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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Factors associated with incomplete small bowel capsule endoscopy studies显示文摘AIM:To identify patient risk factors associated with incomplete small bowel capsule endoscopy(CE) studies.METHODS:Data from all CE procedures performed at St.Paul's Hospital in Vancouver,British Columbia,Canada,between December 2001 and June 2008 were collected and analyzed on a retrospective basis.Data collection for complete and incomplete CE study groups included patient demographics as well as a number of potential risk factors for incomplete CE including indication for the procedure,hospitalization,diabetes mellitus with or without end organ damage,limitations in mobility,renal insufficiency,past history of bowel obstruction,abdominal surgery,abdominal radiation therapy and opiate use.Risk factors were analyzed using a univariable and multivariable logistic regression model.RESULTS:From a total of 535 CE procedures performed,158 were incomplete(29.5%).The univariable analysis showed that CE procedures performed for overt gastrointestinal bleeding(P = 0.002),and for patients with a prior history of abdominal surgery(P = 0.023) or bowel obstruction(P = 0.023) were significantly associated with incomplete CE studies.Patients on opiate medications(P = 0.094) as well as hospitalized patients(P = 0.054) were not statistically significant,but did show a trend towards incomplete CE.The multivariable analysis showed that independent risk factors for an incomplete CE procedure include prior history of bowel obstruction [odds ratios(OR) 2.77,P = 0.02,95% confidence intervals(CI):1.17-6.56] and procedures performed for gastrointestinal bleeding(Occult OR 2.04,P = 0.037,95% CI:1.04-4.02 and Overt OR 2.69,P = 0.002,95% CI:1.44-5.05).Patients with a prior history of abdominal surgery(OR 1.46,P = 0.068,95% CI:0.97-2.19),those taking opiate medications(OR 1.54,P = 0.15,95% CI:0.86-2.76) and hospitalized patients(OR 1.82,P = 0.124,95% CI:0.85-3.93) showed a trend towards statistical significance.CONCLUSION:We have identified a number of risk factors for incomplete CE procedures that can be used to risk-stratify patients and guide interventions to improve completion rates. | Mitchell M Lee Andrew Jacques Eric Lam Ricky Kwok Pardis Lakzadeh Ajit Sandhar Brandon Segal Sigrid Svarta Joanna Law Robert Enns | 2010 | World Journal of Gastroenterology2010，16，42： | 10 |
| 3 | Biliary brush cytology:Factors associated with positive yields on biliary brush cytology显示文摘AIM: To evaluate the yield of brushing biliary strictures and the factors associated with a positive result in biliary strictures. METHODS: Data on all consecutive patients (01/02 -10/05) who were identified to have a biliary stricture and who underwent biliary brush cytology were collected. The yield of positive biliary brush cytology was evaluated and compared to results with the gold standard for diagnosis (defi ned as either defi nitive surgical histology or clinical course). Additionally,associated factors of positive results including stricture location,gender,age,mass size,length of stricture,and dilatation prior to brushing cytology were assessed. RESULTS: From 199 patients who had brushing cytology samples (10 patients were excluded due to lack of gold standard diagnosis),77 patients had positive brushing cytology (yield 41%). Variables associated with positive cytology brushing on initial endoscopic retrograde cholangiography were age 1.02 (1.00-1.05),mass size > 1 cm 2.22 (1.01-4.89) and length of stricture > 1 cm 3.49 (1.18-10.2). The sensitivity of biliary brushing was 61%,its specifi city 98%,the positive predictive value reached 99%,and the negative predictive value was 57%. CONCLUSION: Our results revealed a 41% positive yield from brushing cytology. The sensitivity of biliary brushing cytology in our center was 61% and the specif icity was 98%. Predictors of positive yield include older age,mass size > 1 cm,and stricture length of > 1 cm. | Nasim Mahmoudi Robert Enns Jack Amar Jaber AlAli Eric Lam Jennifer Telford | 2008 | World Journal of Gastroenterology2008，14，4： | 10 |
| 4 | Fecal Microbiome and Volatile Organic Compound Metabolome in Obese Humans With Nonalcoholic Fatty Liver Disease显示文摘 | Maitreyi Raman Iftikhar Ahmed Patrick M. Gillevet Chris S. Probert Norman M. Ratcliffe Steve Smith Rosemary Greenwood Masoumeh Sikaroodi Victor Lam Pam Crotty Jennifer Bailey Robert P. Myers Kevin P. Rioux | 2013 | Clinical Gastroenterology and Hepatology2013，，7： | 5 |
| 5 | Clinicopathological significance of synchronous carcinoma in colorectal cancer显示文摘 | Alfred King-Yin Lam Robert Carmichael Petra Gertraud Buettner Vinod Gopalan Yik-Hong Ho Simon Siu | 2011 | The American Journal of Surgery2011，，1： | 4 |
| 6 | Fully covered metal biliary stents: A review of the literature显示文摘Fully covered self-expandable metal stents(FCSEMS)represent the latest advancement of metal biliary stents used to endoscopically treat a variety of obstructive biliary pathology.A large stent diameter and synthetic covering over the tubular mesh prolong stent patency and reduce risk for tissue hyperplasia and tumor ingrowth.Additionally,FCSEMS can be easily removed.All these features address issues faced by plastic and uncovered metal stents.The purpose of this paper is to comprehensively review the application of FCSEMS in benign and malignant biliary strictures,biliary leak,and post-sphincterotomy bleeding. | Robert Lam Thiruvengadam Muniraj | 2021 | World Journal of Gastroenterology2021，27，38： | 4 |
| 7 | Double-blind randomized sham controlled trial of intraperitoneal bupivacaine during emergency laparoscopic cholecystectomy显示文摘BACKGROUND: Intraperitoneal local anesthesia (IPLA) during elective laparoscopic cholecystectomy (el-LC) decreases post-operative pain. None of the studies have explored the efficacy of IPLA at emergency laparoscopic cholecystectomy (em-LC). A longer operative duration, the greater frequency of washing, and the inflammation associated with cholecystitis or pancreatitis are a few reasons why it cannot be assumed that a benefit in pain scores will be seen in em-LC with IPLA. This study was undertaken to assess the efficacy of IPLA in patients undergoing em-LC. METHODS: Double-blind randomized sham controlled trial was conducted of 41 consecutive subjects undergoing em-LC. IPLA was delivered by a combination of injection to the diaphragmatic and topical wash over the liver and gallbladder with bupivacaine or saline. The primary outcome was visual analogue scale pain scores until discharge. Secondary outcomes included pain scores in theatre recovery and analgesic consumption. RESULTS: One patient had a procedure converted to open and was excluded. There was no significant difference in pain scores in the ward or theatre recovery. Analgesic use, respiratory rate, oxygen saturation, duration to ambulation, eating, satisfaction scores, and time to discharge were comparable between the two groups. CONCLUSIONS: IPLA during em-LC does not influence postoperative pain. Other modalities of analgesia should be explored for decreasing the interval between diagnosis of acute admission and em-LC. | Keith J Roberts Jeff Gilmour Ruplay Pande James Hodson For Tai Lam Saboor Khan | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，3： | 3 |
| 8 | Health-related quality of life, work productivity, and health care resource utilization of subjects with irritable bowel syndrome: Baseline results from logic (longitudinal outcomes study of gastrointestinal symptoms in Canada), a naturalistic study显示文摘 | Pierre Paré James Gray Sy Lam Robert Balshaw Shideh Khorasheh Martin Barbeau Suzanne Kelly Christopher R. McBurney | 2006 | Clinical Therapeutics2006，，10： | 2 |
| 9 | miR-126 in human cancers: Clinical roles and current perspectives显示文摘 | Faeza Ebrahimi Vinod Gopalan Robert Anthony Smith Alfred King-Yin Lam | 2013 | Experimental and Molecular Pathology2013，，： | 2 |
| 10 | Diagnostic Yield of Spiral Enteroscopy When Performed for the Evaluation of Abnormal Capsule Endoscopy Findings显示文摘 | Jonathan M. Buscaglia Robert Richards Mark N. Wilkinson Joel R. Judah Yvette Lam Satish Nagula Peter V. Draganov | 2011 | Journal of Clinical Gastroenterology2011，，4： | 2 |
| 11 | SAFETY AND EFFICACY OF PARTIAL NEPHRECTOMY FOR ALL T1 TUMORS BASED ON AN INTERNATIONAL MULTICENTER EXPERIENCE显示文摘 | JEAN-JACQUES PATARD OLEG SHVARTS JOHN S. LAM ALLAN J. PANTUCK HYUNG L. KIM VINCENZO FICARRA LUCA CINDOLO KEN-RYU HAN ALEXANDRE DE LA TAILLE JACQUES TOSTAIN WALTER ARTIBANI CLAUDE C. ABBOU BERNARD LOBEL DOMINIQUE K. CHOPIN ROBERT A. FIGLIN PETER F.A. MULDE | 2004 | The Journal of Urology2004，，6： | 2 |
| 12 | Identification of Adropin as a Secreted Factor Linking Dietary Macronutrient Intake with Energy Homeostasis and Lipid Metabolism显示文摘 | K. Ganesh Kumar James L. Trevaskis Daniel D. Lam Gregory M. Sutton Robert A. Koza Vladimir N. Chouljenko Konstantin G. Kousoulas Pamela M. Rogers Robert A. Kesterson Marie Thearle Anthony W. Ferrante Randall L. Mynatt Thomas P. Burris Jesse Z. Dong Heathe | 2008 | Cell Metabolism2008，，： | 2 |
| 13 | Metachronous carcinomas in colorectum and its clinicopathological significance显示文摘 | Alfred Lam Vinod Gopalan Robert Carmichael Petra Buettner Melissa Leung Robert Smith Cu-Tai Lu Yik-Hong Ho Simon Siu | 2012 | International Journal of Colorectal Disease2012，，10： | 1 |
| 14 | Comparative Study of Central Corneal Thickness Measurement with Slit-Lamp Optical Coherence Tomography and Visante Optical Coherence Tomography显示文摘 | Haitao Li Christopher Kai Shun Leung Lee Wong Carol Yim Lui Cheung Chi Pui Pang Robert Neal Weinreb Dennis Shun Chiu Lam | 2008 | Ophthalmology2008，，5： | 1 |
| 15 | Role of molecular markers in the diagnosis and therapy of renal cell carcinoma显示文摘 | John S. Lam John T. Leppert Robert A. Figlin Arie S. Belldegrun | 2005 | Urology2005，，5： | 1 |
| 16 | Primary 23-gauge transconjunctival sutureless vitrectomy for rheg- matogenous retinal detachment显示文摘 | Chi-Wai Tsang Benson Tze-On Cheung Robert Fung Lam | 2008 | Retina2008，28，8： | 1 |
| 17 | Clinical impacts of mammalian target of rapamycin expression in human colorectal cancers显示文摘 | Naif AlQurashi Vinod Gopalan Robert A. Smith Alfred King Y. Lam | 2013 | Human Pathology2013，，： | 1 |
| 18 | Co-regulatory potential of vascular endothelial growth factor–A and vascular endothelial growth factor–C in thyroid carcinoma显示文摘 | Ali Salajegheh Sahar Pakneshan Atiqur Rahman Elliot Dolan-Evans Sheldon Zhang Esther Kwong Vinod Gopalan Chung-Yau Lo Robert Anthony Smith Alfred King-Yin Lam | 2013 | Human Pathology2013，，： | 1 |
| 19 | Detection and Localization of Intraepithelial Neoplasia and Invasive Carcinoma Using Fluorescence-Reflectance Bronchoscopy: An International, Multicenter Clinical Trial显示文摘 | Eric Edell Stephen Lam Harvey Pass York E. Miller Thomas Sutedja Timothy Kennedy Gregory Loewen Robert L. Keith | 2009 | Journal of Thoracic Oncology2009，，1： | 1 |
| 20 | Serum testosterone, dihydrotestosterone and estradiol concentrations in older men self‐reporting very good health: the healthy man study显示文摘 | Gideon Sartorius Sasa Spasevska Amanda Idan Leo Turner Elise Forbes Anna Zamojska Carolyn A. Allan Lam P. Ly Ann J. Conway Robert I. McLachlan David J. Handelsman | 2012 | Clin Endocrinol2012，，5： | 1 |
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