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| 1 | 利钠肽受体2的缺乏促进小鼠二叶主动脉瓣、主动脉瓣疾病、左心室功能不全以及升主动脉扩张显示文摘主动脉瓣疾病是无有效药物治疗的细胞介导的病变过程。C型利钠肽(C-type natriuretic peptide,CNP)抑制瓣膜间质细胞(valve interstitial cells,VIC)的肌纤维形成和成骨过程,并且在出现主动脉瓣狭窄时水平下调。然而,CNP信号是否调节体内主动脉瓣的健康状态尚不清楚。该研究旨在确定小鼠CNP信号通路的缺失是否导致主动脉瓣疾病加速发展。 | 刘青 叶鹏 Blaser MC Wei K Adams RL Zhou YQ Caruso LL Mirzaei Z Lam A Tam RK Zhang H Heximer SP Henkelman M Simmons CA | 2018 | 中华高血压杂志2018，26，1： | 3 |
| 2 | Gastroesophageal reflux disease after diagnostic endoscopy in the clinical setting显示文摘AIM: To investigate the outcome of patients with symptoms of gastroesophageal reflux disease (GERD) referred for endoscopy at 2 and 6 mo post endoscopy. METHODS: Consecutive patients referred for upper endoscopy for assessment of GERD symptoms at two large metropolitan hospitals were invited to participate in a 6-mo non-interventional (observational) study.The two institutions are situated in geographically and socially disparate areas. Data collection was by selfcompletion of questionnaires including the patient assessment of upper gastrointestinal disorders symptoms severity and from hospital records. Endoscopic finding using the Los-Angeles classification, symptom severity and it's clinically relevant improvement as change of at least 25%, therapy and socio-demographic factors were assessed. RESULTS: Baseline data were available for 266 patients and 2-mo and 6-mo follow-up data for 128 and 108 patients respectively. At baseline, 128 patients had erosive and 138 non-erosive reflux disease. Allmost all patient had proton pump inhibitor (PPI) therapy in the past. Overall, patients with non-erosive GERD at the index endoscopy had significantly more severe symptoms as compared to patients with erosive or even complicated GERD while there was no difference with regard to medication. After 2 and 6 mo there was a small, but statistically significant improvement in symptom severity (7.02 ± 5.5 vs 5.9 ± 5.4 and 5.5 ± 5.4 respectively); however, the majority of patients continued to have symptoms (i.e. , after 6 mo 81% with GERD symptoms). Advantaged socioeconomic status as well as being unemployed was associated with greater improvement. CONCLUSION: The majority of GORD patients receive PPI therapy before being referred for endoscopy even though many have symptoms that do not sufficiently respond to PPI therapy. | Nora B Zschau Jane M Andrews Richard H Holloway Mark N Schoeman Kylie Lange William CE Tam Gerald J Holtmann | 2013 | World Journal of Gastroenterology2013，19，16： | 2 |
| 3 | Non-structural Fuzzy Decision Support System for Evaluation of Construction Safety Management System显示文摘 | Tam C M Tong Thomas K L Chiu Gerald C W Fung Ivan W H | 2002 | International Journal of Project Management2002，，20： | 1 |
| 4 | Microbial population dynamics and enzyme activities during composting 显示文摘 | Tiquia S M Wan J H C Tam N F Y | 2002 | Compost Science and Utilization2002，10，2： | 1 |
| 5 | Multimode project scheduling based on particle swarm optimization显示文摘 | Zhang H Tam C M Li H | | 0，，02： | 1 |
| 6 | Microbial population dynamics and enzyme activities during omposting 显示文摘 | Tiquia S M Wan J H C Tam N F Y | 2002 | Compost Science and Utilization2002，10，2： | 1 |
| 7 | Hirschsprung's disease显示文摘 | Kenny S E Tam P K H Garcia-Barcelo M | 2010 | Semin Pedlatr Surg2010，19，3： | 1 |
| 8 | A reliability- based stochastic traffic assignment model for net- work with multiple user classes under uncertainty in demand显示文摘 | SHAO H LAM W H K TAM M L | 2006 | Network and Spatial Economics2006，，6： | 1 |
| 9 | Biosorption and bioreduction of Cr(VI) by a microalgal isolate, Chlorella miniata显示文摘 | Han X Wong Y S Wong M H Tam N F Y | 2007 | Journal of Hazardous Materials2007，146，12： | 1 |
| 10 | A reliability-based stochastic traffic assignment model for network with multiple user classes under uncertainty in demand 显示文摘 | Shao H Lam W H K Tam M L | 2006 | Networks and Spatial Economics2006，6，3： | 1 |
| 11 | Sensitivity analysis with the FDTD method on structured grids显示文摘 | Nikolova N K Tam H W Bakr M H | 2004 | IEEE Transactions on Microwave Theory and Techniques2004，5，21： | 1 |
| 12 | Demand Driven traffic assignment problem based on travel time reliability显示文摘 | Shao H Lam W H K Tam M L | 2006 | Transportation Research Record2006，1985，： | 1 |
| 13 | Internal governance mechanisms and firm performance in China显示文摘 | Hu H W Tam O K Tan M G S | 2010 | Asia Pacific Jour- nal of Management2010，27，： | 1 |
| 14 | Multimode project scheduling based on particle swarm optimization 显示文摘 | Zhang H Tam C M Li H | 2006 | Computer-Aided Civil and Infrastructure Engineering2006，21，： | 1 |
| 15 | Comparison of two non-parametric models for daily traffic forecasting in Hong Kong 显示文摘 | LAM W H K TANG Y F TAM M L | 2006 | Journal of Forecasting2006，25，3： | 1 |
| 16 | A reliability-based stochastic traffic assignment model for network with multiple user classes under uncertain in demand 显示文摘 | Shao H Lain W H K Tam M L | 2006 | Network and Spatial Economics2006，6，34： | 1 |
| 17 | A reliability-based stochastic traffic assignment model for network with multiple user classes under uncertainty in demand显示文摘 | Shao H Lam W H K Tam M L | | 0，，3： | 1 |
| 18 | Using automatic vehicle identification data for travel time estimation in Hong Kong 显示文摘 | TAM M L LAM W H K | 2008 | Transportmetrica2008，4，3： | 1 |
| 19 | A Carbonation Prediction Model for Accelerated Carbonation Testing o{ Concrete显示文摘 | Loo Y H Chin M S Tam C T | 1994 | Magaz Concr Res1994，88，4： | 1 |
| 20 | Microbial population dynamics and enzyme activities during composting显示文摘 | Tiquia S M Wan J H C Tam N F Y | 2002 | Compost Science and Utilization2002，10，2： | 1 |
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