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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Intra-and inter-specific mitochondrial DNA sequences divergence in salmo:rainbow,steelhead,and cutthroat trouts显示文摘 | Wilson G M Thomas W K Beckenbach A T | 1985 | Can J Zool1985，，63： | 2 |
| 3 | Registration of LD00- 2817P soybean germplasm line with resistance to soybean cyst nematode from PI 437654 显示文摘 | Diets B W Cary T Thomas D | 2010 | Journal of Plant Registrations2010，4，2： | 1 |
| 4 | Post-collisional magmatism in the central East African orogen: The Maevarano suite of north Madagascm显示文摘 | Goodenough K M Thomas R J De Waele B Key R M Schofield D I Bauer W Tucker R D Kafahatelo J M Rabrimanana M Ralison A V Randriamananjma T | 2010 | Lithos2010，116，12： | 1 |
| 5 | Process Simulation in Stamping-recent Applications for Production Process Desigen显示文摘 | Thomas W Oenoki T Altan T | 2000 | Journal of Materials Processing Technology2000，98，2： | 1 |
| 6 | Predic- tions of urban volumes in single time series显示文摘 | Thomas T Weijermars W Berkum E V | 2010 | IEEE Transactions on Intelligent Transportation Systems2010，11，1： | 1 |
| 7 | No hydrostatic ,mesobeta-scale model sim- ulations of cloud ceiling and visibility for an east coast winter precipita- tion event显示文摘 | MARK T S THOMAS T W | 1999 | J Appl Meteor1999，38，4： | 1 |
| 8 | Late paleocene to eocene paleocenography of the equatorial pacific ocean: stable isotopes recorded at ocean drilling program site 865, allison guyot显示文摘 | Zachos J C Thomas E Parrow M Paul C K Kelly D C Silva I P Sliter W V Lohmann K C | 1995 | Paleoceanography1995，10，： | 1 |
| 9 | Dynamics of mitochondrial DNA evolution in animals:amplification and sequencing with conserved primers显示文摘 | Kocher T W Thomas A Meyer | 1989 | Proc Nail Acad Sci1989，86，16： | 1 |
| 10 | Dynamics of mitochondrial DNA evolution in animals: amplification and sequencing with conserved primers 显示文摘 | Kocher T D Thomas W K Meyer A | 1989 | Proc Natl Acad Sci USA1989，86，： | 1 |
| 11 | Chemical sen- sors based on amplifying fluorescent conjugated poly- mers显示文摘 | Thomas m S W Joly G D Swager T M | 2007 | Chem Rev2007，107，4： | 1 |
| 12 | Dy- namics of mitochondrial DNA evolution in mammals : Am- plification and sequencing with conserved primers 显示文摘 | KOCHER T D THOMAS W K MEYER A | 1989 | PNAS1989，86，16： | 1 |
| 13 | Quantitative Patterns of Azathio- prine Adherence after Renal Transplantation显示文摘 | Nevins T E Thomas W | 2009 | Transplan- tation2009，87，5： | 1 |
| 14 | The ionic KAl13molecule:a stepping stone to cluster assembled materials显示文摘 | ZHENG W J THOMAS O C LIPPA T P | 2006 | J Chem Phys2006，124，14： | 1 |
| 15 | Investigation of benzene oxide in bone marrow and other tissues of F344 rats following metabolism of benzene in vitro and in vivo 显示文摘 | Andrew B L Karen YO C Suramya W Thomas A M Bernard T G Stephen M R | 1998 | Chemical Research in Toxicology1998，11，4： | 1 |
| 16 | Potential stem cell marker CD44 is constitutively expressed in permanent cell lines of head and neck cancer显示文摘 | Ralph P Nadine W Thomas T | 2008 | In Vivo2008，22，1： | 1 |
| 17 | The revised structure of the peptide antibiotic esperin, established by mass spectrome- try显示文摘 | Thomas D W Ito T | 1969 | Tetrahedron1969，25，9： | 1 |
| 18 | Examining the global environmental impact of regional consumption activities-Part 1: A technical note on combining input-output and ecological footprint analysis显示文摘 | Karen T Manfred L Thomas W John B | 2007 | Ecological Economics2007，62，： | 1 |
| 19 | Chemical sensors based on amplifying fluorescent conjugated polymers显示文摘 | Thomas III S W Joly G D Swager T M | 2007 | Chem Rev2007，107，： | 1 |
| 20 | Comparison of shoot dry weight,Na+ content and δ3C value of ari-e and other semi-dwarf barley mutants under salt stress显示文摘 | Pakniyat H Handkey L L Thomas W T B | 1997 | Euphytica1997，94，： | 1 |
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