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| 1 | Prevalence of SLC22A4, SLC22A5 and CARD15 gene mutations in Hungarian pediatric patients with Crohn’s disease显示文摘AIM: To investigate the frequency of the common NOD2/CARD15 susceptibility variants and two functional polymorphisms of OCTN cation transporter genes in Hungarian pediatric patients with Crohn’s disease (CD). METHODS: A cohort of 19 unrelated pediatric and 55 unrelated adult patients with Crohn’s disease and 49 healthy controls were studied. Genotyping of the three common CD-associated CARD15 variants (Arg702Trp, Gly908Arg and 1007finsC changes) with the SLC22A4 1672C→T, and SLC22A5 -207G→C mutations was performed by direct sequencing of the specifi c regions of these genes.RESULTS: At least one CARD15 mutation was present in 52.6% of the children and in 34.5% of the adults compared to 14.3% in controls. Surprisingly, strongly different mutation profi le was detected in the pediatric versus adult patients. While the G908R and 1007finsC variants were 18.4% and 21.1% in the pediatric group, they were 1.82% and 11.8% in the adults, and were 1.02% and 3.06% in the controls, respectively. The R702W allele was increased approximately two-fold in the adult subjects, while in the pediatric group it was only approximately 64% of the controls (9.09% in the adults, 2.63% in pediatric patients, and 4.08% in the controls). No accumulation of the OCTN variants was observed in any patient group versus the controls.CONCLUSION: The frequency of the NOD2/CARD15 susceptibility variants in the Hungarian pediatric CD population is high and the profile differs from the adult CD patients, whereas the results for SLC22A4 and SLC22A5 mutation screening do not confirm the assumption that the carriage of these genotypes means an obligatory susceptibility to CD. | Judit Bene Lili Magyari Gábor Talián Katalin Komlósi Beáta Gasztonyi Beáta Tari gnes Várkonyi Gyula Mózsik Béla Melegh | 2006 | World Journal of Gastroenterology2006，12，34： | 6 |
| 2 | Processing of Porous C ordierite Bodies by Starch Consolidation 显示文摘 | Aires H M Tari G Fonseca A T | 1998 | Materials Research Bulletin1998，33，10： | 1 |
| 3 | Influence of the Stabilizing Mechanism and Solid Loading on Slip Casting of Alumina 显示文摘 | Tari G Ferreira J M Lyckfeldt O | 1998 | Europ Ceram SOc1998，18，： | 1 |
| 4 | GRB2: a pivotal protein in signal transduction显示文摘 | Tari AM Lopez-Berestein G | 2001 | Semin Oncol2001，28，516： | 1 |
| 5 | Extraction of shape skeletons fiom grayscale images显示文摘 | | 1997 | Computer Vision and Image Understanding May1997，66，2： | 1 |
| 6 | The RAGE axis in early diabetic retinopathy显示文摘 | Barile G R Pachydaki S I Tari S R | 2005 | Invest Ophthalmol Vis Sci2005，46，8： | 1 |
| 7 | The Role of the Synergistic Phosphate Anion in Iron Transport by the Periplasmic Iron-binding Protein from Haemophilus Influenzae显示文摘 | Khan A G Shouldice S R Tari L W | | 0，，： | 1 |
| 8 | Synergy of polysaccharide mixtures in gelcasting of alumina 显示文摘 | Olhero S M Tari G Coimbra M A | 2000 | J Europ Ceram Soc2000，20，： | 1 |
| 9 | Salicylic acid increased al- dose reductase activity and sorbitol accumulation in tomato plants under salt stress 显示文摘 | Tari I Kiss G Deer A K | 2010 | Biologia Plantarum2010，54，4： | 1 |
| 10 | Liposome-incorporated Grb2 antisense oligodeoxynucleotide increases the survival of mice bearing bcr-abl-positive leukemia xenografts显示文摘 | Tari AM Gutierrez-puente Y Monaco G | 2007 | Int J Oncol2007，31，5： | 1 |
| 11 | Hydroponic treatment with salicylic acid decrease the effects of chilling injure in maize(zea maysl)plants显示文摘 | JANDA T SZALAI G TARI I | 1999 | Planta1999，，208： | 1 |
| 12 | Construct Validity of the Maslach Burnout Inventory-general Survey:A Two-sample Examination of Its Factor Structure and Correlates显示文摘 | Taris T W Schreurs P J G Schaufeli W B | 1999 | Work&Stress1999，13，3： | 1 |
| 13 | Influence of particle size distribution on colloidal processing of alumina显示文摘 | TARI G FERREIRA J M FONSECA A T | 1998 | J Eur Ceram Soc1998，18，： | 1 |
| 14 | GRB2:A pivotal protein in signal transduction显示文摘 | Tari AM Lopez-Berestein G | | 0，，05： | 1 |
| 15 | Comparison of depositional sequences and tectonic styles among the West African deepwater frontiers of western lvory Coast, southern Equatorial Guinea, and northern Namibla显示文摘 | Conterill K Tari G C Molnar J | 2002 | The Leading Edge2002，21，11： | 1 |
| 16 | Inhibition of Grb2 and Crkl proteins results in growth inhibition of Philadelphia chromosome positive leukemic cells显示文摘 | Tari AM Arlinghaus R Lopez-Berestein G | | 0，，2： | 1 |
| 17 | Hydroponic treatment with salicylic acid decrease the effects of chilling injury in maize(Zea Mays L) plants显示文摘 | Janda T Szalai G Tari I | 1999 | Planta1999，208，： | 1 |
| 18 | Reinforcement sensitivity theory at work: punishment sensitivity as a disposi- tional source of job-related stress 显示文摘 | van der Linden D Beckers D G J Taris T W | 2007 | European Journal of Personality2007，21，7： | 1 |
| 19 | Synergy of polysaccharide mixtures in gelcasting of alumina显示文摘 | OLHERO S M TARI G COIMBRA M A | 2000 | Journal of the European Ceramic Society2000，20，4： | 1 |
| 20 | Energy of polysaccharide mixtures in gelcasting of alumina显示文摘 | OLHERO S M TARI G COIMBRA M A | 2000 | J Eur Ceram Soc2000，20，4： | 1 |
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