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| 1 | Dietary and metabolomic determinants of relapse in ulcerative colitis patients: A pilot prospective cohort study显示文摘AIM To identify demographic, clinical, metabolomic, and lifestyle related predictors of relapse in adult ulcerative colitis(UC) patients.METHODS In this prospective pilot study, UC patients in clinical remission were recruited and followed-up at 12 mo to assess a clinical relapse, or not. At baseline information on demographic and clinical parameters was collected. Serum and urine samples were collected for analysis of metabolomic assays using a combined direct infusion/liquid chromatography tandem mass spectrometry and nuclear magnetic resolution spectroscopy. Stool samples were also collected to measure fecal calprotectin(FCP). Dietary assessment was performed using a validated self-administered food frequency questionnaire. RESULTS Twenty patients were included(mean age: 42.7 ± 14.8 years, females: 55%). Seven patients(35%) experienced a clinical relapse during the follow-up period. While 6 patients(66.7%) with normal body weight developed a clinical relapse, 1 UC patient(9.1%) who was overweight/obese relapsed during the follow-up(P = 0.02). At baseline, poultry intake was significantly higher in patients who were still in remission during follow-up(0.9 oz vs 0.2 oz, P = 0.002). Five patients(71.4%) with FCP > 150 μg/g and 2 patients(15.4%) with normal FCP(≤ 150 μg/g) at baseline relapsed during the follow-up(P = 0.02). Interestingly, baseline urinary and serum metabolomic profiling of UC patients with or without clinical relapse within 12 mo showed a significant difference. The most important metabolites that were responsible for this discrimination were trans-aconitate, cystine and acetamide in urine, and 3-hydroxybutyrate, acetoacetate and acetone in serum. CONCLUSION A combination of baseline dietary intake, fecal calprotectin, and metabolomic factors are associated with risk of UC clinical relapse within 12 mo. | Ammar Hassanzadeh Keshtel iFloris F van den Brand Karen L Madsen Rupasri Mandal Rosica ValchevaKaren I Kroeker Beomsoo Han Rhonda C Bell Janis Cole Thomas Hoevers David S Wishart Richard N Fedorak Levinus A Dieleman | 2017 | World Journal of Gastroenterology2017，23，21： | 9 |
| 2 | Should antibiotics be administered before arthroscopic knee surgery? A systematic review of the literature显示文摘AIM To explore the current evidence surrounding the administration of prophylactic antibiotics for arthroscopic knee surgery. METHODS Databases were searched from inception through May of 2018 for studies examining prophylactic antibiotic use and efficacy in knee arthroscopy. Studies with patient data were further assessed for types of arthroscopic procedures performed,number of patients in the study,use of antibiotics,and outcomes with the intention of performing a pooled analysis. Data pertaining to 'deep tissue infection' or 'septic arthritis' were included in our analysis. Reported data on superficial infection were not included in our data analysis. For the pooled analysis,a relative risk ratio was calculated and χ~2 tests were used to assess for statistical significance between rates of infection amongst the various patient groups. Post hoc power analyses were performed to compute the statistical power obtained from our sample sizes. Number needed to treat analyses were performed for statistically significant differences by dividing 1 by the difference between the infection rates of the antibiotic and no antibiotic groups. An alpha value of 0.05 was used for our analysis. Study heterogeneity was assessed by Cochrane's Q test as well as calculation of the I^2 value.RESULTS A total of 49682 patients who underwent knee ar-throscopy for a diverse set of procedures across 19 studies met inclusion critera for pooled analysis. For those not undergoing graft procedures,there were 27 cases of post-operative septic arthritis in 34487 patients(0.08%) who received prophylactic antibiotics and 16 cases in 10911(0.15%) who received none [risk ratio(RR) = 0.53,95% confidence interval(CI): 0.29-0.99,P = 0.05]. A sub-group analysis in which bony procedures were excluded was performed which found no significant difference in infection rates between patients that received prophylactic antibiotics and patients that did not(P > 0.05). All anterior cruciate ligament reconstruction studies used prophylactic antibiotics,but two studies investigating the effect of soaking the graft in vancomycin in addition to standard intravenous(IV) prophylaxis were combined for analysis. There were 19 cases in 1095 patients(1.74%) who received IV antibioitics alone and no infections in 2034 patients who received IV antibiotics and had a vancomycin soaked graft(RR = 0.01,95%CI: 0.001-0.229,P < 0.01).CONCLUSION Prophylactic antibiotics are effective in preventing septic arthritis following simple knee arthroscopy. In procedures involving graft implantation,graft soaking reduces the rate of infection. | John Carney Nathanael Heckmann Erik N Mayer Ram K Alluri Carleton Thomas Vangsness George F Hatch Ⅲ Alexander E Weber | 2018 | World Journal of Orthopedics2018，9，11： | 2 |
| 3 | The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase显示文摘 | Thomas F Franke Sung-Il Yang Tung O Chan Ketaki Datta Andrius Kazlauskas Deborah K Morrison David R Kaplan Philip N Tsichlis | 1995 | Cell1995，，5： | 2 |
| 4 | Biomechanical Analysis of Distal Femur Fracture Fixation: Fixed-Angle Screw-Plate Construct Versus Condylar Blade Plate显示文摘 | Thomas F Higgins Gavin Pittman Jerod Hines Kent N Bachus | 2007 | Journal of Orthopaedic Trauma2007，，1： | 2 |
| 5 | Carbon and nitrogen dynamics in ageing earthworm casts in grasslands of the eastern plains of Colombia 显示文摘 | DECAENS T RANGEL A F ASAKAWA N THOMAS R J | 1999 | Biology and Fertility of Soils1999，30，1： | 1 |
| 6 | Robust analysis of the yeast proteome under 50 kDa by molecular-massbased fractionation and top-down mass spectrometry显示文摘 | Kellie J F Catherman A D Durbin K R Tran J C Tipton J D Norris J L Witkowski C E 2nd Thomas P M Kelleher N L | | 0，，01： | 1 |
| 7 | Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow 显示文摘 | Thomas S N Zhu F Schnaar R L | 2008 | J Biol Chem2008，283，15： | 1 |
| 8 | Photocatalytic Generation of Hydrogen from Methanol显示文摘 | Zabidi N A Mohd Thomas T F | 1998 | J Phys Sci1998，9，： | 1 |
| 9 | Estimating leaf water content by reflectance measurement显示文摘 | Thomas J R Namken L N Oerther G F | 1971 | Agronomy Journal1971，63，： | 1 |
| 10 | Seroprevalence of canine parvovirus in wild coyotes from Texas, Utah, and Idaho (1972-1983) 显示文摘 | Thomas N J Foreyt W J Evermann J F | 1984 | J AM Vet Med Assoc1984，185，： | 1 |
| 11 | Seasonal changes in the respiratory electron transport system (ETS) and respiration of the zebra mussel,Dreissena polymorpha in Saginaw Bay?Lake Huron显示文摘 | DAVID L F THOMAS F N THOMAS H J | 2001 | Hydrobiologia2001，448，： | 1 |
| 12 | Bacterocins:safe,natural antimicrobials for food preservation显示文摘 | Jennifer C Thomas J M Ingolf F N | 2001 | International Journal of Food Microbiology2001，71，： | 1 |
| 13 | The Arabidopsis CDPK-SnRK superfamily of protein kinases显示文摘 | Hrabak E M Chan C W Gribskov M Harper J F Choi J H Halford N KUdla J Luan S Nimmo H G Sussman M R Thomas M Walker-simmons K Zhu J K Harmon A C | 2003 | Plant Physiology2003，132，： | 1 |
| 14 | The archaeal flagellum:a dif-ferent kind of prokaryotic motility structure显示文摘 | Thomas N A Bardy S L Jarrell K F | | 0，，02： | 1 |
| 15 | Bacteriocin : Sate, natural antimicrobials for food pres- Exwation显示文摘 | Cleveland J Thomas J M Ingolf F N | 2001 | Inter Food Microbial2001，71，1： | 1 |
| 16 | Batch test for assessing the mineralization of ^14C-radiolabeled compounds under realistic Anaerobic conditions显示文摘 | Barbara A N Thomas W F | 1996 | Environ Sci Technol1996，30，： | 1 |
| 17 | Bacteriocins: safe, natural antimicrobials for food preservation显示文摘 | JENNIFER C THOMAS J M INGOLF F N | 2001 | lnternat J Food Micro biol2001，71，1： | 1 |
| 18 | Development of a real-time Staphylococcus aureus and MRSA (SAM-)PCR for routine blood euhuer 显示文摘 | Thomas L C Gidding H F Ginn A N | 2007 | Microbiol Methods2007，68，2： | 1 |
| 19 | Disturbance history and dynamics of an old-growth mixed species mounta in forest in the Slovenian Alps 显示文摘 | Dejan F Thomas A N Jurij D | 2009 | Forest Ecology and Management2009，257，： | 1 |
| 20 | Phosphorylation atserines 104 and 106 by Erk1/2 MAPK is important for estrogenreceptor-alpha activity显示文摘 | Thomas RS Sarwar N Phoenix F | 2008 | J Mol Endocrinol2008，40，4： | 1 |
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