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| 1 | Epistaxis in end stage liver disease masquerading as severe upper gastrointestinal hemorrhage显示文摘AIM:To describe the prevalence,diagnosis,treatment,and outcomes of end stage liver disease(ESLD) patients with severe epistaxis thought to be severe upper gastrointestinal hemorrhage(UGIH).METHODS:This observational single center study included all consecutive patients with ESLD and epistaxis identified from consecutive subjects hospitalized with suspected UGIH and prospectively enrolled in our databases of severe UGIH between 1998 and 2011.RESULTS:A total of 1249 patients were registered for severe UGIH in the data basis,461(36.9%) were cirrhotics. Epistaxis rather than UGIH was the bleeding source in 20 patients. All patients had severe coagulopathy. Epistaxis was initially controlled in all cases. Fifteen(75%) subjects required posterior nasal packing and 2(10%) embolization in addition to correction of coagulopathy. Five(25%) patients died in the hospital,12(60%) received orthotopic liver transplantation(OLT),and 3(15%) were discharged without OLT. The mortality rate was 63% in patients without OLT.CONCLUSION:Severe epistaxis in patients with ESLD is(1) a diagnosis of exclusion that requires upper endoscopy to exclude severe UGIH;and(2) associated with a high mortality rate in patients not receiving OLT. | Marine Camus Dennis M Jensen Jason D Matthews Gordon V Ohning Thomas O Kovacs Rome Jutabha Kevin A Ghassemi Gustavo A Machicado Gareth S Dulai | 2014 | World Journal of Gastroenterology2014，20，38： | 3 |
| 2 | Genotype phenotype correlation in Wilson's disease within families-a report on four south Indian families显示文摘AIM: To study the genotype phenotype correlation in Wilson's disease (WD) patients within families. METHODS: We report four unrelated families from South India with nine members affected with WD. Phenotype was classified as per international consensus phenotypic classifi cation of WD. DNA was extracted from peripheral blood and 21 exons of ATP7B gene and flanking introns were amplified by polymerase chain reaction (PCR). The PCR products were screened for mutations and the aberrant products noted on screening were sequenced. RESULTS: Four separate ATP7B mutations were found in the four families. ATP7B mutations were identical amongst affected members within each family. Three families had homozygous mutations of ATP7B gene while one family had compound heterozygous mutation, of which only one mutation was identifi ed. We noted concordance between ATP7B gene mutation and Wilson's disease phenotype amongst members within each family. The age of onset of symptoms or of detection of asymptomatic disease, baseline serum ceruloplasmin and baseline urinary copper levels were also similar in affected members of each family. Minor differences in phenotype and baseline serum ceruloplasmin level were noted in one family.CONCLUSION: We report concordance between ATP7B mutation and WD phenotype within each family with > 1 member affected with WD. Homozygous ATP7B mutation was present in 3 of the 4 families studied. Our report supports allelic dominance as a determinant of WD phenotype. However, in one family with compound heterozygous mutation, there was a similar WD phenotype which suggests that there may be other factors determining the phenotype. | S Santhosh RV Shaji CE Eapen V Jayanthi S Malathi P Finny N Thomas M Chandy G Kurian GM Chandy | 2008 | World Journal of Gastroenterology2008，14，29： | 3 |
| 3 | 直接评估吗啡刺激糖尿病人隐静脉内皮一氧化氮释放减少显示文摘to directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the μopiate receptor, which has been linked with NO release. METHODS: Saphenous vein segments from patients with type 2 diabetes ( n = 12) and patients without diabetes (n =8) were obtained. The release of NO was measured directly from the endothelium using a NO-specific amperometric probe. NΩ-nitro-L-arginine methyl ester (L-NAME, 0.1 mmol/L), a NO synthase (NOS) inhibitor, or morphine (1 μmol/L), a stimulant, was administered and the measurements were repeated. Values were reported relative to the mean initial measurement of NO release from diabetic endothelium, which was defined as the relative zero level of NO release. A RT-PCR was then performed on the endothelium to measureμ opiate receptor expression. RESULTS: Diabetic patients (n = 12) showed a relative and significantly diminished basal level of released NO, (0.049± 0.012) nmol/L, compared | Thomas V BILHNGER, James A VOSSWINKEL, Patrick CADET, Christos M RIALAS, Harold I MAGAZINE, George B STEFANO(Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19-080, Stony Brook, New York 11794-8191 Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York , USA) | 2002 | Acta Pharmacologica Sinica2002，23，2： | 3 |
| 4 | Reninoma: case report and literature review显示文摘 | Lara Wong Thomas HS Hsu Mark G Perlroth Lawrence V Hofmann Claudia M Haynes Laurence Katznelson | 2008 | Journal of Hypertension2008，，2： | 2 |
| 5 | Capacitive sensor for the measurement of VFTO in GIS显示文摘 | Vinod Kumar V Joy Thomas M | 1999 | lEE Conference Publication High Voltage Engineering Symposium1999，，467： | 2 |
| 6 | A new laboratory EUV reflectometer for large optics using a laser plasma source显示文摘 | LUDWING V L THOMAS B HERMANN M | 2003 | SPIE2003，5038，： | 2 |
| 7 | Post-collisional magmatism in the central East African orogen: The Maevarano suite of north Madagascm显示文摘 | Goodenough K M Thomas R J De Waele B Key R M Schofield D I Bauer W Tucker R D Kafahatelo J M Rabrimanana M Ralison A V Randriamananjma T | 2010 | Lithos2010，116，12： | 1 |
| 8 | Partial Least-squares Methods for Spectral Analyses Relation to Other Quantitative Calibration Methods and the Extraction of Qualitative Information 显示文摘 | Haaland D M Thomas E V | 1988 | Anal Chem1988，60，： | 1 |
| 9 | Crystal doping aided by rapid expansion of supercritical solutions 显示文摘 | Chandra V Matthew J M Thomas E N | 2002 | AAPS Pharm-SciTech2002，3，4： | 1 |
| 10 | Alkali treatment for rapid preparation of plant material for reliable PCR analysis显示文摘 | Klimyuk V I Carroll BJ Thomas C M | 1993 | Plant J1993，，3： | 1 |
| 11 | Increased persistence of antifouling paint biocides when associ- ated with paint particles 显示文摘 | Thomas K V McHugh M Hilton M | 2003 | Environmental Pollution2003，123，1： | 1 |
| 12 | Late paleocene to eocene paleocenography of the equatorial pacific ocean: stable isotopes recorded at ocean drilling program site 865, allison guyot显示文摘 | Zachos J C Thomas E Parrow M Paul C K Kelly D C Silva I P Sliter W V Lohmann K C | 1995 | Paleoceanography1995，10，： | 1 |
| 13 | Ex vivo expansion of polyclonal and antigen-specific cytotoxic T lymphocytes by artificial APCs expressing ligands for the T-cell receptor, CD28 and 4-1BB显示文摘 | Maus M V Thomas A K Leonard D G | 2002 | Nat Biotechnol2002，20，： | 1 |
| 14 | 显示文摘 | THOMAS M M MAURENE K V ERIC S C | 1997 | Cytometry1997，29，： | 1 |
| 15 | Some effects of enhanced UV-B irradiation the growth and composition of plants显示文摘 | TEVINI M IWANZIK W THOMA V | 1981 | Planta1981，153，3： | 1 |
| 16 | A functional transsulfuration pathway in the brain links to glutathione homeostasis显示文摘 | Vitvitsky V Thomas M Ghorpade A | 2006 | J Biol Chem2006，281，35： | 1 |
| 17 | Biocatalysis: applications and potentials for the chemical industry 显示文摘 | THOMAS S M DICOSIMO R NAGARAJAN V | 2002 | Trends in Biotechnology2002，20，6： | 1 |
| 18 | In situ calibration of apassive sampling device for selected illicit drugs and their metab-olites in wastewater, and subsequent year-long assessment ofcommunity drug usage 显示文摘 | HARMAN C REID M THOMAS K V | 2011 | Environmental Science & Technolo-gy2011，45，13： | 1 |
| 19 | Left ventricular dysfunction after long-term right ventrieular apical pacing in the young显示文摘 | TANTENGCO M V THOMAS R L KARPAWICH P P | 2001 | J Am Coll Cardiol2001，1537，： | 1 |
| 20 | Germinal transpositions of the maize element Dissocia-tion from T-DNA loci in tomato显示文摘 | Carroll B J Klimyuk V I Thomas C M Bishop G J HarrisonK Scofield S R Jones J D G | | 0，，： | 1 |
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