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| 1 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 2 | Multivariate analysis of soil heavy metal pollution and landscape pattern in Changhua County in Taiwan 显示文摘 | LIN Y P TENG T P CHANG T K | 2002 | Landscape and Urban Planning2002，62，1： | 1 |
| 3 | Intelligent controlled- wind-turbine emulator and induction-generator system using RBFN显示文摘 | Lin F J Teng L T Shieh P H | 2006 | IEEE Proceedings of Electric Power Applications2006，153，4： | 1 |
| 4 | Analysis of residual stresses and distortion in T-joint filler welds显示文摘 | Teng T L Fung C P Chang P H | 2001 | Intemational Journal of Pressure Vessel and Piping2001，78，： | 1 |
| 5 | Intelligent adaptive backstep- ping control system for Magnetic Levitation Apparatus 显示文摘 | LIN F J TENG L T SHIEH P H | 2007 | IEEE Transactions on Magnetics2007，43，5： | 1 |
| 6 | Experimen- tal and numerical investigations of effect of col- umn length on retardation factor determination: A case study of cesium transport in crushed gran- ite显示文摘 | LI M H WANG T H TENG S P | 2009 | Journal of Hazardous Materials2009，162，1： | 1 |
| 7 | Role of erythropoietin in the brain显示文摘 | Noguchi C T Asavaritikrai P Teng R | 2007 | Crit Rev Oncol Hematol2007，64，2： | 1 |
| 8 | Numerical and experimental investigations on the residual stresses of the butt-welded-joints显示文摘 | CHANG P H TENG T L | 2004 | Computational Materials Science2004，29，4： | 1 |
| 9 | Genetic diversity and disease control in rice 显示文摘 | Zhu Y Y Chen H R Fan J H Wang Y Y Li Y Chert J B Fan J X Yang S S Hu L P Leung H Mew T W Teng P S Wang Z H Mundt C C | 2000 | Nature2000，406，： | 1 |
| 10 | Synergistic inhibition of enterovirus 71replication by interferon and rupintrivir显示文摘 | Hung H C Wang H C Shih S R Teng I F Tseng C P Hsu J T | 2011 | J Infect Dis2011，203，12： | 1 |
| 11 | Muscle apoptosis is induced in pressure-induced deep tissue injury显示文摘 | Siu P M Tam E W Teng B T | 2009 | J Appl Physiol2009，107，4： | 1 |
| 12 | Effect of biofilm on cast iron pipe corrosion in drinking water distribution system: Corrosion scales characterization and microbial community structure investigation显示文摘 | Teng F Guan Y T Zhu W P | 2008 | Corrosion2008，50，10： | 1 |
| 13 | Retrofit Assessment of Window Air Conditioner 显示文摘 | Teng T P Mo H E Lin H | 2012 | Applied Thermal Engi- neering2012，32，1： | 1 |
| 14 | Genetic polymorphism in Gymnodinium galatheanum chloroplast DNA sequences and development of a molecular detection assay显示文摘 | Tengs T Bowers H A Ziman A P | 2001 | Molecular Ecology2001，10，： | 1 |
| 15 | A study of residual stresses in multi-pass girth-butt welded pipes显示文摘 | TENG T L CHANG P H | 1997 | International Journal of Pressure Vessels and Piping1997，74，： | 1 |
| 16 | Genetic poly- morphism in Gymnodinium galatheanum chloroplast DNA sequences and development of a molecular detec- tion assay 显示文摘 | Tengs T Bowers H A Ziman A P | 2001 | Molecular Ecology2001，10，： | 1 |
| 17 | Multivariate analysis of soil heavy metal pollution and landscape pattern in Changhua county in Taiwan 显示文摘 | Lin Y P Teng T P Chang T K | 2002 | Landscape and Urban Planning2002，，62： | 1 |
| 18 | Multivariate analysis of soil heavy metal pollution and landscape pattern in Changhua County in Taiwan显示文摘 | Lin Y P Teng T P Chang T K | 2002 | Landscape and Urban Planning2002，62，： | 1 |
| 19 | Analysis of residual stresses and distortions in T-joint fillet welds 显示文摘 | Teng T L Ftmg C P Chang P H | 2001 | International Journal of Pressure Vessels and Piping2001，78，8： | 1 |
| 20 | Performance assess-ment of heat storage by phase change materials containingMWCNTs and graphite 显示文摘 | Teng T P Cheng C M Cheng C P | 2013 | Applied Thermal Engineer-ing2013，50，1： | 1 |
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