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| 1 | Current status and perspectives of immune-based therapiesfor hepatocellular carcinoma显示文摘Hepatocellular carcinoma(HCC)is a frequent cancer with a high mortality.For early stage cancer there are potentially curative treatments including local ablation,resection and liver transplantation.However,for more advanced stage disease,there is no optimal treatment available.Even in the case of a'curative'treatment,recurrence or development of a new cancer in the precancerous liver is common.Thus,there is an urgent need for novel and effective(adjuvant)therapies to treat HCC and to prevent recurrence after local treatment in patients with HCC.The unique immune response in the liver favors tolerance,which remains a genuine challenge for conventional immunotherapy in patients with HCC.However,even in this'immunotolerant'organ,spontaneous immune responses against tumor antigens have been detected,although they are insufficient to achieve significant tumor death.Local ablation therapy leads to immunogenic tumor cell death by inducing the release of massive amounts of antigens,which enhances spontaneous immune response.New immune therapies such as dendritic cell vaccination and immune checkpoint inhibition are under investigation.Immunotherapy for cancer has made huge progress in the last few years and clinical trials examining the use of immunotherapy to treat hepatocellular carcinoma have shown some success.In this review,we discuss the current status of and offer some perspectives on immunotherapy for hepatocellular carcinoma,which could change disease progression in the near future. | Maridi Aerts DaphnéBenteyn Hans Van Vlierberghe Kris Thielemans Hendrik Reynaert | 2016 | World Journal of Gastroenterology2016，22，1： | 24 |
| 2 | lnterection of the growthhonnone-re- leasing peptides ghrelin and growth hormone-releasingpeptide 6 with the motilin receptor in the rabbit gastric antrum显示文摘 | Depoortere I Thijs T Thielemans L | 2003 | JPharmacol Exp Ther2003，305，2： | 1 |
| 3 | Murine dendritic eells pulsed in vitro with tmnor antigen induce tumor resistance in vivo显示文摘 | Flamand V Sornasse T Thielemans K | 1994 | Eur J hnnmnol1994，24，3： | 1 |
| 4 | Cellulose nanowhisker aerogels显示文摘 | Heath L Thielemans W | 2010 | Green Chemistry2010，12，： | 1 |
| 5 | Surface functionalization of cellulose fibres and their incorporation in renewable polymeric matrices 显示文摘 | LY B THIELEMANS W DUFRESNE A | 2008 | Composites Science and Technology2008，68，： | 1 |
| 6 | Murine dendritic cells pulsed in vitro with tumor antigen induce tumor resistance in vivo显示文摘 | Flamand V Sornasse T Thielemans K | 1994 | Eur J Immunol1994，24，3： | 1 |
| 7 | Lentiviral vectors for antitumor immunotherapy显示文摘 | Breckpot K Emeagi PU Thielemans K | 2008 | Curr Gene Ther2008，8，6： | 1 |
| 8 | Sisal cellulose whiskers reinforced polyvinyl acetate nanocomposites显示文摘 | DE RODRIGUEZ N L G THIELEMANS W DUFRESNE A | 2006 | Cellulose2006，13，3： | 1 |
| 9 | Mechanical properties of nanocomposites from sorbitol plasticized starch and tunicinwhiskers显示文摘 | Mathew A P Thielemans W Dufresne A | 2008 | Journal of Applied Polymer Science2008，109，6： | 1 |
| 10 | Engineering Dendritic Cells to Enhance Cancer Immunotherapy显示文摘 | Boudreau JE Bonehill A Thielemans K | 2011 | Mol Ther2011，19，5： | 1 |
| 11 | Identification of a melanoma-associated chondroitin sulfate proteoglycan (MCSP) peptide recognized by CD4+ T lymphocytes on human melanoma cells显示文摘 | ERFURT C S HEIRMAN C THIELEMANS K | 2004 | Cancer Cell Int2004，4，1： | 1 |
| 12 | Interection of the growth hormone-releasing peptides ghrelin and growth hormone-releasing peptide 6 with the motilin receptor in the rabbit gastric antrum显示文摘 | Depoortere I Thijs T Thielemans L | 2003 | J Pharmacol Exp Ther2003，305，2： | 1 |
| 13 | The Role of SMAC Mimeties in Regulation of Tumor Cell Death and Immunity显示文摘 | Emeagi PU Thielemans K Breckpot K | 2012 | Oncoimmunology2012，1，6： | 1 |
| 14 | A survey of approaches for direct parametric image reconstruction in emission tomography 显示文摘 | Tsoumpas C Turkheimer F E Thielemans K | 2008 | Medical Physics2008，35，9： | 1 |
| 15 | Interaction of the growth hormone-releasing peptides ghrelin and growth hormone-releasing pepfide-6 with the motilin receptor in the rabbit gastric antrum显示文摘 | Depoortere I Thijs T Thielemans L | | 0，，2： | 1 |
| 16 | Cellulose nanocrystals grafted with polystyrene chains through surface-initiated atom transfer radical polymerization(SI-ATRP)显示文摘 | MORANDI G HEATH L THIELEMANS W | 2009 | Langmuir2009，25，14： | 1 |
| 17 | Surface functionalization of cellulose fibres and their incorporation in rene-wable polymeric matrices显示文摘 | Ly B Thielemans W Dufresne A | 2008 | Comps Sci Techn2008，68，： | 1 |
| 18 | Cellulose nanocrystals grafted with polystyrene chains through surface-initiated atom transfer radical polymerization(SI-ATRP)显示文摘 | Morandi G Heath L Thielemans W | 2009 | Langmuir2009，25，14： | 1 |
| 19 | Cellulose nanocrystals grafted with polystyrene chains through surface-initiated atom transfer radical polymerization (SI-ATRP) 显示文摘 | MORANDI G HEATH L THIELEMANS W | 2009 | Langmuir2009，25，14： | 1 |
| 20 | Surface functionalization of cellulose fibres and their incorporation in renewable polymeric matrices显示文摘 | B. Ly W. Thielemans A. Dufresne D. Chaussy M.N. Belgacem | 2008 | Composites Science and Technology2008，，15： | 1 |
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