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| 1 | Lansoprazole prevents experimental gastric injury induced by non-steroidal anti-inflammatory drugs through a reduction of mucosal oxidative damage显示文摘AIM: This study investigated the mechanisms of protection afforded by the proton pump inhibitor lansoprazole against gastric injury induced by different non-steroidal antiinflammatory drugs (NSAIDs) in rats.METHODS: Male Sprague-Dawley rats were orally treated with indomethacin (100 μmol/kg), diclofenac (60 μmol/kg),piroxicam (150 μmol/kg) or ketoprofen (150 μmol/kg).Thirty minutes before NSAIDs, animals were orally treated with lansoprazole 18 or 90 μmol/kg. Four hours after the end of treatments, the following parameters were assessed: gastric mucosal PGE2, malondialdehyde (MDA), myeloperoxidase (MPO) or non-proteic sulfhydryl compounds (GSH) levels; reverse transcription-polymerase chain reaction (RT-PCR) of mucosal COX-2 mRNA; gastric acid secretion in pylorus-ligated animals; in vitro effects of lansoprazole (1-300 μmol/L) on the oxidation of low density lipoproteins (LDLs) induced by copper sulphate.RESULTS: All NSAIDs elicited mucosal necrotic lesions which were associated with neutrophil infiltration and reduction of PGE2 levels. Increments of MPO and MDA contents, as well as a decrease in GSH levels were detected in the gastric mucosa of indomethacin- or piroxicam-treated animals. Indomethacin enhanced mucosal cyclooxygenase-2 expression, while not affecting cyclooxygenase-1. At the oral dose of 18 μmol/kg lansoprazole partly counteracted diclofenac-induced mucosal damage, whereas at 90 μmol/kg it markedly prevented injuries evoked by all test NSAIDs. Lansoprazole at 90 μmol/kg reversed also the effects of NSAIDs on MPO, MDA and GSH mucosal contents, without interfering with the decrease in PGE2 levels or indomethacin-induced cyclooxygenase-2 expression. However, both lansoprazole doses markedly inhibited acid secretion in pylorus-ligated rats. Lansoprazole concentration-dependently reduced the oxidation of LDLs in vitro.CONCLUSION: These results suggest that, besides the inhibition of acid secretion, lansoprazole protection against NSAID-induced gastric damage depends on a reduction in mucosal oxidative injury, which is also responsible for an increment of sulfhydryl radical bioavailability. It is also suggested that lansoprazole does not influence the downregulation of gastric prostaglandin production associated with NSAID treatment. | Corrado Blandizzi Matteo Fornai Rocchina Colucci Gianfranco Natale Valter Lubrano Cristina Vassalle Luca Antonioli Gloria Lazzeri Mario Del Tacca | 2005 | World Journal of Gastroenterology2005，11，26： | 9 |
| 2 | Role of coxibs in the strategies for gastrointestinal protection in patients requiring chronic non-steroidal anti-inflammatory therapy显示文摘 | Corrado Blandizzi Marco Tuccori Rocchina Colucci Matteo Fornai Luca Antonioli Narcisa Ghisu Mario Del Tacca | 2008 | Pharmacological Research2008，，2： | 1 |
| 3 | Emerging role of cyclooxygenase isoforms in the control of gastrointestinal neuromuscular functions显示文摘 | Matteo Fornai Luca Antonioli Rocchina Colucci Nunzia Bernardini Narcisa Ghisu Marco Tuccori Roberto De Giorgio Mario Del Tacca Corrado Blandizzi | 2009 | Pharmacology and Therapeutics2009，，1： | 1 |
| 4 | Role of coxibs in the strategies for gastrointestinal protection in patients requiring chronic non-steroidal anti-inflammatory therapy显示文摘 | Corrado Blandizzi Marco Tuccori Rocchina Colucci Matteo Fornai Luca Antonioli Narcisa Ghisu Mario Del Tacca | 2008 | Pharmacological Research2008，，2： | 1 |
| 5 | Cyclooxygenase-2 Induction after Oral Surgery Does Not Entirely Account for Analgesia after Selective Blockade of Cyclooxygenase 2 in the Preoperative Period显示文摘 | Matteo Fornai Rocchina Colucci Filippo Graziani Silvia Cei Luca Antonioli Matteo Tonelli Cristina Vassalle Corrado Blandizzi Mario Gabriele Mario Del Tacca | 2006 | Anesthesiology2006，，1： | 1 |
| 6 | KAGRA引力波探测器中频率相关压缩态实验进展显示文摘随着技术的发展,下一代引力波探测器的激光功率将得到进一步提高。大光斑半径的应用也将使探测器的热噪声进一步降低,因此,量子噪声将成为在全频段限制引力波探测器灵敏度的首要因素。作为目前最有保障的一种降低量子噪声的技术,频率相关压缩态很可能将被应用于下一代所有引力波探测器中^([1])。频率相关压缩态可以通过将频率不相关压缩态与滤波腔相结合而产生。基于滤波腔具有的频率响应特性,这一技术的应用可以使低频波段的辐射压噪声有效降低,同时实现高频波段散粒噪声的降低,从而实现全探测频段灵敏度的提升。基于日本KAGRA引力波探测器的设计,我们预计将9dB压缩度的压缩态与周损失为8×10^(-5)的300m滤波腔相结合,可以使探测器灵敏度在全探测频段提高1倍。此实验于2015年开始,目前滤波腔的安装调试已经基本完成,得到的结果基本与实验前的模拟相符合。与频率不相关压缩态光学实验台的安装过程也已经过半,通过温度和控制回路的调制,二次谐波腔的转化率已经超过50%。 | 郭越凡 CAPOCASA Eleonora EISENMANN Marc FLAMINIO Raffaele LEONARDI Matteo TACCA Matteo 肇宇航 李木子 吕振伟 | 2019 | 天文学进展2019，37，1： | 0 |
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