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| 1 | Profiling cellular bioenergetics, glutathione levels, and caspase activities in stomach biopsies of patients with upper gastrointestinal symptoms显示文摘AIM: To measure biochemical parameters in stomach biopsies and test their suitability as diagnostic biomarkers for gastritis and precancerous lesions.METHODS: Biopsies were obtained from the stomachs of two groups of patients(n = 40) undergoing fiberoptic endoscopy due to upper gastrointestinal symptoms. In the first group(n = 17), only the corpus region was examined. Biopsies were processed for microscopic examination and measurement of mitochondrial O2 consumption(cellular respiration), cellular adenosine triphosphate(ATP), glutathione(GSH), and caspase activity. In the second group of patients(n = 23), both corpus and antral regions were studied. Some biopsies were processed for microscopic examination, while the others were used for measurements of cellular respiration and GSH level.RESULTS: Microscopic examinations of gastric corpus biopsies from 17 patients revealed normal mucosae in 8 patients, superficial gastritis in 7 patients, and chronic atrophic gastritis in 1 patient. In patients with normal histology, the rate(mean ± SD) of cellular respiration was 0.17 ± 0.02 μmol/L O2 min-1 mg-1, ATP content was 487 ± 493 pmol/mg, and GSH was 469 ± 98 pmol/mg. Caspase activity was detected in 3 out of 8 specimens. The values of ATP and caspase activity were highly variable. The presence of superficial gastritis had insignificant effects on the measured biomarkers. In the patient with atrophic gastritis, cellular respiration was high andATP was relatively low, suggesting uncoupling oxidative phosphorylation. In the second cohort of patients, the examined biopsies showed either normal or superficial gastritis. The rate of cellular respiration(O2. μmol/L min-1 mg-1) was slightly higher in the corpus than the antrum(0.18 ± 0.05 vs 0.15 ± 0.04, P = 0.019). The value of GSH was about the same in both tissues(310 ± 135 vs 322 ± 155, P = 0.692).CONCLUSION: The corpus mucosa was metabolically more active than the antrum tissue. The data in this study will help in understanding the pathophysiology of gastric mucosa. | Ali S Alfazari Bayan Al-Dabbagh Wafa Al-Dhaheri Mazen S Taha Ahmad A Chebli Eva M Fontagnier Zaher Koutoubi Jose Kochiyi Sherif M Karam Abdul-Kader Souid | 2015 | World Journal of Gastroenterology2015，21，2： | 2 |
| 2 | First United Arab Emirates consensus on diagnosis and management of inflammatory bowel diseases:A 2020 Delphi consensus显示文摘Ulcerative colitis and Crohn’s disease are the main entities of inflammatory bowel disease characterized by chronic remittent inflammation of the gastrointestinal tract.The incidence and prevalence are on the rise worldwide,and the heterogeneity between patients and within individuals over time is striking.The progressive advance in our understanding of the etiopathogenesis coupled with an unprecedented increase in therapeutic options have changed the management towards evidence-based interventions by clinicians with patients.This guideline was stimulated and supported by the Emirates Gastroenterology and Hepatology Society following a systematic review and a Delphi consensus process that provided evidence-and expert opinion-based recommendations.Comprehensive up-to-date guidance is provided regarding diagnosis,evaluation of disease severity,appropriate and timely use of different investigations,choice of appropriate therapy for induction and remission phase according to disease severity,and management of main complications. | Maryam Alkhatry Ahmad Al-Rifai Vito Annese Filippos Georgopoulos Ahmad N Jazzar Ahmed M Khassouan Zaher Koutoubi Rahul Nathwani Mazen S Taha Jimmy K Limdi | 2020 | World Journal of Gastroenterology2020，26，43： | 2 |
| 3 | Mesoscale meteorological and air quality impacts of increased urban albedo and vegetation 显示文摘 | TAHA H DOUGLAS S HANEY J | 1997 | EnergBuild1997，25，： | 1 |
| 4 | Upper gastrointestinal mucosal abnormalities and blood loss complicating low-dose aspirin and antithrombotic therapy显示文摘 | TAHA A S ANGERSON W J KNILL-JONES R P | 2006 | Aliment Pharmacol Ther2006，23，4： | 1 |
| 5 | Electrochemical behavior of Sn - Ni nanostructured compound in alkaline media and the effect of halide ions 显示文摘 | Refaey S A M Taha F A Hasanin T H | 2004 | Applied Surface Science2004，227，： | 1 |
| 6 | Influence of the operating conditions on the elimination of zinc ions by nanofiltration显示文摘 | Frarbs N B Taha S Dorange G | 2005 | Desalination2005，185，13： | 1 |
| 7 | Corrosionand Inhibition of Stainless Steel Pitting Corrosion in Alka- line Medium and the Effect of C1- and Br- Anions 显示文摘 | REFAEY S A M TAHA F EL-MALAK A M A | 2005 | Ap- plied Surface Science2005，242，12： | 1 |
| 8 | Evaluation of open-graded friction course mixtures containing cellulose fibers and styrene butadiene rubber polymer显示文摘 | HASSAN H F AI-ORAIM S TAHA R | 2005 | Journal of Materials in Civil Engineering2005，17，4： | 1 |
| 9 | Passivation and pitting corrosion of nanostructured Sn-Ni alloy in NaCl solutions显示文摘 | Refaey S A M Taha F A Hasanin T H | 2006 | Electrochimica Acta2006，51，： | 1 |
| 10 | Incidence of vascular malformations in spontaneous intra-cerebral haemorrhage in children显示文摘 | Papadias A Taha A Sgouros S | 2007 | Childs Nerv Syst2007，23，8： | 1 |
| 11 | Evaluation of 3D numerisation with structured light projection in breast surgery显示文摘 | SINNA R GARSON S TAHA F | 2009 | Ann Chit Plast Esther2009，54，4： | 1 |
| 12 | Haloperidol ondansetron for the prevention of postoperative nausea and vomiting following gynaecological surgery 显示文摘 | Aouad M T Siddik-Sayyid S M Taha S K | 2007 | Eur J Anaesthe-siol2007，24，2： | 1 |
| 13 | Pre-oxygenation:comparison of maximal breathing and tidal volume breathing techniques显示文摘 | BARAKA A S TAHA S K AOUAD M T | 1999 | Anesthesiology1999，91，3： | 1 |
| 14 | Copper transfer modeling through an anofiltration membrane in the case of ternary aqueous solution显示文摘 | Mehiguene K Taha S Gondrexon N | 2002 | Desalination2002，127，： | 1 |
| 15 | Normal limits of ST segment measurements in posterior ECG leads显示文摘 | Taha B Reddy S Agarwal J | 1998 | J Electrocardiol1998，，： | 1 |
| 16 | Biosorption of methylene blue from aqueous solution by nonviable Aspergillus fumigatus显示文摘 | Abdallah R Taha S | 2012 | Chemical Engineering Journal2012，，195196： | 1 |
| 17 | A study of annealing stage in AI-Mn (3004) alloy after cold rolling using positron annihilation lifetime technique and Vickers microhardness measurements显示文摘 | GOMAA E MOHSEN M TAHA A S | 2003 | Materials Science and Engineering A2003，362，12： | 1 |
| 18 | Crack propagation and fracture of plain concrete beams subjected to shear and compression 显示文摘 | SWARTZ S E TAHA N M | 1991 | ACI Structural Journal1991，88，2： | 1 |
| 19 | A linearly implicit conservative scheme for the coupled Nonlinear Schrodinger equation显示文摘 | Ismail M S Thiab R Taha | 2007 | Mathematics and Computers in Simulation2007，74，45： | 1 |
| 20 | Mechanical,Fracture,and Microstructural Investigations of Rubber Concrete显示文摘 | REDA TAHA M M EL-DIEB A S ABD EL-WAHAB M A | 2008 | Journal of Materials in Civil Engineering2008，20，10： | 1 |
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