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| 1 | Procedural complexity independent of P2Y12 reaction unit(PRU)values is associated with acute in situ thrombosis in Pipeline flow diversion of cerebral aneurysms显示文摘background Acute in situ thrombosis is an ischaemic phenomenon during Pipeline embolisation device(PED)procedures with potentially high morbidity and mortality.There is controversy regarding the role of platelet function testing with P2Y12 assay as a predictor of intraprocedural thromboembolic events.There is limited knowledge on whether procedural complexity influences these events.Methods Data were collected retrospectively on 742 consecutive PED cases at a single institution.Patients with intraprocedural acute thrombosis were compared with patients without these events.results A cohort of 37 PED cases with acute in situ thrombosis(mean age 53.8 years,mean aneurysm size 8.4 mm)was matched with a cohort of 705 PED cases without intraprocedural thromboembolic events(mean age 56.4 years,mean aneurysm size 6.9 mm).All patients with in situ thrombosis received intra-arterial and/or intravenous abciximab.The two groups were evenly matched in patient demographics,previous treatment/subarachnoid hemorrhage(SAH)and aneurysm location.There was no statistical difference in postprocedural P2Y12 reaction unit(PRU)values between the two groups,with a mean of 156 in the in situ thrombosis group vs 148 in the control group(p=0.5894).Presence of cervical carotid tortuosity,high cavernous internal carotid artery grade,need for multiple PED and vasospasm were not significantly different between the two groups.The in situ thrombosis group had statistically significant longer fluoroscopy time(60.4 vs 38.4 min,p<0.0001),higher radiation exposure(3476 vs 2160 mGy,p<0.0001),higher rates of adjunctive coiling(24.3% vs 8.37%,p=0.0010)and higher utilisation of balloon angioplasty(37.8% vs 12.2%,p<0.0001).Clinically,the in situ thrombosis cohort had higher incidence of major and minor stroke,intracerebral haemorrhage and length of stay.Conclusions Predictors of procedural complexity(higher radiation exposure,longer fluoroscopy time,adjunctive coiling and need for balloon angioplasty)are associated with acute thrombotic events during PED placement,independent of PRU values. | Bowen Jiang Matthew T Bender Erick M Westbroek Jessica K Campos Li-Mei Lin Risheng Xu Rafael J Tamargo Judy Huang Geoffrey P Colby Alexander L Coon | 2018 | Stroke & Vascular Neurology2018，3，3： | 2 |
| 2 | Inflammation in stroke and focal cerebral isehemia显示文摘 | HUANG J UPADHYAY UM TAMARGO RJ | 2006 | Surgical Neurology2006，66，3： | 1 |
| 3 | Inflammation in stroke and focal cerebral ischemia显示文摘 | Huang J Upadhyay U M Tamargo R | 2006 | Surg Neurol2006，66，3： | 1 |
| 4 | Cardiac electrophysiolog- ical effects of nitric oxide显示文摘 | Tamargo J Caballero R G6mez R | 2010 | Cardiovasc Res2010，87，4： | 1 |
| 5 | Inflammation in stroke and focal cerebral ischemia 显示文摘 | HUANG J UPADHYAY UM TAMARGO RJ | 2006 | Surg Neurol2006，66，3： | 1 |
| 6 | Drug-induced Torsade de Pointes: From molecular biology to bedside 显示文摘 | Tamargo J | 2000 | Jpn J Pharmacol2000，83，1： | 1 |
| 7 | Moyamoya disease in children显示文摘 | Ibrahimi DM Tamargo R J Ahn ES | 2010 | Childs Nerv Syst2010，26，： | 1 |
| 8 | Inflammation in stroke and focal cerebral ischemia 显示文摘 | Huang J Upadhyay UM Tamargo RJ | 2006 | Surg Neurol2006，66，3： | 1 |
| 9 | Pharmacolo- gy of cardiac potassium channels显示文摘 | TAMARGO J CABALLERO R GOMEZ R | 2004 | Cardiovasc Res2004，62，1： | 1 |
| 10 | Inflammation in stroke and focal cerebral ischemia 显示文摘 | Huang J Upadhyay U M Tamargo R J | 2006 | Surg Neurol2006，66，3： | 1 |
| 11 | Inflammation in stroke and focal cerebral ischemia显示文摘 | Huang J Upadhyay UM Tamargo RJ | 2006 | Surg Neurol2006，66，3： | 1 |
| 12 | Inflammation in stroke and focal cerebral ischemic 显示文摘 | Huang J Upadhyay UM Tamargo R | 2006 | Sueg Neurol2006，66，3： | 1 |
| 13 | Pharmacology of cardiac potassium channels 显示文摘 | Tamargo J Caballero R Gomez R | 2004 | Cardiovasc Res2004，62，1： | 1 |
| 14 | Interstitial chemotherapy of the 9L gliosarcoma:controlled release polymers for drug delivery in the brain显示文摘 | Tamargo R J Myseros JS Epstein JI | 2003 | Cancer Res2003，63，2： | 1 |
| 15 | Old and new molecular mechanisms associated with platelet resistance to antithrombotics 显示文摘 | Farr A JL Tamargo J Mateos-Cdceres PJ | 2010 | Pharm Res2010，27，11： | 1 |
| 16 | Lipid - lowering therapy with statins, a new approach to antiarrhythmie therapy 显示文摘 | Tamargo J Caballero R Gomez R | 2007 | Phar- macol Ther2007，114，1： | 1 |
| 17 | Inflammation in stroke and focal cerebral ischemia 显示文摘 | Huang J Upadhyay UM Tamargo RJ | 2006 | Surg Neural2006，66，： | 1 |
| 18 | Inhibition of tumor angiogenesis显示文摘 | SIPOS E P TAMARGO R T WEINGART J D | 1994 | Ann N Y Acad Sci1994，732，： | 1 |
| 19 | Drug-induced torsade de pointes:from molecular biologyto bedside显示文摘 | Tamargo J | 2000 | Jpn J Pharmacol2000，83，1： | 1 |
| 20 | Inflammation in stroke and focal cerebral ischemia 显示文摘 | Huang J Upadhyay UM Tamargo RJ | 2006 | Surg Neurol2006，66，3： | 1 |
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