|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Thiopurine-methyltransferase variants in inflammatory bowel disease:Prevalence and toxicity in Brazilian patients显示文摘AIM:To analyze the prevalence of thiopurine-methyltransferase(TPMT)genotypes and their associationwith drug toxicity in inflammatory bowel disease(IBD)patients from southeastern Brazil.METHODS:A total of 219 consecutive patients with IBD,of which 146 had Crohn’s disease and 73 had ulcerative colitis,regularly seen at the outpatient unit of the Division of Gastroenterology at the University Hospital Pedro Ernesto of the State University of Rio de Janeiro,a tertiary referral center,were enrolled in this study from February 2009 to January 2011.We analyzed the presence of major TPMT genetic variants(TPMT*2,*3A,*3C)in IBD patients by means of a specific allele and RFLP-PCR.Genomic DNA was isolated from peripheral blood leukocytes by proteinase-K/Sodium Dodecyl Sulfate digestion and phenol-chloroform extraction.TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes were detected by real-time polymerase chain reaction followed by direct sequencing with specific primers.Clinical data were systematically recorded,and correlated with the genotype results.RESULTS:The distribution of the selected TPMT gene polymorphism TPMT*2(C238G),TPMT*3A(G460A/A719G),and TPMT*3C(A719G)genotypes was 3.6%,5.4%,and 7.7%of the patients,respectively.Among the side effects recorded from patients taking azathioprine,14 patients presented with pancreatitis and/or an elevation of pancreatic enzymes,while 6 patients had liver toxicity,and 2 patients exhibited myelosuppression/neutropenia.TPMT polymorphisms were detected in 37/219 patients(8 heterozygous for*2,11 heterozygous for*3A,and 18 heterozygous for*3C).No homozygotic polymorphisms were found.Despite the prevalence of the TPMT*3C genotype,no differences among the genotype frequencies were significant.Although no association was detected regarding myelotoxicity or hepatotoxicity,a trend towards the elevation of pancreatic enzymes was observed for TPMT*2 and TPMT*3C genotypes.CONCLUSION:The prevalence of TPMT genotypes was high among Brazilian patients.Variants genes*2and*3C may be associated with azathioprine pancreatic toxicity in a IBD southeastern Brazilian population. | Ana Teresa P Carvalho Barbara C Esberard Renata S B Fróes Davy C M Rapozo Ana B Grinman Tatiana A Simo Juliana C V C Santos Antonio José V Carneiro Luis Felipe Ribeiro-Pinto Heitor S P de Souza | 2014 | World Journal of Gastroenterology2014，20，12： | 3 |
| 2 | 显示文摘 | TATIANA A S HEIKE M SERGIY A P | 2001 | J Chromatogr A2001，907，： | 1 |
| 3 | Mass spectrometric survey of interganglionically transported ppeptides in Aplysia 显示文摘 | LI L J TATIANA P M REBECCA W G | 1998 | Peptides1998，19，8： | 1 |
| 4 | Free sterol compositions from the sea cucumbers Pseudostichopus tra- chus , Holothuria (Microtele) nobilis , Holothuria scabra, Trochos- toma orientale and Bathyplotes natans 显示文摘 | VALENTINE A S LJUDMILA P P TATIANA N M | 1998 | Comp Biochem Phys B1998，120，2： | 1 |
| 5 | The effect of strepto coccus mutans and candida glabrata on candida albi- cans biofilms formed on different surfaces显示文摘 | TATIANA P C DENG M D | 2008 | Ar- chives of Oral Biology2008，53，8： | 1 |
| 6 | Inhibitory Action of Aqueous Garlic Peel Extract on the Corrosion of Carbon Steel in HCl Solution显示文摘 | SIMONE S de A A P MICHELLE M P TATIANA L F | | 0，，： | 1 |
| 7 | Adaptation of fluorescent technique for genotyping with new microsatellite markers in common bean 显示文摘 | Oblessuc P R Tatiana de Campos Cardoso J M K | 2009 | Pesq agropec bras2009，44，6： | 1 |
| 8 | Improvement of Stress Tolerance of Wheat and Barley by Modulation of Expression of DREB/CBF Factors 显示文摘 | Sarah M Omid E Tatiana P | 2011 | Plant Biotechnology Journal2011，9，2： | 1 |
| 9 | Mean platelet volume on admission corre lates with impaired response to thrombolysis in patients with ST-eleva tion myocardial infarction显示文摘 | David P Tatiana B Morris M | 2010 | Platelets2010，21，： | 1 |
| 10 | Effects of a nuclear power plant thermal discharge on habitat complexity and fish community structure in Ilha Grande Bay,Brazil显示文摘 | TATIANA P T LEONARDO M N FRANCISCO G A | 2009 | Marine Environmental Research2009，68，： | 1 |
| 11 | Molecularly imprinted polymer membranes for substance-selective solidphase extraction from water by surface photo-grafting polymerization 显示文摘 | TATIANA A S HEIKE M SERGIY A P | 2001 | J Chromatography (A)2001，907，： | 1 |
| 12 | 显示文摘 | Tatiana A S Heike M Sergiy A P | 2001 | J Chromatography A2001，907，： | 1 |
| 13 | Pole to Equator Temperature Gradient for Coniacian Time,Late Cretaceous:Oxygen and Carbon Isotopic Data on the Koryak Upland and Hokkaido显示文摘The purpose of this study was to estimate the Coniacian latitudinal thermal gradient in the Northern Hemisphere.Both hemipelagic(ammonoids) and benthic(brachiopods and bivalves) ??18O and ??13С records were used.They originated from Coniacian shallow-water sequences across a wide range of paleolatitudes,from the Koryak upland(northern Kamchatka,Russian Far East) in the north,to Hokkaido(Japan) in the south.Among Coniacian ammonoids,both migrants from Hokkaido living in high latitudes(Kamchatka) and endemic forms dwelling in middle-low latitudes(Hokkaido) indicate seemingly close optimal growth temperatures.Nevertheless,certain differences in climatic conditions,prevailing during high-latitude coldest seasons,undoubtedly provoked growth cessation in some groups of ammonites.Our isotopic study suggests latitudinal temperature changes of only 0.12 ℃ per degree of latitude for the Northern Hemisphere in Coniacian times,while the average annual tem-perature in North Kamchatka seems about 3.3 ℃ lower than that in Hokkaido. | Yuri D Zakharov Olga P Smyshlyaeva Alexander M Popov Tatiana A Velivetskaya Tamara B Afanasyeva Kazushige Tanabe Yasunari Shigeta Haruyoshi Maeda | 2012 | Journal of Earth Science2012，23，1： | 0 |
| 14 | 尿蛋白质组学是一般人群5年心血管和心脏疾病预后的预测因子显示文摘在以往的横断面研究中,研究人员发现了一种与左心功能障碍相关的尿多维分类因子HF1。该研究旨在探讨HF1是否较传统危险因子对心血管终点事件有更强的预测作用。 | 刘莉 叶鹏 Zhang ZY Lutgarde T Thibault P Gu YM Lotte J Yang WY Liu YP Thomas K Petra Z Yu J Peter V Voigt JU Tatiana K Harald M Jan AS | 2015 | 中华高血压杂志2015，23，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员