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| 1 | Body-mass index correlates with severity and mortality in acute pancreatitis: A meta-analysis显示文摘BACKGROUND Obesity rates have increased sharply in recent decades. As there is a growing number of cases in which acute pancreatitis(AP) is accompanied by obesity, we found it clinically relevant to investigate how body-mass index(BMI) affects the outcome of the disease.AIM To quantify the association between subgroups of BMI and the severity and mortality of AP.METHODS A meta-analysis was performed using the Preferred Reporting Items for Systematic Review and Meta-Analysis(PRISMA) Protocols. Three databases(PubMed, EMBASE and the Cochrane Library) were searched for articles containing data on BMI, disease severity and mortality rate for AP. Englishlanguage studies from inception to 19 June 2017 were checked against our predetermined eligibility criteria. The included articles reported all AP cases with no restriction on the etiology of the disease. Only studies that classified AP cases according to the Atlanta Criteria were involved in the severity analyses. Odds ratios(OR) and mean differences(MD) were pooled using the random effects model with the DerSimonian-Laird estimation and displayed on forest plots. The meta-analysis was registered in PROSPERO under number CRD42017077890.RESULTS A total of 19 articles were included in our meta-analysis containing data on 9997 patients. As regards severity, a subgroup analysis showed a direct association between AP severity and BMI. BMI < 18.5 had no significant effect on severity;however, BMI > 25 had an almost three-fold increased risk for severe AP in comparison to normal BMI(OR = 2.87, 95%CI: 1.90-4.35, P < 0.001). Importantly,the mean BMI of patients with severe AP is higher than that of the non-severe group(MD = 1.79, 95%CI: 0.89-2.70, P < 0.001). As regards mortality, death rates among AP patients are the highest in the underweight and obese subgroups. A BMI < 18.5 carries an almost two-fold increase in risk of mortality compared to normal BMI(OR = 1.82, 95%CI: 1.32-2.50, P < 0.001). However, the chance of mortality is almost equal in the normal BMI and BMI 25-30 subgroups. A BMI >30 results in a three times higher risk of mortality in comparison to a BMI < 30(OR = 2.89, 95%CI: 1.10-7.36, P = 0.026).CONCLUSION Our findings confirm that a BMI above 25 increases the risk of severe AP, while a BMI > 30 raises the risk of mortality. A BMI < 18.5 carries an almost two times higher risk of mortality in AP. | Dalma Dobszai Péter Mátrai Zoltan Gyongyi Dezso Csupor Judit Bajor Balint Eross Alexandra Mikó Lajos Szakó Agnes Meczker Roland Hágendorn Katalin Márta Andrea Szentesi Péter Hegyi on behalf of the Hungarian Pancreatic Study Group | 2019 | World Journal of Gastroenterology2019，25，6： | 11 |
| 2 | The t(15; 17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus显示文摘 | DE THE H CHOMIENNE C LANOTFE M DEGOS L DEJEAN A | 1990 | Nature1990，347，6293： | 1 |
| 3 | 查看详情显示文摘 | Mlynek A Reich M Giannone L Treutterer W Behler K Blank H Buhler A Cole R Eixenberger H Fischer R Lohs A Lüddecke K Merkel R Neu G Ryter F Zasche D the ASDEX Upgrade Team | | 0，，： | 1 |
| 4 | ASPEN clinical guidelines: nutrition support therapy during adult anticancer treatment and in hematopoietic cell trans- plantation显示文摘 | August D A H uhmann M B the American Society for Paren- teral and Enteral Nutrition (ASPEN) Board of Directors | 2009 | J Parenteral Enteral Nutr2009，33，47： | 1 |
| 5 | Part II:Idealized model of the circulation pat-tern and amplitude in oceanic basins显示文摘 | Stommel H M Arons A B 1960:On the abyssal circulation ofthe World Ocean | 1960 | Deep-Sea Research 6:217-2331960，6，： | 1 |
| 6 | Flow rates East Pacific Rise(21°N) implications for the heat budget and the formation of massive sulfide deposits显示文摘 | Converse D R Holland H D in the axial hot springs of the Edmond J M | 1984 | Earth and Planet Science Letters1984，69，： | 1 |
| 7 | Direct detection of cytomegalovirus in peripheral blood leukocytes-a review of the antigenemia assay and the polymerase chain reaction显示文摘 | van der Ploeg M van der Berg AP | 1992 | Transplantation1992，54，： | 1 |
| 8 | (Ⅰ)Distributions on feasible regions显示文摘 | LINDA M H A statistical approach to the analytic hierarchy process with interval judgements | 1998 | European Journal of Operational Research1998，110，1： | 1 |
| 9 | but the closely linked -629CA polymorphism and a novel promoter variant are independently associ ated with CETP concentration显示文摘 | KLERKX1 A H TANCK M W KASTELEIN J J Haplotype analysis of the CETP gene: not TaqIB | 2003 | Hum Mol Genet2003，12，： | 1 |
| 10 | The t(15, 17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor gene to a novel transcribed locus显示文摘 | de The H Chomienne C Lanotte M | 1990 | Nature1990，347，3： | 1 |
| 11 | An aqueous extract of rubus chingii fruits prOtects primary rat hepatocytes against tertbutyl hydroperOxide indLlced Oxidative stress显示文摘 | Yau M H the C T Liang S M | 2002 | Life Sci2002，72，3： | 1 |
| 12 | The t ( 15; 17) translocation of acute promyelocytic leukemia fuses the retinoic acid receptor alpha gene to a novel transcriptional focus 显示文摘 | de The H Chomienne C lanotte M | 1990 | Nature1990，347，4： | 1 |
| 13 | Fear as A Strategy: Effects and Impact Within The Organization显示文摘 | The Soci- Cambridge Appelbaum S H Bregman M Moroz P | 1998 | Journal of European Industrial Training1998，22，3： | 1 |
| 14 | The t(15; 17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor alpha gene to a novel transcribed locus显示文摘 | De The H Chomianne C Lanotte M | 1991 | Nature1991，347，6293： | 1 |
| 15 | Acid in a Water Solution Reaction显示文摘 | German H Rossetti Enrique Decomposition of Formic Employing the Photo-Fenton D Albizzati Orlando M Alfano | 2002 | IndEng Chem Res2002，，41： | 1 |
| 16 | l~lans 显示文摘 | Shigemori H Tenma M Shimazaki K et aL Three new metulm- lites from the marine yeast Aureobasidiu~ pul | 1998 | J Nat Prod1998，61，5： | 1 |
| 17 | Identification of a retinoic acid responsive element in the retinoic acid receptor beta gene 显示文摘 | DE THE H DEL MAR VR M TIOLLAIS P | 1990 | Nature1990，343，： | 1 |
| 18 | 查看详情显示文摘 | Mlynek A Reich M Giannone L Treutterer W Behler K Blank H Buhler A Cole R Eixenberger H Fischer R Lohs A Lü uddecke K Merkel R Neu G Ryter F Zasche D the ASDEX Upgrade Team | | 0，，： | 1 |
| 19 | The t(15;17) translocation of acute promyelocytic leukaemia fuses the retinoic acid receptor gene to a novel transcribed locus显示文摘 | De The H Chomienne C Lanotte M | 1990 | Nature1990，347，6293： | 1 |
| 20 | Two dimensional discrete fractional Fourier transform显示文摘 | PEI S C THE M H | 1998 | Signal Processing1998，67，： | 1 |
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