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| 1 | Biodegradation behavior of ultra-high-strength hydroxyapatite/poly (l-lactide) composite rods for internal fixation of bone fractures显示文摘 | Taizo F Yoshitaka M Tsunoru Y | 2000 | Biomaterials2000，21，9： | 1 |
| 2 | Food content of ubiquinol-10 and ubiquinone-10 in the Japanese diet显示文摘 | HIROSHI K KENJI F TAIZO K | 2008 | Journal of Food Composition and Analysis2008，21，： | 1 |
| 3 | Biodegradation behavior of ultra-high-strength hydroxyapatite/poly (L-lactide) composite rods for internal fixation of bone fractures显示文摘 | TAIZO F YOSHITAKA M TSUNORU Y | 2000 | Biomaterials2000，21，9： | 1 |
| 4 | A specific gene-expression signature quantifies the degree of hepatic fibrosis in patients with chronic liver disease显示文摘AIM: To study a more accurate quantification of hepatic fibrosis which would provide clinically useful information for monitoring the progression of chronic liver disease. METHODS: Using a cDNA microarray containing over 22 000 clones, we analyzed the gene-expression profiles of non-cancerous liver in 74 patients who underwent hepatic resection. We calculated the ratio of azan- stained: total area, and determined the morphologic fibrosis index (MFI), as a mean of 9 section-images. We used the MFI as a reference standard to evaluate our method for assessing liver fibrosis. RESULTS: We identified 39 genes that collectively showed a good correlation (r > 0.50) between gene-expression and the severity of liver fibrosis. Many of the identified genes were involved in immune responses and cell signaling. To quantify the extent of liver fibrosis, we developed a new genetic fibrosis index (GFI) based on gene-expression profiling of 4 clones using a linear support vector regression analysis. This technique, based on a supervised learning analysis, correctly quantified the various degrees of fibrosis in both 74 training samples (r = 0.76, 2.2% vs 2.8%, P < 0.0001) and 12 independent additional test samples (r = 0.75, 9.8% vs 8.6%, P < 0.005). It was far better in assessing liver fibrosis than blood markers such as prothrombin time (r = -0.53), type Ⅳ collagen 7s (r = 0.48), hyaluronic acid (r = 0.41), and aspartate aminotransferase to platelets ratio index (APRI) (r = 0.38). CONCLUSION: Our cDNA microarray-based strategy may help clinicians to precisely and objectively monitor the severity of liver fibrosis. | Tohru Utsunomiya Masahiro Okamoto Shigeki Wakiyama Masaji Hashimoto Kengo Fukuzawa Takahiro Ezaki Shinichi Aishima Yasuji Yoshikawa Taizo Hanai Hiroshi Inoue Graham F Barnard Masaki Mori | 2007 | World Journal of Gastroenterology2007，13，3： | 1 |
| 5 | Chemical synthesis of poly-g-glutamic acid by polycondensation of g-glutamic acid dimer: synthesis and reaction of poly-g-glutamic acid methyl ester显示文摘 | FUMIO S TAIZO F TAKESHI E | 2001 | Journal of Polymer Science Part A: Polymer Chemistry2001，39，： | 1 |
| 6 | 显示文摘 | Taizo F Masuya I | 2002 | Organic Process Research &Development2002，6，3： | 1 |
| 7 | Bone bonding ability of a new biodegradable composite for internal fixation of bone fractures显示文摘 | Taizo F Yoshitaka M Tsunoru Y | 2000 | Clin Orthop2000，379，： | 1 |
| 8 | Biodegradation behavior of ultra-high-strength hydeoxyapatite/poly ( L-lactide) composite rods for internal fixation of bone fractures显示文摘 | Taizo F Yoshimura M Tsunoru Y | 2000 | Biomaterials2000，21，： | 1 |
| 9 | Biodegradation behavior of ultra-high-strength hydroxyapatite/poly (L-lactide) composite rods for internal fixation of bone fractures显示文摘 | YOSHITAKA M TSUNORU Y | 2000 | Biomaterials2000，21，9： | 1 |
| 10 | Bone bonding ability of a new biodegradable composite for internal fixation of bone fracture 显示文摘 | Taizo F Yoshitaka M Tsunoru Y | 2000 | Clin Orthop2000，379，4： | 1 |
| 11 | (S)-3-methyl-2-phenylbutylamine, a versatile agent to resolve chiral, racemic carboxylic acids 显示文摘 | Yasuo C Taizo F Masaya I | 2002 | Organic Process Resetch & Development2002，6，： | 1 |
| 12 | Biodegradation behavior of ultra-high-strength hydroxyapatite/poly (L-lactide) composite rods for internal fixation of bone fractures 显示文摘 | Taizo F Yoshimura M Tsunoru Y | 2000 | Biomaterials2000，21，： | 1 |
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