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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Hyperspectral versus multispectral data for estimating leaf area index in four different biomes显示文摘 | Kyu-Sung Lee Warren B Cohen Robert E Kennedy Thomas K Maiersperger Stith T Gower | 2004 | Remote Sensing of Environment2004，，3： | 2 |
| 3 | Comparison of cytokine and phosphoprotein profiles in idiopathic and Crohn’s disease-related perianal fistula显示文摘BACKGROUND Perianal fistulae are either primary(idiopathic)or secondary[commonly associated with Crohn’s disease,(CD)].It is assumed,although not proven,that the pathophysiology differs.AIM To systematically compare the clinical phenotypes,cytokine and phosphoprotein profiles of idiopathic and CD-related perianal fistulae.METHODS Sixty-one patients undergoing surgery for perianal fistula were prospectively recruited(48 idiopathic,13 CD)into a cohort study.Clinical data,including the Perineal Disease Activity Index(PDAI)and EQ-5D-5L were collected.Biopsies of the fistula tract,granulation tissue,internal opening mucosa and rectal mucosa were obtained at surgery.Concentrations of 30 cytokines and 39 phosphoproteins were measured in each biopsy using a magnetic bead multiplexing instrument and a chemiluminescent antibody array respectively.Over 12000 clinical and 23500 laboratory measurements were made.RESULTS The PDAI was significantly higher(indicating more active disease)in the CD group with a mean difference of 2.40(95%CI:0.52-4.28,P=0.01).Complex pathoanatomy was more prevalent in the CD group,namely more multiple fistulae,supralevator extensions,collections and rectal thickening.The IL-12p70 concentration at the internal opening specimen site was significantly higher(median difference 19.7 pg/mL,99%CI:0.2-40.4,P=0.008)and the IL-1RA/IL-1βratio was significantly lower in the CD group at the internal opening specimen site(median difference 15.0,99%CI=0.4-50.5,P=0.008).However in the remaining 27 cytokines and all 39 of the phosphoproteins across the four biopsy sites,no significant differences were found between the groups.CONCLUSION CD-related perianal fistulae are more clinically severe and anatomically complex than idiopathic perianal fistulae.However,overall there are no major differences in cytokine and phosphoprotein profiles. | James B Haddow Omar Musbahi Thomas T MacDonald Charles H Knowles | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，4： | 2 |
| 4 | Registration of LD00- 2817P soybean germplasm line with resistance to soybean cyst nematode from PI 437654 显示文摘 | Diets B W Cary T Thomas D | 2010 | Journal of Plant Registrations2010，4，2： | 1 |
| 5 | Post-collisional magmatism in the central East African orogen: The Maevarano suite of north Madagascm显示文摘 | Goodenough K M Thomas R J De Waele B Key R M Schofield D I Bauer W Tucker R D Kafahatelo J M Rabrimanana M Ralison A V Randriamananjma T | 2010 | Lithos2010，116，12： | 1 |
| 6 | Improving the nutritive value of full-fat rice bran for broiler chickens using a lipase-basedenzyme preparation显示文摘 | Tan S H Thomas D V Cumden B Je t al | 2000 | Asian Australasian Journal of Animal Sciences2000，13，3： | 1 |
| 7 | Insight into steroid scaffold formation from the structure of human oxidosqualene cyclase 显示文摘 | Thoma R Schulz-Gasch T D'Arcy B | 2004 | Nature2004，432，7013： | 1 |
| 8 | Invasive Pneumococcal Disease in Children 5 Years After Conjugate Vaccine Introduction - Eight States, 1998-2005显示文摘 | Reingold A Hadler J Farley M M Harrison L Lynfield R Lexau C Bennett N Thomas A Craig A S Smith P J Beall B Whitney C G Moore M Pilishvili T | 2008 | MMWR Morbidity and Mortality Weekly Report2008，，6： | 1 |
| 9 | Role of serum leptin, insulin, and estrogen levels as potential mediators of the relationship between fat mass and bone mineral density in men versus women显示文摘 | Thomas T Burguera B Melton III LJ | 2001 | Bone2001，29，： | 1 |
| 10 | Effect of restricted feeding on the relationship between hypophysial portal concentrations of growth hormone ( GH)-releasing factor and somatostatin, and jugular concentrations of GH in ovariectomized ewes 显示文摘 | Thomas G B Cummins J T Francis H | 1991 | Endocrinology1991，128，： | 1 |
| 11 | Poly ( amidoamine ) Dendrimer-Based Multifunctional Engineered Nanodevice for Cancer Therapy 显示文摘 | Majoros I J Thomas T P Mehta C B | 2005 | Journal of Medicinal Chemistry2005，48，： | 1 |
| 12 | Creep and Fracture of Cast Ni - Cr - base Alloy Containing Trace Elements 显示文摘 | THOMAS G B GIBBONS T B | 1984 | Materials Science Engineering1984，67，1： | 1 |
| 13 | Bit error simulation for/4 DQPSK mobile radio communications using TwoRay and measurement-based impulse response models显示文摘 | Fung V Rappaport T S Thoma B | | 0，，03： | 1 |
| 14 | A trypsin-solubilized laccase from pharate pupal integument of the tobacco homworm, Manduca sexta 显示文摘 | Thomas B R Yonekura M Morgan T D | 1989 | Insect Biochem1989，19，7： | 1 |
| 15 | The relationship of bloodand urine-boron to boron exposure in borax-workers and the usefulness of urine-boron as an exposure maker显示文摘 | Dwight Culver B Petex T Shen Thomas H T | 1994 | Environmental Health Perspectives1994，102，7： | 1 |
| 16 | Analysis of Holocene sedimentary features on the Adriatic shelf from 3D very high resolution seismic data (triad survey) 显示文摘 | MARSSET T MARSSET B THOMAS Y | 2004 | Marine Geology2004，213，： | 1 |
| 17 | Bibliotherapy and Perceptions of Death by Young Children显示文摘 | Jeffrey T Thomas ES Michael B | 1998 | Journal of Poetry Therapy1998，12，2： | 1 |
| 18 | Properties of steel fiber reinforced concrete under cyclic loading显示文摘 | BONG Y B CHENG T THOMAS H | 1998 | ACI Materials Journal1998，95，2： | 1 |
| 19 | Coarse woody debris in Douglas-fir forests of western Oregon and Washington显示文摘 | Spies T A Franklin J P Thomas T B | 1988 | Ecolo- gy1988，69，： | 1 |
| 20 | Thermal decomposition of energetic materials 85 : Cryogels of nanoscale hydrazininum diperchlorate in resorcinol-formaldehyde显示文摘 | Bryce C T Thomas B B | 2003 | Propeellants Explosives Pyro- technics2003，28，2： | 1 |
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