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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Nat Med:靶向两分子或有助于彻底治愈白血病显示文摘科学家在癌细胞内发现两个信号蛋白能够让癌细胞抵抗化疗。研究表明阻断这两种蛋白能够增强化疗对人类白血病小鼠模型的治疗效果。相关研究结果发表在国际学术期刊NatureMedicine上。研究人员发现在治疗中阻断c-Fos和Dusp1这两个蛋白能够治愈一些受激酶驱动且抵抗治疗的白血病和实体瘤。 | Meenu Kesarwani, Zachary Kincaid, Ahmed Gomaa, Erika Huber, Sara Rohrabaugh, Zain Siddiqui, Muhammad F Bouso, Kakajan Komurov, James C Mulloy, Jose A Cancelas, H Leighton Grimes Mohammad Azam Tahir Latif Ming Xu H Leighton Grimes Mohammad Azam | 2017 | 现代生物医学进展2017，17，17： | 4 |
| 3 | Granular cell tumour of the soft tissues:a case report and literature review显示文摘 | Qureshi N A Tahir M Carmichael A R | 2006 | Int Semin Surg Oncol2006，24，3： | 1 |
| 4 | Evaluation and rehabilitation of concrete pier显示文摘 | BUBSHAIT A A TAHIR B M | 1997 | Journal of Performance of Constructed Facilities1997，11，3： | 1 |
| 5 | MEPR venus EEPR values in open supermarket refrigerated display cabinets 显示文摘 | Tahir A Bansal P K | 2005 | Applied Thermal Engineering2005，，25： | 1 |
| 6 | HEDgeHOB: high-energy density matter generated by heavy ion beams at the future facility for antiprotons and ion research显示文摘 | Tahir N A Spillera P Shutov A | 2007 | Nuclear Instruments and Methods in Physics Research A2007，577，12： | 1 |
| 7 | Multiscale local phase quantization for robust component-based face recognition using kernel fusion of multiple descriptors 显示文摘 | Chan C H Tahir M A Kittler J | 2013 | IEEE Transactions on Pattern Analysis and Machine Intelligence2013，35，5： | 1 |
| 8 | Properties of some thermally modified wood species显示文摘 | BAKAR B F A HIZIROGLU S TAHIR P M | | 0，，： | 1 |
| 9 | Finite element modeling of crack propagation in metal powder compaction using Mohr-Coulomb and Elliptical Cap yield criteria显示文摘 | Tahir M S Arffin A K Anuar M S | 2010 | Powder Techn2010，202，13： | 1 |
| 10 | Design and evaluation of safety measures using a newly proposed显示文摘 | Faisal I Khana Tahir Husaina S A Abbasib | 2002 | Journal of Loss Prevention in the Process Industries2002，15，3： | 1 |
| 11 | Denitriflcation losses from an irrigated sandy - clay loam under a wheat - maize cropping system receiving different fertilizer treatments显示文摘 | Mahmood T Tahir G R Malik K A | 1998 | Biol Fertil Soils1998，26，： | 1 |
| 12 | SCAP a new methodology for safety management显示文摘 | Faisal I Khana Tahir Husaina S A Abbasib | 2001 | Journal of Hazardous Materials2001，87，： | 1 |
| 13 | Person re-identifica- tion in crowd 显示文摘 | Mazzon R Tahir S F Cavallaro A | 2012 | Pattern Recognition Letters2012，33，14： | 1 |
| 14 | The role of caveolin-1 in prostate cancer:clinical implications显示文摘 | THOMPSON T C TAHIR S A LI L | 2010 | Prostate Cancer and Prostatic Diseases2010，13，1： | 1 |
| 15 | Calcined sodium nitrate/natural phosphate:an extremely active catalyst for the easy synthesis of chalcones in heterogeneous media显示文摘 | Sebti S Solhy A Tahir R | | 0，，： | 1 |
| 16 | N-(4-Chlorobenzoyl)-N'-(3 fluorophenyl)thiourea 显示文摘 | OTHMAN N E A TAHIR M I M YAMIN B M | 2010 | Acta Crystall Section E: Struct Rep Online2010，66，9： | 1 |
| 17 | Chrysin suppresses renal carcinogenesis via amelioration of hyperproliferation, oxidative stress and inflammation: plausible role of NF-kappa B显示文摘 | REHMAN M U TAHIR M KHAN A Q | 2013 | Toxicol Lett2013，216，23： | 1 |
| 18 | A new susceptibility locus for myocardial infarction, hypertension, type 2 diabetes mellitus, and dyslipidemia on chromosome 12q24显示文摘 | Wakil S M Muiya N P Tahir A I | 2014 | Dis Markers2014，，29： | 1 |
| 19 | Glyeine transporter GLYT1 is essential for glycine-mediated protection of human intestinal epithelial cells against oxidative damage 显示文摘 | Howard A Tahir I Javed S | 2010 | J Physiol2010，588，6： | 1 |
| 20 | The role of caveolin-1 in prostate cancer:clinical implications显示文摘 | Thompson T C Tahir S A Li L | 2010 | Prostate Cancer Prostatic Dis2010，13，1： | 1 |
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