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| 1 | Transarterial chemoembolization and bland embolization for hepatocellular carcinoma显示文摘Transarterial chemoembolization(TACE)is the first line treatment for patients with intermediate stage hepatocellular carcinoma but is also increasingly being used for patients on the transplant waiting list to prevent further tumor growth.Despite its widespread use,TACE remains an unstandardized procedure,with variation in type and size of embolizing particles,type and dose of chemotherapy and interval between therapies.Existing evidence from randomized controlled trials suggest that bland transarterial embolization(TAE)has the same efficacy with TACE.In the current article,we review the use of TACE and TAE for hepatocellular carcinoma and we focus on the evidence for their use. | Emmanuel A Tsochatzis Evangelia Fatourou James O'Beirne Tim Meyer Andrew K Burroughs | 2014 | World Journal of Gastroenterology2014，20，12： | 18 |
| 2 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 3 | EASL and mRECIST responses are independent prognostic factors for survival in hepatocellular cancer patients treated with transarterial embolization显示文摘 | Roopinder Gillmore Sam Stuart Amy Kirkwood Ayshea Hameeduddin Nick Woodward Andrew K. Burroughs Tim Meyer | 2011 | Journal of Hepatology2011，，6： | 3 |
| 4 | A Systematic Review of Microvascular Invasion in Hepatocellular Carcinoma: Diagnostic and Prognostic Variability显示文摘 | Manuel Rodríguez-Perálvarez Tu Vinh Luong Lorenzo Andreana Tim Meyer Amar Paul Dhillon Andrew Kenneth Burroughs | 2013 | Annals of Surgical Oncology2013，，1： | 3 |
| 5 | Clinical outcomes of radiofrequency ablation, percutaneous alcohol and acetic acid injection for hepatocelullar carcinoma: A meta-analysis显示文摘 | Giacomo Germani Maria Pleguezuelo Kurinchi Gurusamy Tim Meyer Graziella Isgrò Andrew Kenneth Burroughs | 2010 | Journal of Hepatology2010，，3： | 2 |
| 6 | Transarterial Therapy for Hepatocellular Carcinoma: Which Technique Is More Effective? A Systematic Review of Cohort and Randomized Studies显示文摘 | Laura Marelli Rosa Stigliano Christos Triantos Marco Senzolo Evangelos Cholongitas Neil Davies Jonathan Tibballs Tim Meyer David W. Patch Andrew K. Burroughs | 2007 | CardioVascular and Interventional Radiology2007，，1： | 2 |
| 7 | Are there opportunities for chemotherapy in the treatment of hepatocellular cancer?显示文摘 | Uzma Asghar Tim Meyer | 2011 | Journal of Hepatology2011，，3： | 1 |
| 8 | Transarterial embolization as neo‐adjuvant therapy pretransplantation in patients with hepatocellular carcinoma显示文摘 | Emmanuel Tsochatzis Matteo Garcovich Laura Marelli Vassilis Papastergiou Evangelia Fatourou Manuel L. Rodriguez‐Peralvarez Giacomo Germani Neil Davies Dominic Yu Tu Vinh Luong Amar P. Dhillon Douglas Thorburn David Patch James O’Beirne Tim Meyer Andrew K. | 2013 | Liver Int2013，，6： | 1 |
| 9 | The CpG Island Methylator Phenotype: What’s in a Name?显示文摘 | Laura A.E. Hughes Veerle Melotte Joachim de Schrijver Michiel de Maat Vincent T.H.B.M. Smit Judith V.M.G. Bovée Pim J. French Piet A. van den Brandt Leo J. Schouten Tim de Meyer Wim van Criekinge Nita Ahuja James G. Herman Matty P. Weijenberg Manon van En | 2013 | Cancer Research2013，，： | 1 |
| 10 | Transarterial Therapy for Hepatocellular Carcinoma: Which Technique Is More Effective? A Systematic Review of Cohort and Randomized Studies显示文摘 | Laura Marelli Rosa Stigliano Christos Triantos Marco Senzolo Evangelos Cholongitas Neil Davies Jonathan Tibballs Tim Meyer David W. Patch Andrew K. Burroughs | 2007 | CardioVascular and Interventional Radiology2007，，1： | 1 |
| 11 | Recreational tourism injuries among visitors to New Zealand:an exploratory analysis using hospital discharge data显示文摘 | Tim Bentley Denny Meyer | | 0，，22： | 1 |
| 12 | Recreational tourism injuries amongvisitors to New Zealand: an exploratory analysis using hospital discharge data显示文摘 | Tim Bentley Denny Meyer and Stephen Page | 2001 | Tourism Management2001，22，4： | 1 |
| 13 | Recreational tourism injuries among visitors to New Zealand: an exploratory analysis using hospital discharge data显示文摘 | Tim Bentley Denny Meyer Stephen Page David Chalmers | 2001 | Tourism Management2001，，4： | 1 |
| 14 | Transarterial Therapy for Hepatocellular Carcinoma: Which Technique Is More Effective? A Systematic Review of Cohort and Randomized Studies显示文摘 | Laura Marelli Rosa Stigliano Christos Triantos Marco Senzolo Evangelos Cholongitas Neil Davies Jonathan Tibballs Tim Meyer David W. Patch Andrew K. Burroughs | 2007 | CardioVascular and Interventional Radiology2007，，1： | 1 |
| 15 | Transarterial Therapy for Hepatocellular Carcinoma: Which Technique Is More Effective? A Systematic Review of Cohort and Randomized Studies显示文摘 | Laura Marelli Rosa Stigliano Christos Triantos Marco Senzolo Evangelos Cholongitas Neil Davies Jonathan Tibballs Tim Meyer David W. Patch Andrew K. Burroughs | 2007 | CardioVascular and Interventional Radiology2007，，1： | 1 |
| 16 | Transarterial Therapy for Hepatocellular Carcinoma: Which Technique Is More Effective? A Systematic Review of Cohort and Randomized Studies显示文摘 | Laura Marelli Rosa Stigliano Christos Triantos Marco Senzolo Evangelos Cholongitas Neil Davies Jonathan Tibballs Tim Meyer David W. Patch Andrew K. Burroughs | 2007 | CardioVascular and Interventional Radiology2007，，1： | 1 |
| 17 | The CpG Island Methylator Phenotype: What’s in a Name?显示文摘 | Laura A.E. Hughes Veerle Melotte Joachim de Schrijver Michiel de Maat Vincent T.H.B.M. Smit Judith V.M.G. Bovée Pim J. French Piet A. van den Brandt Leo J. Schouten Tim de Meyer Wim van Criekinge Nita Ahuja James G. Herman Matty P. Weijenberg Manon van En | 2013 | Cancer Research2013，，19： | 1 |
| 18 | Earthquake devastation and recovery in tourism:the Taiwan case显示文摘 | Tim Bentley Denny Meyer Stephen Page | 2001 | Tourism Management2001，22，4： | 1 |
| 19 | Transarterial embolization as neo‐adjuvant therapy pretransplantation in patients with hepatocellular carcinoma显示文摘 | Emmanuel Tsochatzis Matteo Garcovich Laura Marelli Vassilis Papastergiou Evangelia Fatourou Manuel L. Rodriguez‐Peralvarez Giacomo Germani Neil Davies Dominic Yu Tu Vinh Luong Amar P. Dhillon Douglas Thorburn David Patch James O’Beirne Tim Meyer Andrew K. | 2013 | Liver Int2013，，6： | 1 |
| 20 | Clinical outcomes of radiofrequency ablation, percutaneous alcohol and acetic acid injection for hepatocelullar carcinoma: A meta-analysis显示文摘 | Giacomo Germani Maria Pleguezuelo Kurinchi Gurusamy Tim Meyer Graziella Isgrò Andrew Kenneth Burroughs | 2010 | Journal of Hepatology2010，，3： | 1 |
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