|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | DPM dissipation experiment at MST's experimental mine and comparison with CFD simulation显示文摘 | ZHENG Yi LAN Hai THIRUVENGADAM Magesh TIEN Jerry C | 2011 | Journal of Coal Science & Engineering(China)2011，17，3： | 9 |
| 2 | Effect of auxiliary ventilations on diesel particulate matter dispersion inside a dead-end entry显示文摘Diesel particulate matter(DPM) is considered carcinogenic after prolonged exposure. This paper used computational fluid dynamics(CFD) method to study the effect of four auxiliary ventilation systems on DPM distribution in a dead-end entry with loading operation. The auxiliary ventilation systems considered include: blower fan and tubing; exhaust fan and tubing, jet fan, and push–pull system. A species transport model with buoyancy effect was used to examine the DPM dispersion pattern with unsteady state analysis. During the 200 s of the loading operation, high DPM levels were identified in the face and dead-end entry regions. This study can be used for mining engineer as guidance to design and setup of local ventilation. It can also be used for selection of DPM control strategies and DPM annual training for underground miners. | Zheng Yi Thiruvengadam Magesh Lan Hai Tien C.Jerry | 2015 | International Journal of Mining Science and Technology2015，25，6： | 7 |
| 3 | DPM simulation in an underground entry: Comparison between particle and species models显示文摘The diesel particulate matter(DPM) emission from diesel powered equipment in underground mines can cause health hazards including cancer to the miners. The understanding of the DPM propagation pattern under realistic mining condition is required for selecting proper DPM control strategies and to improve working practices in underground mines. In this paper, three dimensional simulations of DPM emission from the exhaust tail pipe of a load-haul-dump(LHD) vehicle and its subsequent distribution inside an isolated zone in the typical underground mine are carried out using two different solution models available in Ansys Fluent. The incoming fresh air into the isolated zone is treated as a continuous phase and DPM is treated either as a continuous phase(gas) or as a secondary discrete phase(particle). Species transport model is used when DPM is treated as gas and discrete phase model is used when DPM is assumed to behave like a particle. The distributions of DPM concentration inside the isolated zone obtained from each method are presented and compared. From the comparison results, an accurate and economical solution technique for DPM evaluation can be selected. | Thiruvengadam Magesh Zheng Yi Tien Jerry C. | 2016 | International Journal of Mining Science and Technology2016，26，3： | 7 |
| 4 | Simulation of DPM distribution in a long single entry with buoyancy effect显示文摘Diesel particulate matter(DPM) is considered carcinogenic after prolonged exposure. With more dieselpowered equipment used in underground mines, miners' exposure to DPM has become an increasing concern. This paper used computational fluid dynamics(CFD) method to study DPM distribution based on an experiment conducted by the Diesel Emissions Evaluation Program(DEEP) in Canada. Twenty-four cases were simulated where the emissions from both truck and load-haul-dumps(LHDs) were examined.Each vehicle was placed in two stream wise locations, and the vehicles were oriented either facing or with the rear end toward the main fresh airflow. A species transport model with buoyancy effect was then used to examine the DPM dispersion pattern. High DPM regions were identified downstream,around, and even upstream of diesel engines. This can provide guidelines for good working practices and selection of diesel emission reduction technologies underground. | Zheng Yi Thiruvengadam Magesh Lan Hai Tien C.Jerry | 2015 | International Journal of Mining Science and Technology2015，25，1： | 6 |
| 5 | Hesperetin conjugated PEGylated gold nanoparticles exploring the potential role in anti-inflammation and anti-proliferation during diethylnitrosamine-induced hepatocarcinogenesis in rats显示文摘Liver cancer is the fifth most common cancer and one of the leading causes of death in the world, and second most common cause of death in men. Natural products emerge as the most enduring approaches in the development of anticancer targeting drug. Hesperetin(HP), one of the abundant flavonoids found naturally in citrus fruits, has received considerable attention in anti-cancer promotion and progression. The present study was conducted to decipher the role of 0.5 ml hesperetin conjugated gold nanoparticles(Au-m PEG(5000)-S-HP NPs) during diethylnitrosamine(DEN)-induced hepatocarcinogenesis in male Wistar albino rats and shows the better antioxidant that possesses anti-inflammatory,anti-proliferation and anticarcinogenic properties and may modulate signaling pathways.The confirmation of polymer functionalized gold nanoparticles and drug loaded polymer gold nanoparticles were characterized by HR-TEM with EDAX, and DLS with Zeta potential techniques. The drug encapsulation efficiency and release properties were carried out in PBS at pH 7.4 for Au-mPEG(5000)-S-HP and compared with the control pure hesperetin(HP).Here, we review the role of mast cell counts, tumor necrosis factor alpha(TNF-α), transcription factor nuclear factor-κB(NF-κB), levels of glycoconjugates, proliferating cell nuclear antigen(PCNA) and argyrophilic nucleolar organizing regions, are the master regulator of inflammation and proliferation, in the development of hepatocellular injury, liver fibrosis and HCC. DEN-administered animals showed increased mast cell counts, tumor necrosis factor alpha, transcription factor nuclear factor-κB, glycoconjugates, proliferating cell nuclear antigen, and argyrophilic nucleolar organizing regions. Whereas Au-mPEG(5000)-S-HP NPs supplementation considerably suppressed all the above abnormalities. These results suggest that the Au-m PEG(5000)-S-HP NPs exhibited the better potential anticancer activity by inhibiting cell inflammation and proliferation in DEN-induced hepatocellular carcinogenesis. | Gokuladhas Krishnan Jayakumar Subramaniyan Pramila Chengalvarayan Subramani Barath Muralidharan Devaki Thiruvengadam | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，5： | 4 |
| 6 | Fully covered metal biliary stents: A review of the literature显示文摘Fully covered self-expandable metal stents(FCSEMS)represent the latest advancement of metal biliary stents used to endoscopically treat a variety of obstructive biliary pathology.A large stent diameter and synthetic covering over the tubular mesh prolong stent patency and reduce risk for tissue hyperplasia and tumor ingrowth.Additionally,FCSEMS can be easily removed.All these features address issues faced by plastic and uncovered metal stents.The purpose of this paper is to comprehensively review the application of FCSEMS in benign and malignant biliary strictures,biliary leak,and post-sphincterotomy bleeding. | Robert Lam Thiruvengadam Muniraj | 2021 | World Journal of Gastroenterology2021，27，38： | 4 |
| 7 | Lycopene stabilizes lipoprotein levels during D-galactosamine/lipopolysaccharide induced hepatitis in experimental rats显示文摘Objective:To investigate the effect of lycopene on lipoprotein metabolism during D-galactosamine/lipopolysacchoride(D-Gal/LPS)induced hepatitis in experimentul rats.Methods:The efficacy of lycopene was validated during D-Gal/LPS induced hepatitis by analyzing the activity of lipid metabolizing enzymes such as lipoprotein lipase(LPL),lecithincholesterol acyl transferase(LCAT)and hepatic triglyceride lipase(HTCL).Lipo protein analyses were done by the estimation of very low density lipoprotein cholesterol(VLDL),low density lipoprotein cholesterol(LDL)and high density lipoprotein cholesterol(HDL).Remits:The toxic insult of D-galactosamine/lipopolysaccharide(D-Gal/LPS)in experimental group of animals reduces the normal values of lipid metabolizing enzymes due to liver injury.The significant drop in the levels of HDL and concomitant increase in the values of VLDL and LDL were observed.The pretreatment of lycopene restore these altered values to near normal level in experimental group of animals.Conclusions:In the light of results,it can be concluded that administration lycopene stabilizes the lipoprotein levels by regulating the lipid metabolizing enzymes through its antioxidant defense and helps to maintain the normal lipid metabolism during toxic injury in liver. | Sheik Abdulazeez Sheriff Thiruvengadam Devaki | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，12： | 4 |
| 8 | Design of push-pull system to control diesel particular matter inside a dead-end entry显示文摘 | Yi Zheng Magesh Thiruvengadam Hai Lan Jerry C. Tien | 2015 | International Journal of Coal Science & Technology2015，2，3： | 3 |
| 9 | Effect of single dead end entry inclination on DPM plume dispersion显示文摘Diesel particulate matter(DPM) is a by-product from operating diesel engines. Since diesel powers are one of the major sources of energy for mobile underground mining equipment, the adverse health effects of DPM are of a great concern. This paper used computational fluid dynamics(CFD) method to study the effect of entry inclination on DPM plume distribution in a dead end entry. An upward mining face and a downward mining face were built with a truck and a loader in loading operation close to the face area. A species transport model with incorporated buoyancy effect was used to examine the DPM dispersion pattern for the above steady-state scenarios. High DPM and temperature regions were identified for the two different faces. The model was used to assess the role of auxiliary ventilation in reducing DPM exposures of underground miners working in those entries. In this study, it is suggested to provide local ventilation at least three times of the diesel exhaust rate to be able to lower the average DPM level for the mining upward face. The requirement for local ventilation is much less for the mining downward face. This can provide guidelines for good working practices and selection of diesel emission reduction technologies underground. | Zheng Yi Lan Hai Thiruvengadam Magesh Tien Jerry C. Li Ying | 2017 | International Journal of Mining Science and Technology2017，27，3： | 3 |
| 10 | Carvacrol Promotes Cell Cycle Arrest and Apoptosis through PI3K/AKT Signaling Pathway in MCF-7 Breast Cancer Cells显示文摘Objective:To examine the role of carvacrol in modulating PI3 K/AKT signaling involved in human breast cancer pathogenesis using in vitro experimental model MCF-7 cells.Methods:MTT and lactate dehydrogenase assays were performed with cells treated with different doses of carvacrol(0–250μmol/L)at different time points(24 and 48 h).The nuclear morphology was assessed in MCF-7 cells with propidium iodide(PI)and acridine orange/ethidium bromide(AO/EB)staining and analyzed by fluorescence microscopy.Events like cell cycle arrest and apoptosis were observed by flow cytometric analysis and expressions of p-Rb,cyclin D1,cyclin-dependent kinase 4(CDK4),CDK6,Bax,Bcl-2,PI3 K/p-AKT were analyzed by immunoblot.Results:Carvacrol significantly reduced cell viability with the half maximal inhibitory concentration value of 200μmol/L at 24 and 48 h(P<0.05).importantly,there was a significant increase in the accumulation of the G0/G1 phase upon treatment with carvacrol in MCF-7 cells(P<0.05 or P<0.01).A remarkable decrease in protein expressions of p-Rb,cyclin D1,CDK4 and CDK6 denoted cell cycle arrest(P<0.05 or P<0.01).In addition,carvacrol treatment significantly inhibited PI3 K/p-AKT protein expressions leading to induction of apoptosis mediated by decreased Bcl2 and increased Bax protein expressions.Further,Annexin V/PI staining by FACS analysis,dual staining by AO/EB and PI staining studies suggested induction of apoptosis by carvacrol through PI3 K/Akt signaling pathway in MCF-7 cells.Conclusion:Carvacrol significantly inhibited the breast cancer MCF-7 cell proliferation and induced apoptosis via suppressing PI3/AKT signaling pathway. | Ashok Mari Gopikrishnan Mani Sirpu Natesh Nagabhishek Gopaiakrishnan Balaraman Nirmala Subramanian Fathima Bushra Mirza Jagan Sundaram Devaki Thiruvengadam | 2021 | Chinese Journal of Integrative Medicine2021，27，9： | 3 |
| 11 | Resection of pancreatic cystic neoplasms in recurrent acute pancreatitis prevents recurrent pancreatitis but does not identify more malignancies显示文摘BACKGROUND Recurrent acute pancreatitis(RAP)may be a presenting feature of and an indication for resection of pancreatic cysts,including intra-ductal papillary mucinous neoplasm(IPMN).Few data are available regarding the prevalence of malignancy and post-operative RAP in this population.AIM To study the role of resection to help prevent RAP and analyze if presentation as RAP would be a predictor for malignancy.METHODS This retrospective study assessed 172 patients who underwent surgical resection of pancreatic cystic neoplasms at a university hospital between 2002 and 2016.The prevalence of preoperative high-risk cyst features,and of neoplasia was compared between patients with and without RAP.To identify the cause of pancreatitis,all the patients had a detailed history of alcohol,smoking,medications obtained,and had cross-sectional imaging(contrast-enhanced computed tomography/magnetic resonance imaging)and endoscopic ultrasound to look for gallstone etiology and other structural causes for pancreatitis.The incidence of RAP post-resection was the primary outcome.RESULTS IPMN accounted for 101 cases(58.7%){[branch duct(BD)59(34.3%),main duct(MD)42](24.4%)}.Twenty-nine(16.9%)presented with RAP(mean 2.2 episodes):15 had BD-IPMN,8 MD-IPMN,5 mucinous cystic neoplasm and 1 serous cystic neoplasm.Malignancy was similar among those with vs without RAP for all patients[6/29(20.7%)vs 24/143(16.8%)]and IPMN patients[6/23(26.1%)vs 23/78(29.5%)],although tended to be higher with RAP in BD-IPMN,[5/15(33.3%)vs 3/44(6.8%),P=0.04].At mean follow-up of 7.2 years,1(3.4%)RAP patient had post-resection RAP.The mean episodes of acute pancreatitis before vs after surgery were 3.4 vs 0.02(P<0.0001).CONCLUSION Malignancy was not increased in patients with pancreatic cystic neoplasms who have RAP compared to those without RAP.In addition,specific cyst characteristics were not clearly associated with RAP.The incidence of RAP was markedly decreased in almost all patients following cyst resection. | Thiruvengadam Muniraj Harry R Aslanian Loren Laine Priya A Jamidar James F Farrell Kisha A Mitchell Ronald R Salem | 2021 | World Journal of Gastroenterology2021，27，15： | 3 |
| 12 | 他克莫司和吲哚美辛可安全有效降低肝移植患者经内镜逆行胰胆管造影术后胰腺炎发生率显示文摘肝移植术后胆管并发症的发生率高达25%,且通常需要经内镜逆行胰胆管造影(ERCP)介入治疗。胰腺炎(PEP)是ERCP术后最常见的不良事件。他克莫司(一种钙调神经磷酸酶抑制剂)和直肠吲哚美辛均有报告可降低ERCP术后PEP的发生风险。来自美国加州大学旧金山分校等机构的研究者进行了一项回顾性队列分析,探讨了肝移植患者接受ERCP诊治的PEP发生率和他克莫司和(或)吲哚美辛降低PEP风险的有效性。 | 李家速 方军 THIRUVENGADAM NR FORDE KA CHANDRASEKHARA V | 2020 | 临床肝胆病杂志2020，36，7： | 2 |
| 13 | Establishing the role of detoxifying enzymes in field-evolved resistance to various insecticides in the brown planthopper (Nilaparvata lugens) in South India显示文摘棕色的 planthopper (BPH ) , Nilaparvata lugens (Stål ) ,是在整个亚洲的米饭的主要害虫之一。为压制 N 的杀虫药剂的广泛的使用。lugens 导致了在这域里导致经常的控制失败的杀虫药剂抵抗的开发。现在的学习的目的是在 N 的领域人口评估抵抗。从种南方印度的状态到各种各样的杀虫药剂的主要米饭的 lugens。我们也决定了除去的活动酶(esterases [EST ] ,谷胱甘肽 S-transferases [GST ] ,并且混合功能 oxidases [MFO ]) 。抵抗的中等层次在地人口被检测到 acephate , thiamethoxam 和 buprofezin (抵抗因素 1.05-20.92 褶层, 4.52-14.99 褶层,和 1.00-18.09 褶层,分别地)作为与易受影响的紧张相比当有到 imidacloprid (抵抗因素 1.23-6.70 褶层)和完全的敏感的抵抗的底层到 etofenoprox (抵抗因素 1.05-1.66 褶层)时。当为 GST 和 MFO 比率分别地从 1.29 ~ 3.41 和 1.03 ~ 1.76 变化了时,在领域人口的 EST 活动比易受影响的紧张高 1.06 ~ 3.09 倍。EST 活动被发现被相关到 acephate 抵抗(r = 0.999, P ≥ 0.001 ) 。organophosphate, neonicotinoid,和这块地里的昆虫生长管理者(IGR ) 的高选择压力是可能的在 BPH 为抵抗正在作出贡献到多重杀虫药剂,导致控制失败。获得的结果将对为对 BPH 的有效杀虫药剂的使用的 IPM 建议有益。 | Vijayakumar Maheshwari Malathi Sushil K. Jalali Dandinashivara K. Sidde Gowda Muthugounder Mohan Thiruvengadam Venkatesan | 2017 | Insect Science2017，24，1： | 2 |
| 14 | Inhibition of the Hedgehog Pathway Targets the Tumor-Associated Stroma in Pancreatic Cancer显示文摘 | Rosa F. Hwang Todd T. Moore Maureen Mertens Hattersley Meghan Scarpitti Bin Yang Erik Devereaux Vijaya Ramachandran Thiruvengadam Arumugam Baoan Ji Craig D. Logsdon Jeffrey L. Brown Robert Godin | 2012 | Molecular Cancer Research2012，，9： | 2 |
| 15 | Project scheduling and monitoring: current research status显示文摘 | Ahuja V Thiruvengadam V | 2004 | Construction and Innovation:Information Process Management2004，4，1： | 1 |
| 16 | Fast threshold se- lection algorithm for segmentation of synthetic aperture radar image显示文摘 | RANJANI J J THIRUVENGADAM S J | 2012 | Radar Sonar & Navigation lET2012，6，8： | 1 |
| 17 | Ectopic expression of two MADS box genes from orchid (Oncidium Gower Ramsey) and lily (Lilium longiflo- rum) alters flower transition and formation in Eustoma grandiflorum显示文摘 | THIRUVENGADAM M YANG C | 2009 | Plant Cell Rep2009，，： | 1 |
| 18 | Generalized A- nalysis of Gasifier Performance using Equilibrium Modeling显示文摘 | Anapagaddi R Thiruvengadam R Subramaniam P | 2011 | In- dustrial & Engineering Chemistry Research2011，7，： | 1 |
| 19 | Overexpression of On- cidium MADS box (OMADS1) gene promotes early flowering in transgenic orchid (Oncidium Gower Ramsey) 显示文摘 | THIRUVENGADAM M CHUNG I YANG C | 2012 | Acta Physiol Plant2012，34，4： | 1 |
| 20 | Investigation on pre-zygotic barriers in the interspecifie crosses involving Gossypium barbadense and four diploid wild species显示文摘 | Ram S G Thiruvengadam V Ramakrishnan S H | 2007 | Euphytica2007，159，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员