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| 1 | Combined resection and radiofrequency ablation for multifocal hepatocellular carcinoma: Prognosis and outcomes显示文摘AIM: To analyze the combined treatment of resection and intraoperative radiofrequency ablation (RFA) for multifocal hepatocellular carcinoma in terms of prognosis and surgical outcomes.METHODS: This study was a retrospective case comparison study using prospectively collected data. The study covered the period from April 2001 to December 2006. The data of 200 patients with histologically confirmed hepatocellular carcinoma were reviewed. Nineteen patients (17 men and 2 women) having received resection in combination with RFA were chosen as subjects of the study (the combination group). Fiftyfour patients (43 men and 11 women) having received resection alone were selected for comparison (the resection group). The two groups matched tumor number and tumor size, and all the patients in the two groups displayed no tumor rupture, major vascular involvement and distant metastasis. Their demographics, preoperative assessment, disease recurrence patterns, overall survival and diseasefree survival were compared.RESULTS: In the combination group, the medianage was 65 years (range, 3477 years), the median tumor number was 3 (range, 29), and the median tumor size was 6 cm (range, 1.214 cm). In the resection group, the median age was 51.5 years (range, 2780 years, P = 0.003), the median tumor number was 3 (range, 29, P = 0.574), and the median tumor size was 6 cm (range, 114 cm, P = 0.782). The two groups were similar in characteristics of tumors and comorbidities, and had comparable results in preoperative liver function tests. All patients had ChildPugh class A status. Bilobar involvement occurred in 14 patients (73.6%) in the combination group and 3 patients (5.5%) in the resection group (P = 0.04). Six patients (32%) in the combination group and 35 patients (65%) in the resection group underwent major hepatectomy. Thirteen patients (68%) in the combination group and 19 patients (35%) in the resection group underwent minor hepatectomy (P = 0.012). The combination group had fewer major resections (32% vs 65%, P = 0.012), less blood loss (400 vs 657 mL, P = 0.007), shorter operation time (270 vs 400 min, P = 0.001), and shorter hospital stay (7 vs 8.5 d, P = 0.042). The two groups displayed no major differences in surgical complications (15.8% vs 31.5%, P = 0.24), disease recurrence (63.2% vs 50%, P = 0.673), hospital mortality (5.3% vs 5.6%, P = 1), and overall survival (53 vs 44.5 mo, P = 0.496).CONCLUSION: Safe and effective for selected patients with multifocal hepatocellular carcinoma, the combination of resection and intraoperative RFA widens the applicability of surgical intervention for the disease. | Tan To Cheung Kelvin K Ng Kenneth S Chok See Ching Chan Ronnie T Poon Chung Mau Lo Sheung Tat Fan | 2010 | World Journal of Gastroenterology2010，16，24： | 14 |
| 2 | Transient interference excision in over-the-horizon radar using adaptive time-frequency analysis显示文摘 | Xin G Hongbo S Tat S Y | 2005 | Geoscience and Remote Sensing IEEE Transactions on2005，43，4： | 1 |
| 3 | Self-assembled Nanocomposite of Organic-inorganic Hybrid显示文摘 | Hussein M Z B Zainal Z Tat O W S | 2000 | Journal of Chemistry2000，16，2： | 1 |
| 4 | The molecular triad OPG/RANK/RANKL:involvement in the orchestration of pathophysiological bone remodeling显示文摘 | Theoleyre S Wittrant Y Tat SK | | 0，，06： | 1 |
| 5 | The production of fatty acid isopropyl esters and their use as a diesel engine fuel显示文摘 | Wang Paul S Tat Mustafa E Van Gerpen Jon | 2005 | Journal of the American Oil Chemists'' Society2005，82，11： | 1 |
| 6 | The molecular triad OPG/RANK/RANKL: involvement in the or- chestration of pathophysiological bone remodeling 显示文摘 | Theoleyre S Wittrant Y Tat S K | 2004 | Cytokine Growth Factor Rev2004，15，6： | 1 |
| 7 | Strontium rane- late inhibits key factors affecting bone remodeling in hu- man osteoarthritic subchondral bone osteoblasts 显示文摘 | Tat S K Pelletier J P Mineau F | 2011 | Bone2011，49，3： | 1 |
| 8 | The molecular triad OPG/RANK/RANKL: involvement in the orchestration of pathophysiological bone remodeling显示文摘 | THEOLEYRE S WITTRANT Y TAT S K | 2004 | Cytokine Growth Fact or Rev2004，15，： | 1 |
| 9 | An effective method for the oxidation of aminofurazans to nitro-fura- zans 显示文摘 | Novikova Tat'yana S Mel'nikova Tat'yana M Kharitonova Olga V | 1994 | Mendeleev Commun1994，4，： | 1 |
| 10 | IL-6, RANKL, TNF-alpha/IL- 1: interrelations in bone resorption pathophysiology显示文摘 | Kwan Tat S Padrines M Theoleyre S | 2004 | Cytokine Growth Factor Rev2004，15，： | 1 |
| 11 | An effective method for oxidation of aminofurazans to nitrofurazazs显示文摘 | Tatyana S Novikova Tat' yana M Mel' nikova | 1994 | Mendeleeve communication1994，，： | 1 |
| 12 | The molecular triad OPG/RANK/ RANKL:involvement in the orchestration of pathophysiological bone re- modeling 显示文摘 | Theoleyre S Wittrant Y Tat SK | 2004 | Cytokine Growth Factor Rev2004，15，7： | 1 |
| 13 | The production of fatty acid isopropyl esters and their use as a diesel engine fuel 显示文摘 | WANG P S TAT M E GERPEN J V | 2005 | Journal of the American Oil Chemists Society2005，82，5： | 1 |
| 14 | Mutations in lipoprotein lipase that block binding to the endothelial cell transporter GPIHBP1 显示文摘 | Voss CV Davies BS Tat S | 2011 | Proc Natl Acad Sci U S A2011，108，19： | 1 |
| 15 | Design of lactide copolymers as biomaterials显示文摘 | Ouchi Tat S | 2004 | Polym Chem2004，42，3： | 1 |
| 16 | The production of fatty acid isopropyl esters and their use as a diesel engine fuel 显示文摘 | WANG PAUL S TAT MUSTAFA E VAN GERPEN J | 2005 | Journal of the American Oil Chemists'' Society2005，11，7： | 1 |
| 17 | The molecular triad OPG/RANK/RANKL:involvement in the orchestration of pathophysiological bone remodeling显示文摘 | Theoleyre S Wittrant Y Tat SK | 2004 | Cytokine Growth Factor Rev2004，15，6： | 1 |
| 18 | Olanzapine and venous thromboembolism显示文摘 | Hagg S Tatting P Spigset O | 2003 | Int Clin Psychopharmaco12003，18，5： | 1 |
| 19 | 11-6, rankl, Tnf-alpha/il-1: Interrelations in bone resorption pathophysiology 显示文摘 | Kwan tat S Padfines M Theoleyre S | 2004 | Cytokine Growth Factor Rev2004，15，1： | 1 |
| 20 | Assessing the role of the glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 (GPIHBP1) three-finger domain in binding lipoprotein lipase显示文摘 | BEIGNEUX A P DAVIES B S TAT S | 2011 | J Biol Chem2011，286，22： | 1 |
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