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| 1 | 近百年中国气温变化中的不确定性估计显示文摘利用均一化的中国近百年气温观测数据,结合英国East Anglia大学气候研究中心(CRU)的CRUTEM3气温数据集中中国周边国家长序列资料对20世纪前50年资料进行了补充,研制了中国及周边地区近百年逐月5°×5°气温网格数据集,并综合系统考虑了该气温数据集中存在的3类误差(台站误差、抽样误差和偏差误差)导致的不确定性水平,重新构建了近百年全国气温变化序列,并给出了各种不确定性水平,得出了近百年中国气温变化的最新估计.基于上述数据集系统性地对中国近100年地表气温变化趋势进行了重新估计.结果显示:1900~2006年中国气温变化速度为(0.09±0.017)℃/10a;冬季最大,为(0.14±0.021)℃/10a;夏季最小为(0.04±0.017)℃/10a;春季为(0.11±0.021)℃/10a;秋季为(0.07±0.017)℃/10a.近50年(1954~2006年)气温增暖趋势约为(0.26±0.032)℃/10a,近30年(1979~2006年)增暖趋势为(0.45±0.13)℃/10a,气温增暖速率呈明显加剧趋势,值得引起注意.从地理分布上来看,东北、西北和华北地区的增暖幅度最为明显,而西南、华南地区增暖幅度最小,这种变化在近100,50和30年具有较好的一致性. | 李庆祥 董文杰 李伟 高小蓉 JONES Phil KENNEDY John PARKER David | 2010 | 科学通报2010，55，16： | 82 |
| 2 | The immune tolerant phase of chronic HBV infection: new perspectives on an old concept显示文摘长期的肝炎 B 病毒(HBV ) 感染通过强烈与耐心的年龄被联系的不同疾病阶段进行。所谓的免疫者容忍(信息技术) 阶段代表感染的古典早阶段;它与 HBV 复制的高水平和肝发炎的临床的符号的缺乏被联系。HBV 感染的这个阶段是否也与免疫学的被联系, “ 展示; tolerance' 最近被质问了。这里,我们考察数据那争论有免疫力的忍耐的这个概念然后建议发生在 CHB 感染的这个早阶段期间的 immunopathological 事件的其他的解释。 | Antonio Bertoletti Patrick T Kennedy | 2015 | Cellular & Molecular Immunology2015，12，3： | 36 |
| 3 | 广西南宁地区5岁以下儿童细菌性脑膜炎的流行病学监测显示文摘目的 分析南宁地区5岁以下儿童细菌性脑膜炎的发病率、流行特征、病原谱、后遗症等的特点。方法 采取以监测区域所有医院、卫生院及村卫生室为监测单位,以人口为基数的流行病学监测方法,以符合筛选标准的病例作为研究病例;采集脑脊液(CSF)和血液标本,按照统一规程进行病原学分离和临床诊断。结果 在26个月的监测期内,在5岁以下儿童中共收集到符合筛检标准的研究病例1272例,其中临床诊断病例265例,临床诊断病例年均发病率为86.36/10万,病原确诊细菌性脑膜炎病例38例,年均发病率为12.38/10万。确诊病例的病原谱以葡萄球菌为主,次为大肠埃希菌和肺炎双球菌(Sp);年龄分布以1月龄以下年龄组为最高,次为1~12月龄组,1~24月龄组是Sp和流感嗜血杆菌(Hi)所致脑膜炎的高发年龄组;并发症和后遗症发生率分别为13.16%和0.00%,病死率18.42%。实验室分别从1193份血培养标本和1211份CSF培养标本中分离出40株Hi和23株Sp等致病菌,但均未分离到脑膜炎奈瑟菌(Nm)。结论 首次证实广西存在Hi所致脑膜炎,年均发病率为0.98/10万,处于较低发病水平;确诊细菌性脑膜炎年均发病率12.38/10万,是当前危及儿童健康的重要问题;确诊细菌性脑膜炎的病原谱以葡萄球菌为主。 | 董柏青 唐振柱 林玫 李翠云 谭冬梅 梁大斌 廖和壮 刘先知 权怡 方锦嵩 吴兴华 秦卫文 Kilgore PE Kennedy WA 徐志一 ClemensJD | 2004 | 中华流行病学杂志2004，25，5： | 30 |
| 4 | Assessment of the uncertainties in temperature change in China during the last century显示文摘We have used the China Homogenized Historic Temperature dataset and some long-term station series of the neighbor countries from CRUTEM3,a 5°×5° gridded dataset of monthly mean temperature since 1900,to provide a 107-year record of surface temperature trends and variability.We derived a comprehensive set of uncertainty estimates to accompany the data:measurement and sampling errors,uncertainties in temperature bias estimates,and uncertainties arising from limited observational coverage on large-scale averages have all been estimated.We reanalysed the temperature changes during the period of record.The best estimates of trends for 1900-2006 with uncertainties at 95% confidence range are about 0.09±0.017°C/decade for the year as a whole,and 0.14±0.021°C/decade,0.11±0.021°C/decade,0.04±0.017°C/decade,and 0.07±0.017°C/decade for winter,spring,summer and autumn respectively.For 1954-2006,the trends for annual,winter,spring,summer and autumn are:0.26±0.032°C/decade,0.35±0.046°C/decade,0.25±0.051°C/decade,0.16±0.037°C/decade and 0.22±0.055°C/decade.Winter saw the most significant warming trend in both 1900-2006 and 1954-2006,while during the most recent period(the satellite era,1979-2006),all the seasons show similar warming trends:0.45±0.13°C/decade,0.51±0.11°C/decade,0.52±0.16°C/decade,0.37±0.10°C/decade and 0.50±0.16°C/decade for annual,winter,spring,summer and autumn.Trends arising from urbanization have been evaluated as less than 5% of the total warming trend for 1951-2001,so this bias was not removed. | LI QingXiang DONG WenJie LI Wei GAO XiaoRong JONES P KENNEDY J PARKER D | 2010 | Chinese Science Bulletin2010，55，19： | 26 |
| 5 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 6 | 西藏羊八井热田地热流体成因及演化的惰性气体制约显示文摘地热流体中惰性气体的相对丰度和同位素组成 ,不仅可以揭露热田的热源性质 ,而且还能够揭示深、浅层地热流体的内在联系和演化过程等。在西藏羊八井热田的地热气体中 ,已检测出大量的 4 He组分 ,3He/ 4 He值是大气的 0 .0 87~ 0 .2 5 9倍 ,表明深部地壳物质的局部熔融为热田提供能量。浅层地热流体的 3He/ 4 He值自西北向东南呈降低趋势 ,与热储温度的变化相一致 ,反映出侧向运移时补充了更多的壳源氦。热田北区深层地热流体具有稍高的 3He/ 4 He值 ,是浅层地热流体的母源。气体中氪和氙的相对丰度具有大气降水成因的特征。结合现有的实际资料 。 | 赵平 Mack KENNEDY 多吉 谢鄂军 杜少平 David SHUSTER 金建 | 2001 | 岩石学报2001，17，3： | 24 |
| 7 | Current management of talar osteochondral lesions显示文摘Osteochondral lesions of the talus(OLT) occur in up to 70% of acute ankle sprains and fractures. OLT have become increasingly recognized with the advancements in cartilage-sensitive diagnostic imaging modalities. Although OLT may be treated nonoperatively, a number of surgical techniques have been described for patients whom surgery is indicated. Traditionally, treatment of symptomatic OLT have included either reparative procedures, such as bone marrow stimulation(BMS), or replacement procedures, such as autologous osteochondral transplantation(AOT). Reparative procedures are generally indicated for OLT < 150 mm^2 in area. Replacement strategies are used for large lesions or after failed primary repair procedures. Although shortand medium-term results have been reported, longterm studies on OLT treatment strategies are lacking. Biological augmentation including platelet-rich plasma and concentrated bone marrow aspirate is becoming increasingly popular for the treatment of OLT to enhance the biological environment during healing. In this review, we describe the most up-to-date clinical evidence of surgical outcomes, as well as both the mechanical and biological concerns associated with BMS and AOT. In addition, we will review the recent evidence for biological adjunct therapies that aim to improve outcomes and longevity of both BMS and AOT procedures. | Arianna L Gianakos Youichi Yasui Charles P Hannon John G Kennedy | 2017 | World Journal of Orthopedics2017，8，1： | 23 |
| 8 | Irritable bowel syndrome: A microbiome-gut-brain axis disorder?显示文摘Irritable bowel syndrome(IBS) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help diagnose the disorder and treatment options are limited to management of the symptoms. The concept of a dysregulated gut-brain axis has been adopted as a suitable model for the disorder. The gut microbiome may play an important role in the onset and exacerbation of symptoms in the disorder and has been extensively studied in this context. Although a causal role cannot yet be inferred from the clinical studies which have attempted to characterise the gut microbiota in IBS, they do confirm alterations in both community stability and diversity. Moreover, it has been reliably demonstrated that manipulation of the microbiota can influence the key symptoms, including abdominal pain and bowel habit, and other prominent features of IBS. A variety of strategies have been taken to study these interactions, including probiotics, antibiotics, faecal transplantations and the use of germ-free animals. There are clear mechanisms through which the microbiota can produce these effects, both humoral and neural. Taken together, these findings firmly establish the microbiota as a critical node in the gut-brain axis and one which is amenable to therapeutic interventions. | Paul J Kennedy John F Cryan Timothy G Dinan Gerard Clarke | 2014 | World Journal of Gastroenterology2014，20，39： | 20 |
| 9 | MicroRNA-21 as a potential colon and rectal cancer biomarker显示文摘Colorectal cancer(CRC)is one of the most common malignant diseases worldwide and the prognosis is still poor although much progress has been achieved in recent years.In order to reduce CRC-related deaths,many studies are aimed at identifying novel screeningand prognosis-related biomarkers.MicroRNAs(miRNAs)are a class of 18-27-nucleotide single-stranded RNA molecules that regulate gene expression at the posttranscriptional level.It has been demonstrated that miRNAs regulate a variety of physiological functions,including development,cell differentiation,proliferation,and apoptosis.They play important roles in various physiologic and developmental processes and in the initiation and progression of various human cancers.It has been shown that miRNAs can critically regulate tumor cell gene expression,and evidence suggests that they may function as both oncogenes and tumor suppressor genes.In CRC,miRNAs-21 is one of the most important miRNAs and is rapidly emerging as a novel biomarker in CRC,with good potential as a diagnostic and therapeutic target.In this review,we summarize the latest research findings of the clinicopathological relevance of miRNAs-21 in CRC initiation,development,and progress,highlighting its potential diagnostic,prognostic,and therapeutic application,as well as discuss-ing future prospects. | Tao Li Mei Ha Leong Bruce Harms Gregory Kennedy Lin Chen | 2013 | World Journal of Gastroenterology2013，19，34： | 16 |
| 10 | 运用ICF评定健康状况的影响显示文摘目的人们可能罹患各种疾病并且有不同的健康状况,但是为了充分认识人类生活所处的健康状况,需要有关疾病或健康状况对人类生活影响的综合性信息。本文要探讨健康状况的影响,健康状况可以用国际疾病分类(ICD)术语进行分类,功能概念用国际功能、残疾与健康分类(ICF)术语进行描述。本研究确定了一套ICF的分类类目作为功能属性,与ICD联合应用用于描述普遍的健康状况的影响。方法 用于描述任何健康状况下功能属性特征的ICF类目从3个主要的通用健康状况评定工具中选择出来,这三个工具是:世界卫生组织残疾评定量表2.0(WHODAS2.0)、世界健康调查(WHS)问卷和ICF核心分类集(ICF coresets)通用版类目的一个清单。结果 根据特定的功能领域建立了一套描述健康状况影响的ICF类目。结论 在ICD-11修订的背景之下,通过一系列的功能属性的ICF类目列表联合运用ICD和ICF可以实现两种分类的有价值的整合,有益于加强患者管理、干预方案的设计和健康结果的报告,能使我们将疾病的严重程度与疾病的影响区别开来。在卫生信息系统应用中,ICD-ICF联合运用建立了一种持续性卫生保健的共享的正式信息表征。 | Nenad Kostanjsek Sara Rubinelli Reuben Escorpizo Alarcos Cieza Cille Kennedy Gerold Stucki T.Bedirhan stün 张爱民 李沁燚 邱卓英 李建军 | 2011 | 中国康复理论与实践2011，17，1： | 12 |
| 11 | NEW DEVELOPMENTS IN WROUGHT 718-TYPE SUPERALLOYS显示文摘Research and development efforts are still very active on 718-type alloys although two major members of this widely used family, 718 and 625, were invented almost a half-century ago.Emphasis in this type of work at ATI Allvac is directed at improving existing alloys and developing new alloys to meet ever-increasing industrial demands.The improvement of existing alloys is exemplified by addition of minor elements P and B in alloy 718.The discovery of the beneficial effect of P and B in wrought alloy 718 led to development of a new, modified alloy, AllvacR 718ERR.A large effort has also been directed at studying the effects of major element modifications in 718-type alloys, and a new alloy, AllvacR 718PlusTM, has been developed.The new alloy has much better high temperature capability, especially thermal stability, approaching the level of Waspaloy but retains excellent processing characteristics, similar to alloy 718.Alloy 718PlusTM should be useful in any 718-type application requiring a higher working temperature.The properties and processing of this alloy are introduced in this paper. | R.L. Kennedy | 2005 | Acta Metallurgica Sinica(English Letters)2005，18，1： | 11 |
| 12 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 13 | Relationship between the exocrine and endocrine pancreas after acute pancreatitis显示文摘AIM:To determine the prevalence and time course of pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.METHODS:Relevant literature cited in three major biomedical journal databases(EMBASE,MEDLINE,and Scopus)was reviewed independently by two authors.There were no language constraints but the search was limited to human studies.Studies included were cohort studies of adult patients who were discharged after an attack of acute pancreatitis.Patients were excluded if they were under 18 years of age or had a previous diagnosis of prediabetes or diabetes mellitus,pancreatic exocrine insufficiency,or chronic pancreatitis.The main outcome measure was the prevalence of concomitant pancreatic exocrine insufficiency in patients who were diagnosed with prediabetes and diabetes mellitus after an attack of acute pancreatitis.Subgroup analysis was conducted for patients who were diagnosed with prediabetes only and those who were diagnosed withdiabetes mellitus only.Subgroup analysis looking at the time course of concomitant pancreatic exocrine and endocrine insufficiency was also conducted.Pooled prevalence and corresponding 95%confidence intervals were calculated for all outcome measures and P-values<0.05 were deemed statistically significant.RESULTS:Eight clinical studies comprising of 234patients met all eligibility criteria.The pooled prevalence of newly diagnosed prediabetes or diabetes in individuals after acute pancreatitis was 43%(95%CI:30%-56%).The pooled prevalence of pancreatic exocrine insufficiency in individuals after acute pancreatitis was 29%(95%CI:19%-39%).The prevalence of concomitant pancreatic exocrine insufficiency in individuals with newly diagnosed prediabetes or diabetes was 40%(95%CI:25%-55%).The prevalence of concomitant pancreatic exocrine insufficiency among individuals with prediabetes alone and diabetes mellitus alone was 41%(95%CI:12%-75%)and 39%(95%CI:28%-51%),respectively.Further analysis showed that the prevalence of concomitant pancreatic exocrine insufficiency in individuals with prediabetes or diabetes decreases over time after an attack of acute pancreatitis.CONCLUSION:Pancreatic exocrine insufficiency occurs in 40%of individuals with newly diagnosed prediabetes or diabetes mellitus after acute pancreatitis.Further studies are needed to investigate the pathogenesis of diabetes in this setting. | Stephanie L M Das James I C Kennedy Rinki Murphy Anthony R J Phillips John A Windsor Maxim S Petrov | 2014 | World Journal of Gastroenterology2014，20，45： | 9 |
| 14 | Establishing proof of concept:Platelet-rich plasma and bone marrow aspirate concentrate may improve cartilage repair following surgical treatment for osteochondral lesions of the talus显示文摘Osteochondral lesions of the talus are common injuries in the athletic patient. They present a challenging clinical problem as cartilage has a poor potential for healing. Current surgical treatments consist of reparative(microfracture) or replacement(autologous osteochondral graft) strategies and demonstrate good clinical outcomes at the short and medium term follow-up. Radiological findings and second-look arthroscopy however, indicate possible poor cartilage repair with evidence of fibrous infill and fissuring of the regenerative tissue following microfracture. Longer-term follow-up echoes these findings as it demonstrates a decline in clinical outcome. The nature of the cartilage repair that occurs for an osteochondral graft to become integrated with the native surround tissue is also of concern. Studies have shown evidence of poor cartilage integration,with chondrocyte death at the periphery of the graft, possibly causing cyst formation due to synovial fluid ingress. Biological adjuncts, in the form of platelet-rich plasma(PRP) and bone marrow aspirate concentrate(BMAC), have been investigated with regard to their potential in improving cartilage repair in both in vitro and in vitro settings. The in vitro literature indicates that these biological adjuncts may increase chondrocyte proliferation as well as synthetic capability, while limiting the catabolic effects of an inflammatory joint environment. These findings have been extrapolated to in vitro animal models, with results showing that both PRP and BMAC improve cartilage repair. The basic science literature therefore establishes the proof of concept that biological adjuncts may improve cartilage repair when used in conjunction with reparative and replacement treatment strategies for osteochondral lesions of the talus. | Niall A Smyth Christopher D Murawski Amgad M Haleem Charles P Hannon Ian Savage-Elliott John G Kennedy | 2012 | World Journal of Orthopedics2012，3，7： | 8 |
| 15 | Pure and Mg-doped self-assembled ZnO nano-particles for the enhanced photocatalytic degradation of 4-chlorophenol显示文摘A novel self-assembled pure and Mg doped ZnO nano-particles(NPs) were successfully synthesized by a simple low temperature co-precipitation method. The prepared photocatalysts were characterized by X-ray difraction, high resolution scanning electron microscopy, high resolution transmission electron microscopy, difuse reflectance spectroscopy and photoluminescence(PL) spectroscopy.The results indicated that the prepared photocatalysts showed high crystallinity with a uniform size distribution of the NPS. The degradation of cholorphenols is highly mandatory in today's scenario as they are afecting the environment adversely. Thus, the photocatalytic degradation of 4-chlorophenol(4-CP), a potent endocrine disrupting chemical in aqueous medium was investigated by both pure and Mg-doped ZnO NPs under UV-light irradiation in the present study. The influence of the Mg content on the structure,morphology, PL character and photocatalytic activity of ZnO NPs were investigated systematically. Furthermore,the efect of diferent parameters such as 4-CP concentration, photocatalyst amount, pH and UV-light wavelength on the resulting photocatalytic activity was investigated. | N.Clament Sagaya Selvam S.Narayanan L.John Kennedy J.Judith Vijaya | 2013 | Journal of Environmental Sciences2013，25，10： | 8 |
| 16 | Platelet-rich plasma increases transforming growth factor-beta1 expression at graft-host interface following autologous osteochondral transplantation in a rabbit model显示文摘AIM: To explore the effect of platelet-rich plasma on protein expression patterns of transforming growth factor-beta1(TGF-β1) in cartilage following autologous osteochondral transplantation(AOT) in a rabbit knee cartilage defect model.METHODS: Twelve New Zealand white rabbits received bilateral AOT. In each rabbit, one knee was randomized to receive an autologous platelet rich plasma(PRP) injection and the contralateral knee received saline injection. Rabbits were euthanized at 3, 6 and 12 wk post-operatively. Articular cartilage sections were stained with TGF-β1 antibody. Histological regions of interest(ROI)(left, right and center of the autologous grafts interfaces) were evaluated using Meta Morph. Percentage of chondrocytes positive for TGF-β1 was then assessed.RESULTS: Percentage of chondrocytes positive for TGF-β1 was higher in PRP treated knees for selected ROIs(left; P = 0.03, center; P = 0.05) compared to control and was also higher in the PRP group at each post-operative time point(P = 6.6 × 10^(-4), 3.1 × 10^(-4) and 7.3 × 10^(-3) for 3, 6 and 12 wk, respectively). TGF-β1 expression was higher in chondrocytes of PRP-treated knees(36% ± 29% vs 15% ± 18%)(P = 1.8 × 10^(-6)) overall for each post-operative time point and ROI. CONCLUSION: Articular cartilage of rabbits treated with AOT and PRP exhibit increased TGF-β1 expression compared to those treated with AOT and saline. Our findings suggest that adjunctive PRP may increase TGF-β1 expression, which may play a role in the chondrogenic effect of PRP in vivo. | Lorraine A Boakye Keir A Ross John M Pinski Niall A Smyth Amgad M Haleem Charles P Hannon Lisa A Fortier John G Kennedy | 2015 | World Journal of Orthopedics2015，6，11： | 7 |
| 17 | 中英两国四肢瘫患者生活满意度、生活质量及心理状况比较显示文摘目的比较中英两国四肢瘫患者康复后的生活满意度、生活质量和心理状况的异同。方法调查 44名四肢瘫患者(中、英各 2 2名 ) ,对其生活满意度、生活质量评价及焦虑和抑郁情绪的调查数据进行统计分析。结果英国组患者对职业、经济状况及家庭生活的满意度高于中国组患者 ;对伤残后生活价值、自身生存意义的认识比中国组患者积极 ,情绪稳定性也明显好于中国组患者 ;而在总体生活满意度、生活自理、空闲生活、性生活、与伙伴的关系、与朋友等人的联络方面 ,以及伤残后的生活质量评价方面 ,两组患者无显著性差异。结论要提高四肢瘫患者的生活质量 。 | 刘松怀 李建军 刘根林 Paul Kennedy | 2004 | 中国康复理论与实践2004，10，10： | 7 |
| 18 | 小孔径泡沫铝的制备及压缩性能研究显示文摘在常规熔体发泡法基础上,采用添加0.5%Mg(质量分数,下同)以降低表面张力;发泡剂400℃,6h+500℃,1h氧化预处理以协调发泡剂分散均匀性与发泡过程关系;发泡搅拌60s以破碎初始气泡等措施,成功制备出了平均孔径1.3mm、孔隙率70.5%、结构均匀的小孔径泡沫铝。泡沫铝及Al-9Si泡沫的压缩性能分析表明,随平均孔径减小,泡沫铝的屈服强度、致密化应变和能量吸收能力均明显提高,泡沫铝压缩性能随孔径减小而提高,与泡沫铝的孔结构因素及孔结构均匀性有关。 | 左孝青 Kennedy A R 王永胜 毕于顺 陆建生 周芸 | 2009 | 稀有金属材料与工程2009，38，A03： | 6 |
| 19 | ELISA快速测定小麦中硫丹及硫丹硫酸酯显示文摘研究应用酶联免疫方法,快速检测小麦中硫丹及硫丹硫酸酯。小麦经80%甲醇提取后,用PBS/T缓冲液稀释5倍后,酶联免疫方法直接测定。方法平均回收率为73.3%~88.8%,线性范围1.5μg/L^25μg/L,最低检测限0.4μg/L,变异系数<10.03%。经气相色谱/质谱联用方法验证,灵敏度、重现线和准确度均符合快速检测要求。该法具有快速、简便、低耗、易操作等特点。 | 吕潇 聂燕 陈子雷 黎秀卿 李慧冬 李瑞菊 张红 万春燕 朱端卫 Lee Nanju A Shields Ross Kennedy Ivan R | 2006 | 中国粮油学报2006，21，5： | 6 |
| 20 | 合生素治疗(长双歧杆菌/Synergy1)可促进活动性溃疡性结肠炎患者炎症消退:一项随机对照初步试验 | Furrie E. Macfarlane S. Kennedy A. 陈云茹 | 2005 | 世界核心医学期刊文摘(胃肠病学分册)2005，0，7： | 6 |
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