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| 1 | Tumor cells educate mesenchymal stromal cells to release chemoprotective and immunomodulatory factors显示文摘Factors released by surrounding cells such as cancer-associated mesenchymal stromal cells(CA-MSCs)are involved in tumor progression and chemoresistance.In this study,we characterize the mechanisms by which naYve mesenchymal stromal cells(MSCs)can acquire a CA-MSCs phenotype.Ovarian tumor cells trigger the transformation of MSCs to CA-MSCs by expressing pro-tumoral genes implicated in the chemoresistance of cancer cells,resulting in the secretion of high levels of CXC chemokine receptors 1 and 2(CXCR1/2)ligands such as chemokine(C-X-C motif)ligand 1(CXCL1),CXCL2,and interleukin 8(IL-8).CXCR1/2 ligands can also inhibit the immune response against ovarian tumor cells.Indeed,through their released factors,CA-MSCs promote the differentiation of monocytes towards M2 macrophages,which favors tumor progression.When CXCR1/2 receptors are inhibited,these CA-MSC-activated macrophages lose their M2 properties and acquire an anti-tumoral phenotype.Both ex vivo and in vivo,we used a CXCR1/2 inhibitor to sensitize ovarian tumor cells to carboplatin and circumvent the pro-tumoral effects of CA-MSCs.Since high concentrations of CXCR1/2 ligands in patients*blood are associated with chemoresistance,CXCR1/2 inhibition could be a potential therapeutic strategy to revert carboplatin resistance. | Augustin Le Naour Melissa Prat Benolt Thibault Renaud Mével Léa Lemaitre Helene Leray Marie-Veronique Joubert Kimberley Coulson Muriel Golzio Lise Lefevre Eliane Mery Alejandra Martinez Gwénael Ferron Jean-Pierre Delord Agnès Coste Bettina Couderc | 2020 | Journal of Molecular Cell Biology2020，12，3： | 3 |
| 2 | Loss of alpha6 integrins in keratinocytes leads to an increase in TGFbeta and AP1 signaling and in expression of differentiation genes显示文摘 | Rodius S Indra G Thibault C | 2007 | J Cell Physiol2007，212，2： | 1 |
| 3 | Control and navigation framewoek for quadrotor helicopters显示文摘 | NAGATY A SAEEDI S THIBAULT C | 2013 | J Intel Robot Syst2013，，5： | 1 |
| 4 | 显示文摘 | LOCK S J THIBAULT P | 1994 | Anal Chem1994，66，： | 1 |
| 5 | TaqMan amplification system with an internal positive control for HCV-RNA quantitation 显示文摘 | Castelain S Descamps V Thibault V | 2004 | J Clin Virol2004，31，： | 1 |
| 6 | StarPU:A unified platform for task scheduling on heterogeneous multi-core architectures显示文摘 | Augonnet C Thibault S Namyst R | 2011 | Concurrency and Computation:Practice and Experience2011，23，2： | 1 |
| 7 | Futile protein folding cycles in the ER are terminated by the unfolded protein O-mannosylationpat-hway显示文摘 | Xu CL Wang S Thibault G | 2013 | 340(6135):978-9812013，340，6135： | 1 |
| 8 | Determination of the degrees of methylation and acetylation of pectins using a C18 column and internal standards显示文摘 | S Levigne M Thomas M.-C Ralet B Quemener J.-F Thibault | 2002 | Food Hydrocolloids2002，，6： | 1 |
| 9 | Engineering the pattern of protein glycosylation modulates the thermostability of a GHII xylanase显示文摘 | Fonseca-Maldonado R Vieira D S Alponti J S Bonneil E Thibault P Ward R J | 2013 | Journal of Biological Chemistry2013，288，25： | 1 |
| 10 | FasL-transfected endothelial cells decrease the proliferative response of allogeneic PBL显示文摘 | Cappellesso S Thibault G Hoarau C | 2002 | Transpl Immunol2002，10，4： | 1 |
| 11 | Protective effect of nifedipine against cytotoxicity and intracellular calcium alterations induced by acetaminophen in rat hepatocyte cultures显示文摘 | Ellouk-Achard S Mawet E Thibault N | 1995 | Drug Chem Toxicol1995，18，23： | 1 |
| 12 | Protective effect of nife dipine against cytotoxicity and intracellular calcium alterations induce by acetaminophen in rat hepatocyte cultures显示文摘 | Mawet E Thibault N | 1995 | Drug Chem Toxicol1995，18，23： | 1 |
| 13 | Experimental transmission of porcine circovirus type 2 ( PCV- Ⅱ ) in weaned pigs: a sequential study 显示文摘 | Magar R Larochelle R Thibault S | 2000 | J Comp Pathol2000，123，： | 1 |
| 14 | Do women notice the impact of childbirth-related trauma on pelvic floor and sexual function?Results of an observation ultrasound study显示文摘 | Thibault Gagnon S Yusuf S Langer S | 2014 | Int Urogynecol J2014，25，10： | 1 |
| 15 | Integrability and linearizability of the Lotka-Volterra System with a saddle point with rational hyperbolicity ratio显示文摘 | Gravel S Thibault P | 2002 | J Differential Equations2002，184，： | 1 |
| 16 | Implementation and characterization of fiber Bragg gratings linearly chirped by a temperature gradient显示文摘 | LAUZON J THIBAULT S MARTIN J | 1994 | Opt Lett1994，19，23： | 1 |
| 17 | Dietary iron overload induced lipid peroxidation are associated with impaired plasma lipid transport and hepatic sterol metabolism in rats显示文摘 | Brunet S Thibault L Delvin E | 1999 | Hepatology1999，29，： | 1 |
| 18 | Long- term insights into the influence of precipitation on community dynamics in desert rodents显示文摘 | Thibault K M Morgan Ernest S K White E P | 2010 | Journal of Mamrnalogy2010，91，4： | 1 |
| 19 | An agency theory perspective on corruption in sport: The case of the international olympic committee显示文摘 | MASON D S THIBAULT L MISENER L | 2006 | J Sport Manage2006，20，1： | 1 |
| 20 | Futile protein folding cycles in the ER are terminated by the unfolded protein O- mannosylation pathway 显示文摘 | Xu C Wang S Thibault G | 2013 | Science2013，340，6135： | 1 |
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