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| 1 | Stratification of outcomes for mucinous appendiceal adenocarcinoma with peritoneal metastasis by histological grade显示文摘AIM To investigate the importance of a three-tiered histologic grade on outcomes for patients with mucinous appendiceal adenocarcinoma(MAA).METHODS Two hundred and sixty-five patients with MAA undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy were identified from a prospective database from 2004 through 2014. All pathology was reviewed by our gastrointestinal subspecialty pathologists and histological grade was classified as well-differentiated, moderately differentiated, and poorly differentiated. Survival analysis was performed using Cox proportional hazards regression.RESULTS There were 201(75.8%) well-, 45(16.9%) moderatelyand 19(7.2%) poorly-differentiated tumors. Histological grade significantly stratified the 5-year overall survival(OS), 94%, 71% and 30% respectively(P < 0.001) as well as the 5-year disease-free survival(DFS) 66%, 21% and 0%, respectively(P < 0.001). Independent predictors of DFS included tumor grade(HR = 1.78, 95%CI: 1.21-2.63, P = 0.008), lymph node involvement(HR = 0.33, 95%CI: 0.11-0.98, P < 0.02), previous surgical score(HR = 1.31, 95%CI: 1.1-1.65, P = 0.03) and peritoneal carcinomatosis index(PCI)(HR = 1.05, 95%CI: 1.02-1.08, P = 0.002). Independent predictors of OS include tumor grade(HR = 2.79, 95%CI: 1.26-6.21, P = 0.01), PCI(HR = 1.10, 95%CI: 1.03-1.16, P = 0.002), and complete cytoreduction(HR = 0.32, 95%CI: 0.11-0.92, P = 0.03). Tumor grade and PCI were the only independent predictors of both DFS and OS. Furthermore, histological grade and lymphovascular invasion stratified the risk of lymph node metastasis into a low(6%) and high(40%) risk groups. CONCLUSION Our data demonstrates that moderately differentiated MAA have a clinical behavior and outcome that is distinct from well-and poorly-differentiated MAA. The threetier grade classification provides improved prognostic stratification and should be incorporated into patient selection and treatment algorithms. | Travis Edward Grotz Richard E Royal Paul F Mansfield Michael James Overman Gary N Mann Kristen Ashlee Robinson Karen A Beaty Safiea Rafeeq Auerlio Matamoros Michelle W Taggart Keith Francis Fournier | 2017 | World Journal of Gastrointestinal Oncology2017，9，9： | 2 |
| 2 | Simultaneous endocardial and epicardial monophasic action potential recordings during brief periods of coronary artery ligation in the dog: influence of adrenaline, beta blockade and alpha blockade显示文摘 | TAGGART P SUTTON P M SPEAR D W | 1988 | Cardiovase Res1988，22，： | 1 |
| 3 | Electrocardiogram, plasma catecholamines and lipis and their modification by oxyprendol when speaking before audience显示文摘 | Taggart P Carruthers M Somerville W | 1973 | Lancet1973，2，： | 1 |
| 4 | Electrocardiogram, plasma catecholamines and lipids, and their modification by oxyprenolol when speaking before an audience显示文摘 | Taggart P Carruthers M Scmerville W | 1973 | Lancet1973，2，7825： | 1 |
| 5 | Human information processing in information and decision support systems 显示文摘 | Robey D Taggart W | 1982 | MIS Quarterly1982，6，2： | 1 |
| 6 | Evaluation of an In Vitro Assay for Gamma Interferon Production in Response to Mycobacterium tuberculosis Infections显示文摘 | Taggart E W Hill H R Ruegner R G | 2004 | Clinical and diagnostic laboratory immunology2004，11，6： | 1 |
| 7 | Re- vision anterior cruciate ligament reconstruction: A midterm patient assessment 显示文摘 | TAGGART W F KUMAR A BICKERSTAFF D R | 2004 | The Knee2004，11，1： | 1 |
| 8 | Oil-water separation using hydrocyclones: an experimental search for optimum dimensions 显示文摘 | Young G A B Waklay W D Taggart D L | 1994 | Journal of Petroleum Science and Engineering1994，11，： | 1 |
| 9 | Are You Hiding from Your Boss? The Development of A Taxonomy and Instrument to Assess the Feedback Behaviors of Good and Bad Performers显示文摘 | MOSS S E VALENZI E R TAGGART W | 2003 | Journal of Management2003，29，4： | 1 |
| 10 | Use of heat labile UNG in an RT-PCR assay for enterovims detection 显示文摘 | Taggart E W Carroll K C Byington C L | 2002 | J Virol Methods2002，105，1： | 1 |
| 11 | Oil-water Separation Using Hvdrocyclones:an Experimen-tal Search for Optimum Dimensions显示文摘 | YONG G A B WAKLAY W D TAGGART D L et a1 | | 0，，11： | 1 |
| 12 | Sex hormone levels in youn- ger male stroke survivors显示文摘 | Taggart H Sheridan B Stout R W | 1980 | Atherosclerosis1980，35，1： | 1 |
| 13 | Long-term(48-week) safety of ezetimibe 10 mg/day coadministered with simvastatin compared to simvastatin alone in patients with primary hypercholesterolemia显示文摘 | BAYS H SAPRE A TAGGART W | 2008 | Curr Med Res Opin2008，24，10： | 1 |
| 14 | Evaluation of an in vitro assay for gamma interferon production in response to mycobacterium tuberculisis infections显示文摘 | Taggart E W Hill H R Ruegner R G | 2004 | Clinical and Diagnostic Laboratory Immunology2004，11，6： | 1 |
| 15 | Intergovernmental Relations and Native American Gaming: A Case Study on the Emergence of a New Intergovemmental Relations Participant 显示文摘 | MAYS G L TAGGART W A | 2005 | The American Review of Public Administration2005，35，： | 1 |
| 16 | Effects of abrupt changes in ventricular loading on repolarization induced by transient aortic occlusion in humans显示文摘 | Taggart P Sutton P Lab M Runnalls M O′Brien W Treasure T | 1992 | Am J Physiol1992，263，32： | 1 |
| 17 | Minds and managers:on the dual nature of human information processing and management显示文摘 | Taggart W Robey D | 1981 | Academy of Management Review1981，6，： | 1 |
| 18 | Longterm (48-week) safety of ezetimibe 10 mg/ day coadministered with simvastatin compared to simvastatin alone in patients with primary hypercholesterolemia显示文摘 | BAYS H SA PRE A TAGGART W | 2008 | Curr Med Res Opin2008，24，： | 1 |
| 19 | Oil-water separation using hydrocyclones:An experimental search for optimum dimensions 显示文摘 | Yong G A B Wakley W D Taggart D L et at | 1994 | J of Petroleum Science and Engineer1994，，11： | 1 |
| 20 | Oil-water separation using hydrocyclones: an experimental search for optimum dimensions显示文摘 | YOUNG G A WAKLEY W D TAGGART D L | 1994 | Journal of Petroleum Science and Engineering1994，，11： | 1 |
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