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| 1 | Preparation of biodegradable insulin nanocapsules from biocompatiblemicroemulsions显示文摘 | Suchat Watnasirichaikul Nigel M Davies Thomas Rades | 2000 | Pharm Res2000，17，6： | 1 |
| 2 | Exploring the fate of liposomes in the intestine by dynamic in vitro lipolysis显示文摘 | Johannes Parmentier Nicky Thomas Anette Müllertz Gert Fricker Thomas Rades | 2012 | International Journal of Pharmaceutics (-)2012，，1： | 1 |
| 3 | Characterising lipid lipolysis and its implication in lipid-based formulation development 显示文摘 | THOMAS N HOLM R RADES T | 2012 | AAPS J2012，14，2： | 1 |
| 4 | Preparation of biodegradable insulin nanocapsules from biocompatible microemulsions 显示文摘 | Suchat Watnasirichaikul Nigel M Davies Thomas Rades | 2000 | Pharm Res2000，6，： | 1 |
| 5 | A New Method for the Determination of the Unfrozen Matrix Concentration and the Maximal Freeze-concentration显示文摘 | Jens Liesebach Thomas Rades Miang Lim | 2003 | Thermochimica Acta2003，401，： | 1 |
| 6 | Formulation of self-nanoemulsifying drug delivery systems containing monoacyl phosphatidylcholine and Kolliphor^(■) RH40 using experimental design显示文摘The development of self-nanoemulsifying drug delivery systems(SNEDDS) to enhance the oral bioavailability of lipophilic drugs is usually based on traditional one-factor-at-a-time approaches. These approaches may be inadequate to analyse the effect of each excipient and their potential interactions on the emulsion droplet size formed when dispersing the SNEDDS in an aqueous environment. The current study investigates the emulsion droplet sizes formed from SNEDDS containing different levels of the natural surfactant monoacyl phosphatidylcholine to reduce the concentration of the synthetic surfactant polyoxyl 40 hydrogenated castor oil(Kolliphor ~? RH40). Monoacyl phosphatidylcholine was used in the form of Lipoid S LPC 80(LPC, containing approximately 80% monoacyl phosphatidylcholine, 13% phosphatidylcholine and 4% concomitant components). The investigated SNEDDS comprised of long-chain or medium-chain glycerides(40% to 75%), Kolliphor ~? RH40(5% to 55%), LPC(0 to 40%) and ethanol(0 to 10%). D-optimal design, multiple linear regression, and partial least square regression were used to screen different SNEDDS within the investigated excipient ranges and to analyse the effect of each excipient on the resulting droplet size of the dispersed SNEDDS measured by dynamic light scattering. All investigated formulations formed nano-emulsions with droplet sizes from about 20 to 200 nm. The use of mediumchain glycerides was more likely to result in smaller and more monodisperse droplet sizes compared to the use of long-chain glycerides. Kolliphor~? RH40 exhibited the most significant effect on reducing the emulsion droplet sizes. Increasing LPC concentration increased the emulsion droplet sizes, possibly because of the reduction of Kolliphor~? RH40 concentration. A higher concentration of ethanol resulted in an insignificant reduction of the emulsion droplet size. The study provides different ternary diagrams of SNEDDS containing LPC and Kolliphor ~? RH40 as a reference for formulation developers. | Thuy Tran Thomas Rades Anette Müllertz | 2018 | Asian Journal of Pharmaceutical Sciences2018，13，6： | 1 |
| 7 | Preparation of biodegradable insulin nanocapsules from biocompatible microemulsions显示文摘 | SUCHAT WATNASIRICHAIKUL NIGEL M DAVIES THOMAS RADES | 2000 | Pharm Res2000，17，6： | 1 |
| 8 | A New Method for theDetermination of the Unfrozen Matrix Concentration and the Maxi-mal Freeze - concentration 显示文摘 | Jens Liesebach Thomas Rades Miang Lim | 2003 | Thermochimica acta2003，401，： | 1 |
| 9 | An oral delivery system for indomethicin engineered from cationic lipid emulsions and silica nanoparticles显示文摘 | Spomenka Simovic He Hui Yunmei Song Andrew K. Davey Thomas Rades Clive A. Prestidge | 2010 | Journal of Controlled Release2010，，3： | 1 |
| 10 | Non-destructive quantification of pharmaceutical tablet coatings using terahertz pulsed imaging and optical coherence tomography显示文摘 | Shuncong Zhong Yao-Chun Shen Louise Ho Robert K. May J. Axel Zeitler Mike Evans Philip F. Taday Michael Pepper Thomas Rades Keith C. Gordon Ronny Müller Peter Kleinebudde | 2010 | Optics and Lasers in Engineering2010，，3： | 1 |
| 11 | Preparation of biodegradable insulin nanocapsules from biocompatible microemulsions显示文摘 | SUCHAT WATNASIRICHAIKUL NIGEL M DAVIES THOMAS RADES | 2000 | Pharm Res2000，176，： | 1 |
| 12 | Exploring the utility of the Chasing Principle:influence of drug-free SNEDDS composition on solubilization of carvedilol, cinnarizine and R3040 in aqueous suspension显示文摘This study assessed the influence of the composition of drug-free SNEDDS co-dosed with aqueous suspensions of carvedilol(CAR), cinnarizine(CIN) or R3040 on drug solubilization in a twocompartment in vitro lipolysis model. Correlation of drug log P or solubility in SNEDDS with drug solubilization during in vitro lipolysis in the presence of drug-free SNEDDS was assessed. SNEDDS with varying ratios of soybean oil:Maisine 35-1(1:1, w/w) and Kolliphor RH40, with ethanol at 10%(w/w) were used. SNEDDS were named F65, F55 and F20(numbers refer to the percentage of lipids) and aqueous suspensions without drug-free SNEDDS(F0) were also analyzed. While the ranking order of drug solubilization was F65? F55? F204F0 for CAR; F65? F554F204F0 for CIN and F65? F55? F204F0 for R3040-with higher CAR solubilization than for R3040 and CIN-the ranking of S_(eq)of CAR, CIN and R3040 in SNEDDS was F65 o F55o F20, F65? F554F20 and F654F554F20, respectively. Therefore, the composition of SNEDDS influenced the solubilization of CIN, but not CAR and R3040. Furthermore, high S_(eq) in SNEDDS did not reflect high drug solubilization. As CAR(log P 3.8) showed higher solubilization than CIN(log P 5.8) and R3040(log P 10.4), a correlation between drug log P and drug solubilization was observed. | Scheyla Daniela Siqueira J?rgensen Thomas Rades Huiling Mu Kirsten Graeser Anette Müllertz | 2019 | Acta Pharmaceutica Sinica B2019，9，1： | 0 |
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