对PFOS研究者提供参考。 | 郭睿 蔡亚岐 江桂斌 K S Paul Lam | 2006 | 化学进展2006，18，6： | 92 |
| 2 | Estimating liver weight of adults by body weight and gender显示文摘瞄准:为了为估计接枝的足够估计标准肝重量,为癌症在主要肝切除术在实时施主肝移植和残余肝缩放。方法:在这研究,体重和身高的人体测量的数据在 159 个实时的肝施主为与肝重量的关联被测试包括中间的肝的静脉经历了施主权利肝切除术。肝重量从在背表格获得的正确脑叶接枝重量被计算,在计算断层摄影术上由正确脑叶的比例划分了。结果:这些题目,所有汉语,有 35.8+/-10.5 年,和女性的吝啬的年龄到 118:41 的男比率。正确脑叶的吝啬的体积是 710.14+/-131.46 mL 并且在计算断层摄影术上占据了整个肝的 64.55%+/-4.47% 。正确脑叶称了 598.90+/-117.39 g,估计的肝重量是 927.54+/-168.78 g。当体重和身高受到多重逐步的线性回归分析时,身高被发现不足道。一样的体重的女性有稍微更低的肝重量。一个公式基于体重和性被导出:估计的标准肝重量(g)= 218 + BW (kg ) x 12.3 + 性 x 51 (R2 = 0.48 )( 女 = 0,男 = 1 ) 。基于这 159 个题目,的人体测量的数据肝重量用在白种人,日语,朝鲜语,和汉语上从研究导出的以前出版的公式被计算。所有公式与这个公式相比过高估计肝重量。日本公式为成年人过高估计估计的标准肝重量(ESLW ) 不到 60 kg。结论:对中国男性和女性适用的一个公式是可得到的。为单个赛跑的一个公式显得必要。 | See Ching Chan Chi Leung Liu Chung Mau Lo Banny K Lam Evelyn W Lee Yik Wong Sheung Tat Fan | 2006 | World Journal of Gastroenterology2006，12，14： | 22 |
| 3 | Intracellular signaling mechanisms regulating the activation of human eosinophils by the novel Th2 cytokine IL-33:implications for allergic inflammation显示文摘The novel interleukin(IL)-1 family cytokine IL-33 has been shown to activate T helper 2(Th2)lymphocytes,mast cells and basophils to produce an array of proinflammatory cytokines,as well as to mediate blood eosinophilia,IgE secretion and hypertrophy of airway epithelium in mice.In the present study,we characterized the activation of human eosinophils by IL-33,and investigated the underlying intracellular signaling mechanisms.IL-33 markedly enhanced eosinophil survival and upregulated cell surface expression of the adhesion molecule intercellular adhesion molecule(ICAM)-1 on eosinophils,but it suppressed that of ICAM-3 and L-selectin.In addition,IL-33 mediates significant release of the proinflammatory cytokine IL-6 and the chemokines CXCL8 and CCL2.We found that IL33-mediated enhancement of survival,induction of adhesion molecules,and release of cytokines and chemokines were differentially regulated by activation of the nuclear factor(NF)-KB,p38 mitogen-activated protein kinase(MAPK)and extracellular signal-regulated kinase(ERK)pathways.Furthermore,we compared the above IL-33 activities with two structurally and functionally related cytokines,IL-1 B and IL-18.IL-1β,but not IL-18,markedly upregulated cell surface expression of ICAM-1.IL-1βand IL-18 also significantly enhanced eosinophil survival,and induced the release of IL-6 and chemokines CXCL8 and CCL2 via the activation of the NF-κB,p38 MAPK and ERK pathways.Synergistic efects on the release of IL-6 were also observed in combined treatment withIL-1B,IL-18 and IL-33.Taken together,our findings provide insight into IL-33-mediated activation of eosinophils via differential intracellular signaling cascades in the immunopathogenesis of allergic inflammation. | Joyce YS Chow Chun K Wong Phyllis FY Cheung Christopher WK Lam | 2010 | Cellular & Molecular Immunology2010，7，1： | 22 |
| 4 | 香港地区一次光化学污染过程的特征分析显示文摘对2000年3月28-31日发生在香港地区的一次光化学污染过程进行了分析。在这次过程中,O3、NO2、CO、RSP、SO2的最大浓度分别达到175.2μg/m3,333.5μg/m3,5405μg/m3,349.3μg/m3,132.8μg/m3,污染持续时间三天,影响范围覆盖香港全境。利用同步的气象资料和大气污染监测数据,进行了浓度变化分析、气象条件分析、局地光化学机制分析和输送机制分析。结果揭示了这次污染过程的基本特征,并指出造成这次大气污染的可能原因:晴天高温、低湿的气象条件和局地污染物的排放对此次光化学烟雾的形成有重要作用;外地污染物的输送对污染形成也有一定贡献。香港地区所处的地理位置、城市布局和交通状况有利于光化学污染的形成。 | 谢旻 王体健 高丽洁 LAM K S | 2004 | 热带气象学报2004，20，4： | 17 |
| 5 | 绕正方形排列的顺排的四个圆柱的流动研究显示文摘本文通过采用激光诱导荧关技术(LIF),对按正方形排列、边长间距比为4的顺排的四个圆柱的层流绕流进行了流动可视化研究;同时,在Re=200的情况下,对该流场进行了PIV流场测量,两种实验结果吻合良好,显示的都是只在下游圆柱的后面才有漩涡脱落。可是,采用两维有限体积法离散N-S方程计算该流场与实验结果完全不符合,原因尚不清楚。 | 李景银 K Lam K T Chan R M C So | 2004 | 工程热物理学报2004，25，1： | 14 |
| 6 | 广州队列研究生物库中条形码技术应用与评价显示文摘目的建立大规模人群的分子流行病学队列研究生物库,确保快速、准确地识别每一份生物样本,并保持其活性,以便长时间跟踪研究。方法采用条形码识别技术对血液样品的采集、处理及存储、查询过程进行全程管理。结果创建成功以条形码自动识别技术为核心的新型运作管理模式,建立起10 000人份的生物样品库。大型生物样本库实施条形码管理系统可缩短每份样品的处理时间,提高工作效率1.5倍。结论条形码技术的应用可有效地避免样品间的相互混淆,使实验室每一项工作准确、可靠、高效,实现医学研究工作全面信息化,提高基因队列研究的质量。 | 朱彤 李成毅 江朝强 TH Lam K K Cheng | 2006 | 中国公共卫生2006，22，9： | 6 |
| 7 | Activation of human fibroblast-like synoviocytes by uric acid crystals in rheumatoid arthritis显示文摘Hyperuricemia-mediated uric acid crystal formation may cause joint inflammation and provoke the destruction of joints through the activation of inflammasome-mediated innate immune responses.However,the immunopathological effects and underlying intracellular regulatory mechanisms of uric acid crystal-mediated activation of fibroblast-like synoviocytes(FLS)in rheumatoid arthritis(RA)have not been elucidated.Therefore,we investigated the in vitro effects of monosodium urate crystals,alone or in combination with the inflammatory cytokines tumor-necrosis factor(TNF)-a or interleukin(IL)-1b,on the activation of human FLS from RA patients and normal control subjects and the underlying intracellular signaling mechanisms of treatment with these crystals.Monosodium urate crystals were able to significantly increase the release of the inflammatory cytokine IL-6,the chemokine CXCL8 and the matrix metalloproteinase(MMP)-1 from both normal and RA-FLS(all P,0.05).Moreover,the additive or synergistic effect on the release of IL-6,CXCL8 and MMP-1 from both normal and RA-FLS was observed following the combined treatment with monosodium urate crystals and TNF-a or IL-1b.Further experiments showed that the release of the measured inflammatory cytokine,chemokine and MMP-1 stimulated by monosodium urate crystals were differentially regulated by the intracellular activation of extracellular signal-regulated kinase and c-Jun N-terminal kinase pathways but not the p38 mitogen-activated protein kinase pathway.Our results therefore provide a new insight into the uric acid crystal-activated immunopathological mechanisms mediated by distinct intracellular signal transduction pathways leading to joint inflammation in RA. | Da P Chen Chun K Wong Lai S Tam Edmund K Li Christopher WK Lam | 2011 | Cellular & Molecular Immunology2011，8，6： | 5 |
| 8 | 利钠肽受体2的缺乏促进小鼠二叶主动脉瓣、主动脉瓣疾病、左心室功能不全以及升主动脉扩张显示文摘主动脉瓣疾病是无有效药物治疗的细胞介导的病变过程。C型利钠肽(C-type natriuretic peptide,CNP)抑制瓣膜间质细胞(valve interstitial cells,VIC)的肌纤维形成和成骨过程,并且在出现主动脉瓣狭窄时水平下调。然而,CNP信号是否调节体内主动脉瓣的健康状态尚不清楚。该研究旨在确定小鼠CNP信号通路的缺失是否导致主动脉瓣疾病加速发展。 | 刘青 叶鹏 Blaser MC Wei K Adams RL Zhou YQ Caruso LL Mirzaei Z Lam A Tam RK Zhang H Heximer SP Henkelman M Simmons CA | 2018 | 中华高血压杂志2018，26，1： | 3 |
| 9 | 工人脱离职业性噪声接触后的心电图分析显示文摘目的探讨工人脱离职业性噪声接触后的心电图变化。方法在进行《广州生物库队列研究》时,第一阶段收集10413名年龄在≥50岁居民的一般资料、体格检查和实验室检查结果。受检者70%为女性,50%以上年龄在60~69岁;受检者中有2120名(21.0%)曾经接触职业性噪声,但均已脱离接触且为退休或离岗者;用上海惠普有限公司制造的MAC-CS多导联心电图机进行12导联的心电图检查;噪声职业接触史通过问卷采集,心电图由2名中级以上具有诊断资格的医师进行独立诊断。结果(1)心电图异常检出率女性为82.4%,明显高于男性的79.1%;不论男性或女性,心电图异常检出率随年龄增加而上升(P=0.000),女性随文化程度增高而明显下降(P=0.000),但无论男女,脱离职业性噪声接触后,其心电图异常检出率与从未职业性噪声接触者比较,差异无统计学意义(P>0.05);(2)比较曾经有职业性噪声接触与非接触者心电图异常的分类,在校正年龄因素和文化程度后,心律失常、心电轴偏移、房或室肥厚、ST-T改变、心肌劳损、冠状动脉综合征等比较,差异无统计学意义(P>0.05)。结论脱离职业性噪声接触后的工人心电图异常检出率未见明显高于非职业性噪音接触者。 | 林洁明 江朝强 张维森 侯丽君 Cheng K K Lam T H | 2007 | 中华劳动卫生职业病杂志2007，25，10： | 3 |
| 10 | Amine-catalyzed polycyclotrimerization of arylene bipropiolate:A metal-free and regioselective route to hyperbranched polymer显示文摘This paper presents a new synthetic route to hyperbranched polymer. An arylene bipropiolate monomer,dimethylmethylenebis(1,4-phenylene) bipropiolate,was prepared by a one-step esterification reaction of bisphenol A with propiolic acid. Polycyclotrimrtization of the monomer was effected by reflux in dimethylformamide(DMF),producing a soluble hyperbranched poly(aroxycarbonylphenylene) in a good yield. The polymer was perfectly branched with a degree of branching of 100%. | JIM Cathy K W LAM Jacky W Y HAEUSSLER Matthias | 2008 | Science China Chemistry2008，51，8： | 3 |
| 11 | Novel role of STAT3 in microglia-dependent neuroinflammation after experimental subarachnoid haemorrhage显示文摘Background and purpose Signal transducer and activator of transcription 3(STAT3)may contribute to the proinflammation in the central nervous system diseases by modulating the microglial responses.Thus,this study was intended to investigate the effect of STAT3 on microglia-dependent neuroinflammation and functional outcome after experimental subarachnoid haemorrhage(SAH).Methods The SAH model was established by endovascular perforation in the mouse.Real-time PCR(RtPCR)and western blot were used to examine the dynamic STAT3 signalling pathway responses after SAH.To clarify the role of the STAT3 signalling pathway in the microglia-dependent neuroinflammation after SAH,the microglia-specific STAT3 knockout(KO)mice were generated by the Cre-LoxP system.The neurological functions were assessed by Catwalk and Morris water maze tests.Neuronal loss after SAH was determined by immunohistochemistry staining.Microglial polarisation status after STAT3 KO was then examined by RtPCR and immunofluorescence.Results The STAT3 and Janus kinase-signal transducer 2 activated immediately with the upregulation and phosphorylation after SAH.Downstream factors and related mediators altered dynamically and accordingly.Microglial STAT3 deletion ameliorated the neurological impairment and alleviated the early neuronal loss after SAH.To investigate the underlying mechanism,we examined the microglial reaction after STAT3 KO.STAT3 deletion reversed the increase of microglia after SAH.Loss of STAT3 triggered the early morphological changes of microglia and primed microglia from M1 to M2 polarisation.Functionally,microglial STAT3 deletion suppressed the SAH-induced proinflammation and promoted the anti-inflammation in the early phase.Conclusions STAT3 is closely related to the microglial polarisation transition and modulation of microglia-dependent neuroinflammation.Microglial STAT3 deletion improved neurological function and neuronal survival probably through promoting M2 polarisation and anti-inflammatory responses after SAH.STAT3 may serve as a promising therapeutic target to alleviate early brain injury after SAH. | Zhiyuan Vera Zheng Junfan Chen Hao Lyu Sin Yu Erica Lam Gang Lu Wai Yee Chan George K C Wong | 2022 | Stroke & Vascular Neurology2022，7，1： | 3 |
| 12 | Stability analysis and observer design for neutral delay systems 显示文摘 | Wang Z Lam J Burnham K J | 2001 | IEEE Trans on Automatic Control2001，47，8： | 2 |
| 13 | 基于GATS算法的城市土地使用规划问题研究显示文摘土地使用规划就是确定和选择可能的发展区域以满足使用土地的要求 (包括新区域的形成及提供公共服务设施 ) ,最优土地发展规划就是从许多可能的发展区域和人口分配方案中选择最好的方案 ,这一问题能归结为一个单目标 0 -1规划问题。本文根据遗传算法和禁忌搜索算法自身的优势与不足 ,提出一种将二者混合使用求解土地使用规划的算法 ,以使总的费用最少 ,同时针对此模型中约束函数的特点 ,提出一种处理约束的新方法 ,并用实际问题进行了数值实验。 | 孙艳丰 William H K Lam | 2002 | 公路交通科技2002，19，4： | 2 |
| 14 | Soluble E-cadherin is a valid prognostic marker in gastric carcinoma显示文摘 | Chan A O Lam S K Chu K M | 2001 | Gut2001，48，6： | 2 |
| 15 | Stability analysis and observer design for neutral delay systems 显示文摘 | Wang Zidong Lam J Burnham K J | 2002 | IEEE Tran Automat Contr2002，47，3： | 2 |
| 16 | Locating and extracting the eye in human face images显示文摘 | LAM K YAN Hong | 1996 | Pattern Recognition1996，29，5： | 2 |
| 17 | 用总氧自由基清除能力测定生物样品及抗氧化剂的总抗氧化能力显示文摘目的建立一项用于反映抗氧化剂或生物组织抗氧化能力的指标——总氧自由基清除能力(TOSC)。方法用气相色谱法测定几种抗氧化剂及小鼠肝、心、肾的TOSC。结果TOSC与抗氧化剂浓度有很好的剂量-效应关系,维生素C的TOSC高于谷胱甘肽的TOSC,小鼠心TOSC在几种组织中最高,不同个体小鼠间TOSC差异不大。结论TOSC水平与抗氧化剂和生物样品的浓度相关,且在小鼠间个体差异不大,可作为一项有意义的生物标志物用于化学品评价。 | 卢小英 叶怀庄 蔡德雷 徐立红 Paul K S Lam | 2003 | 环境与健康杂志2003，20，5： | 2 |
| 18 | Induction of lymphocyte agglutination and lysis by Newcastle disease virus 显示文摘 | Lam K M Hao Q | 1987 | Vet Micro1987，35，： | 1 |
| 19 | Hospital lift system simulator: A performance Evaluator Predictor显示文摘 | Sydney C K Chu Lin C K Y Lam S S | 2003 | European Journal of Operational Research2003，146，1： | 1 |
| 20 | A Traffic Flow Simulator for Network Reliabihty Assessment显示文摘 | LAM W H K XU G | 1999 | Journal of Advanced Transportation1999，33，2： | 1 |
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