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| 1 | NKX2-3 and IRGM variants are associated with diseasesu sceptibility to IBD in Eastern European patients显示文摘AIM: To investigate variants of immunity-related GT-Pase family M (IRGM) and NKX2-3 genes and genotype-phenotype in Eastern European patients with inflammatory bowel disease (IBD).METHODS: We analyzed 1707 Hungarian and Czech subjects with Crohn’s disease (CD) (n = 810, age: 37.1 ± 12.6 years, duration: 10.7 ± 8.4 years) and ulcerative colitis (UC) (n = 428, age: 43.7 ± 15.0 years, duration: 12.6 ± 9.9 years), as well as 469 healthy controls. IRGM rs13361189, NKX2-3 rs10883365 and ECM1 rs13294 polymorphisms were tested by LightCy-cler allele discrimination. Detailed clinical phenotypes were determined by reviewing the medical charts. RESULTS: NKX2-3 rs10883365 variant allele was as-sociated with increased risk for CD (P = 0.009, OR = 1.24, 95% CI = 1.06-1.48) and UC (P = 0.001, OR = 1.36, 95% CI = 1.13-1.63), whereas variant IRGM allele increased risk for CD (P = 0.029, OR = 1.36, 95% CI = 1.03-1.79). In contrast, ECM1 rs13294 was not associat-ed with either CD or UC. In CD, the variant IRGM allele was associated with a colon-only location (P = 0.02, OR = 1.62, 95% CI = 1.07-2.44), whereas in UC, the ECM1 variant was associated with cutaneous manifestations (P = 0.002, OR = 3.36, 95% CI = 1.48-7.63). Variant alleles did not predict resistance to steroids or azathio-prine, efficacy of infliximab, or need for surgery. CONCLUSION: NKX2-3 and IRGM are susceptibility locifor IBD in Eastern European patients. Further studies are needed to confirm the reported phenotype-genotype associations. | Nora Meggyesi Lajos S Kiss Magdalena Koszarska Martin Bortlik Dana Duricova Laszlo Lakatos Tamas Molnar Martin Lenicek Libor Vítek Istvan Altorjay Maria Papp Zsolt Tulassay Pal Miheller Janos Papp Attila Tordai Hajnalka Andrikovics Milan Lukas Peter Laszlo Lakatos | 2010 | World Journal of Gastroenterology2010，16，41： | 2 |
| 2 | Reverse Engineering of Geometric Models-an Introduction显示文摘 | Martin R R Jordan C | 1997 | Computer-Aided Design1997，29，4： | 1 |
| 3 | Tower Crane Safety in the Construction Industry: a Hong Kong Study显示文摘 | Tama V W Y Fung I W H | 2011 | Safety Science2011，49，2： | 1 |
| 4 | Identification and partial characterization of β-1,3-glucanase from virus-infected cucumber cotyledons 显示文摘 | Repka V Tamas L Fischerova I | 1997 | Acta Virol1997，41，1： | 1 |
| 5 | Direct segmentation of smooth,multiple point regions显示文摘 | Pal B Tamas V | 2002 | Computer Science2002，，： | 1 |
| 6 | Comparative Study of Three Doses of Interferon Mpha - 2a in Chronic Active Hepatitis B显示文摘 | Tamas HC Lok ASF Carreno V | 1994 | J Viral Hepatitis1994，1，： | 1 |
| 7 | An application of the AHP in vendor selection of a telecommunications system 显示文摘 | Maggie C Y Tama V M Rao Tummala | 2001 | Omega2001，29，： | 1 |
| 8 | Micro- structural analysis of recycled aggregate con- crete produced from two-stage mixing ap- proach 显示文摘 | Tama V M Y Gao X F Tama C M | 2005 | Cement and Concrete Research2005，35，6： | 1 |
| 9 | Reverse engineering of geometric models--an introduction显示文摘 | TAMAS V A RALPH R M COXT J | 1997 | Computer Aided Design1997，29，4： | 1 |
| 10 | Reverse engineering of geometric models-An introduction显示文摘 | Tamas V Ralph R R Coxf J | 1997 | Computer-Aided Design1997，29，4： | 1 |
| 11 | Reverse engineering of geometric models-an introduction 显示文摘 | TAMAS V RALPH R M | 1997 | Computer Aided Design1997，29，4： | 1 |
| 12 | Diabetes mellitus at- tenuates the repolarization reserve in mammalian heart显示文摘 | Csaba L Laszlo V Tamas B | 2007 | Cardiovasc Res2007，73，3： | 1 |
| 13 | Methods to recover constant radius rolling ball blends in reverse engineering显示文摘 | Kos G Martin R R Tamas V | 2000 | Computer Aided Geometric Deign2000，17，2： | 1 |
| 14 | Reverse engineering of geometric models - an introduction 显示文摘 | TAMAS V RALPH R M JORDAN C | 1997 | Computer Aided Design1997，29，4： | 1 |
| 15 | Human serum amyloid P component attenuates the bacterial lipopolysaccharide- induced increase in blood-brain barrier permeability in mice 显示文摘 | Szilvia V Zolta'n U Tama's P | 2003 | Neuroselenee Letters2003，352，： | 1 |
| 16 | EGIS-7229, the new combined class Ⅲ antiarrhythmic agent lack of EAD inducing effect 显示文摘 | TAMAS B S Z JANOS M ANDRA V | 1999 | General Pharmacology1999，32，3： | 1 |
| 17 | Micro- structural analysis of recycled aggregate con- crete produced from two-stage mixing approach 显示文摘 | Tama V M Y Gao X F Tama C M | 2005 | Cement and Concrete Research2005，35，6： | 1 |
| 18 | STIM and Orai: the long-awaited constituents of store-operated calcium entry显示文摘 | Péter Várnai László Hunyady Tamas Balla | 2009 | Trends in Pharmacological Sciences2009，，3： | 1 |
| 19 | Microstructural analysis of recycled aggregate concrete produced from two-stage mixing approach 显示文摘 | Tama V W Y Gaob X F Tama C M | 2005 | Cement and Concrete Research2005，35，6： | 1 |
| 20 | Reverse engineering of geometric models-An introduction显示文摘 | Tamas V Ralph M Jordan C | 1997 | Computer Aided Design1997，29，4： | 1 |
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