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| 1 | Intraductal endoscopic radiofrequency ablation for the treatment of hilar non-resectable malignant bile duct obstruction显示文摘AIM: To evaluate the safety and technical success of endoscopic radiofrequency ablation(RFA) for palliative treatment of malignant hilar bile duct obstruction. METHODS: In this study, a recently CE and FDA-approved endoscopic RFA catheter was first tested in an ex vivo pig liver model to study the effect of electrosurgical variables on the extent of the area of induced necrosis. Subsequently, a retrospective analysis was conducted of all patients treated with endoscopic RFA for malignant biliary obstruction at our center between February 2012 and April 2013. All patients received an additional plastic stent implantation into the biliary tree following RFA. RESULTS: In the pig model, ablation time of 60-90 seconds using the bipolar soft coagulation mode at 8-10 watts with an effect of 8 was found to be the most feasible setting. Twelve patients(5 females, 7 males; mean age, 70 years) underwent 19 endoscopic RFA(range, 1-5) sessions. Deployment of RFA was successful in all patients. Systemic chemotherapy was administered in four patients. We observed biliary bleeding 4-6 wk after the intervention in three cases and two of these patients died: in one patient, spontaneous hemobilia occurred, whereas bleeding started during stent extraction in the other. In the third patient, bleeding was stopped by insertion of a non-covered self-expanding metal stent. Another three patients developed cholangitis during follow-up. Seven patients died during follow-up and median survival was 6.4 mo(95%CI: 0.05-12.7) from the time of the first RFA. CONCLUSION: Endoscopic RFA is an easy to perform and technically highly successful procedure. However, hemobilia possibly associated with RFA occurred in three of our patients. Therefore, larger prospective studies are needed to further evaluate the safety and efficacy of this promising new method. | Andrea Oliver Tal Johannes Vermehren Mireen FriedrichRust Jrg Bojunga Christoph Sarrazin Stefan Zeuzem Jrg Trojan Jrg Gerhard Albert | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，1： | 18 |
| 2 | Anaerobic Ammonia - oxidizing Bacteria and Related Activity in Baltimore Inner Harbor Sedi2ment 显示文摘 | Tal Y Watts J E M Schreier H J | 2005 | Applied and Environmental Microbiology2005，71，4： | 1 |
| 3 | S-Adenosylmethionine and methylation显示文摘 | CHang PK Gordon RK Tal J | 1996 | FASEB J1996，10，4： | 1 |
| 4 | Heterotopic pregnancy after ovulation induction and assisted reproductive technologies: a literature reviewfrom 1971 to 1993 显示文摘 | Tal J Haddad S Gordon N | 1996 | Fertility and Sterility1996，66，1： | 1 |
| 5 | A method in graph theory显示文摘 | BONDY J A CHV(A)TAL V | | 0，，02： | 1 |
| 6 | Servomotors take piezoceramic transducers for a ride显示文摘 | TAL J | 1999 | Machine design1999，9，12： | 1 |
| 7 | Glutathione conjugation: a detoxification pathway for fenoxapropethyl in barley, crabgrass, oat and wheat显示文摘 | TAL J A ROMANO M L STEPHENSON G R | 1993 | Pestic Biochem Physiol1993，46，： | 1 |
| 8 | Heterotopic pregnancy after ovulation induction and assisted reproductive technologies:a literature review from 1971-1993显示文摘 | Tal J Heddad S Gordon N | 1996 | Fertil Steril1996，66，： | 1 |
| 9 | Heterotopic pregnancy after ovulation and assisted reproductive technologies:a literature review from 1971~1993显示文摘 | Haddad S Gorodon N | 1996 | Fertil Steril1996，66，1： | 1 |
| 10 | BOXTREE: A Hierarchical Representation for Surfaces in 3D 显示文摘 | Gill Barequet Bernard Chazelle Leonidas J Guibas Joseph S B Mitchell Ayellet Tal | 1996 | Computer Graphics Forum1996，15，3： | 1 |
| 11 | Effects of 2-month ozone expo snre in spinach leaves on photosynthesis,antioxidant systems and lipid peroxidation显示文摘 | Calatayud A Iglesias D J Talón M | 2003 | Plant Physiology and Biochemistry2003，41，9： | 1 |
| 12 | Extra-territorial pain in rats with a peripheral mononeuropathy: mechano-hyperalgesia and mechano-allodynia in the territory of an uninjured nerve显示文摘 | Tal M Bennett G J | 1994 | Pain1994，57，： | 1 |
| 13 | Tonic seizures : a diagnostic clue of anti-LGI1 encephalitis? 显示文摘 | Andrade DM Tal P Dalmau J | 2011 | Neurolo- gy2011，76，15： | 1 |
| 14 | S-Adenosylmethionine and methylation显示文摘 | Chiang P K Gordon R K Tal J | 1996 | FASEB J1996，10，4： | 1 |
| 15 | Randomized trial of radiotherapy versus concurrent chemoradiotherapy followed by adjuvant chemotherapy in patients with American Joint Committee on Cancer/International Union against cancer stage III and IV nasopharyngeal cancer of the endemic variety显示文摘 | Wee J Tan EH Tal BC | 2005 | J Clin Oncol2005，23，27： | 1 |
| 16 | Non -enzymatic conjugation of fenoxaprop - ethyl with glutathione and eysteine in several grass spe- eies显示文摘 | Tal J A Hall J C Stephenson G R | 1995 | Weed Research1995，35，3： | 1 |
| 17 | Tree search algorithm for assigning cooperating UAVs to multiple tasks显示文摘 | Steven J Rasmussen Tal Shima | | 0，，02： | 1 |
| 18 | Long-termoutcomes-mycophenolate mofetil treatment for lupus nephritis with addition of tacrolimus for resistant cases显示文摘 | Cortes-I-Iemandez J Torres-Salido M T Medrano A S e- tal | 2010 | Nephrol Dial Transplant2010，25，12： | 1 |
| 19 | Medical application of single chain antibodies显示文摘 | Huston JS McCarteny J Tal ME | 1993 | Intern Rev Immuno1993，10，： | 1 |
| 20 | Adeno-associated virus-based vectors in gene therapy显示文摘 | Tal J | 2000 | J Biomed Sci2000，7，： | 1 |
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