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| 1 | Targeted therapy in advanced metastatic colorectal cancer: Current concepts and perspectives显示文摘The introduction of new cytotoxic substances as well as agents that target vascular endothelial growth factor(VEGF)and epidermal growth factor receptor(EGFR)signaling has improved clinical outcome of patients withmetastatic colorectal cancer(mCRC).In this review we summarize the most relevant clinical data on VEGF and EGFR targeting regimens in mCRC.The effects of available treatment strategies for mCRC are often temporary,with resistance and disease progression developing in most patients.Thus,new treatment strategies are urgently needed.Some GI peptides including gastrin and gastrin releasing peptide,certain growth factors such as insulin-like growth factor-ⅠandⅡand neuropeptides such as growth hormone releasing hormone(GHRH)are implicated in the growth of CRC.Experimental investigations in CRC with antagonistic analogs of bombesin/gastrin-releasing peptide,GHRH,and with cytotoxic peptides that can be targeted to peptide receptors on tumors,are summarized in the second part of the review. | Florian Hohla Thomas Winder Richard Greil Ferenc G Rick Norman L Block rew V Schally | 2014 | World Journal of Gastroenterology2014，20，20： | 3 |
| 2 | Macrophage secretory products induce an inflammatory phenotype in hepatocytes显示文摘AIM:To investigate the influence of macrophages on hepatocyte phenotype and function.METHODS:Macrophages were differentiated from THP-1 monocytes via phorbol myristate acetate stimulation and the effects of monocyte or macrophageconditioned medium on HepG2 mRNA and protein expression determined.The in vivo relevance of these findings was confirmed using liver biopsies from 147 patients with hepatitis C virus(HCV)infection.RESULTS:Conditioned media from macrophages,but not monocytes,induced a transient morphological change in hepatocytes associated with upregulation of vimentin(7.8±2.5-fold,P=0.045)and transforming growth factor(TGF)-β1(2.6±0.2-fold,P<0.001)and downregulation of epithelial cadherin(1.7±0.02-fold,P=0.017)mRNA expression.Microarray analysis revealed significant upregulation of lipocalin-2(17-fold,P <0.001)and pathways associated with inflammation,and substantial downregulation of pathways related to hepatocyte function.In patients with chronic HCV,realtime polymerase chain reaction and immunohistochemistry confirmed an increase in lipocalin-2 mRNA(F0 1.0 ±0.3,F1 2.2±0.2,F2 3.0±9.3,F3/4 4.0±0.8,P= 0.003)and protein expression(F1 1.0±0.5,F2 1.3± 0.4,F3/4 3.6±0.4,P=0.014)with increasing liver injury.High performance liquid chromatography-tandem mass spectrometry analysis identified elevated levels of matrix metalloproteinase(MMP)-9 in macrophageconditioned medium,and a chemical inhibitor of MMP-9 attenuated the change in morphology and mRNA expression of TGF-β1(2.9±0.2 vs 1.04±0.1,P<0.001) in macrophage-conditioned media treated HepG2 cells.In patients with chronic HCV infection,hepatic mRNA expression of CD163(F0 1.0±0.2,F1/2 2.8±0.3,F3/4 5.3±1.0,P=0.001)and MMP-9(F0 1.0±0.4,F1/2 2.8±0.3,F3/4 4.1±0.8,P=0.011)was significantly associated with increasing stage of fibrosis.CONCLUSION:Secreted macrophage products alter the phenotype and function of hepatocytes,with increased expression of inflammatory mediators,suggesting that hepatocytes actively participate in liver injury. | Michelle Melino Victoria L Gadd Gene V Walker Richard Skoien Helen D Barrie Dinesh Jothimani Leigh Horsfall Alun Jones Matthew J Sweet Gethin P Thomas Andrew D Clouston Julie R Jonsson Elizabeth E Powell | 2012 | World Journal of Gastroenterology2012，18，15： | 3 |
| 3 | A new laboratory EUV reflectometer for large optics using a laser plasma source显示文摘 | LUDWING V L THOMAS B HERMANN M | 2003 | SPIE2003，5038，： | 2 |
| 4 | Empagliflozin alleviates podocytopathy and enhances glomerular nephrin expression in db/db diabetic mice显示文摘BACKGROUND Modern guidelines recommend sodium-glucose cotransporter-2(SGLT2)inhibitors as the preferred antihyperglycemic agents for patients with type 2 diabetes and chronic kidney disease.However,the mechanisms underlying the renal protective effect of SGLT2 inhibitors are not fully understood.structure of podocytes and nephrin expression in glomeruli in db/db diabetic mice.METHODS We treated 8-wk-old male db/db mice with EMPA(10 mg/kg/d)or vehicle for 8 wk.Age-matched male db/+mice were included as non-diabetic controls.Parameters of body composition,glycemic and lipid control,and plasma concentrations of leptin,insulin and glucagon were assessed.We evaluated renal hypertrophy as kidney weight adjusted to lean mass,renal function as plasma levels of creatinine,and albuminuria as the urinary albumin-to-creatinine ratio(UACR).Renal structures were studied by light and transmission electron microscopy with a focus on mesangial volume and podocyte structure,respectively.Glomerular nephrin and transforming growth factor beta(TGF-β)were assessed by immunohistochemistry.RESULTS Severe obesity and hyperglycemia developed in db/db mice prior to the start of the experiment;increased plasma concentrations of fructosamine,glycated albumin,cholesterol,leptin,and insulin,and elevated UACR were detected.Mesangial expansion,glomerular basement membrane thickening,and increased area of TGF-βstaining in glomeruli were revealed in vehicle-treated mice.Podocytopathy was manifested by effacement of foot processes;nephrin-positive areas in glomeruli were reduced.EMPA decreased the levels of glucose,fructosamine and glycated albumin,UACR,kidney hypertrophy,mesangial expansion,glomerular basement membrane thickening,and glomerular TGF-βstaining,alleviated podocytopathy and restored glomerular staining of nephrin.CONCLUSION These data indicate that EMPA attenuates podocytopathy in experimental diabetic kidney disease.The anti-albuminuric effect of EMPA could be attributed to mitigation of podocyte injury and enhancement of nephrin expression. | Vadim V Klimontov Anton I Korbut Iuliia S Taskaeva Nataliya P Bgatova Maksim V Dashkin Nikolai BOrlov Anna S Khotskina Evgenii L Zavyalov Thomas Klein | 2020 | World Journal of Diabetes2020，11，12： | 2 |
| 5 | Gold and trace element zonation in pyrite using a laser imaging technique: Implications for the timing of gold in orogenic and Carlin- style sediment- hosted deposits 显示文摘 | R R Large L Danyushevsky C Hollit V Maslennikov S Meffer S Gilbert S Bull R Scott P Emsbo H Thomas B Singh J Foster | 2009 | Economic Geology2009，104，5： | 1 |
| 6 | Financial benefits from JIT Adoption:Effects of Customer Concentration and Cost Structure显示文摘 | RAMJI B THOMAS J L MOHAN V | 1996 | Accounting Review1996，71，2： | 1 |
| 7 | Delay effect in models of population growth显示文摘 | Dang V G Yongwimon L Thomas I S | 2005 | J Math Appl2005，305，： | 1 |
| 8 | Thymoma with epithelial micronodules and lymphoid hyperplasia: six cases of a rare and equivocal subtype显示文摘 | Thomas De Montpréville V Zemoura L Dulmet E | 2002 | Ann Pathol2002，22，3： | 1 |
| 9 | Ganesh, Modelling and Assessment of Critical Risks in BOT Road Projects 显示文摘 | Thomas A V Satyanarayana N Kalidindi L S | 2006 | Construction Management and Economics2006，24，4： | 1 |
| 10 | Left ventricular dysfunction after long-term right ventrieular apical pacing in the young显示文摘 | TANTENGCO M V THOMAS R L KARPAWICH P P | 2001 | J Am Coll Cardiol2001，1537，： | 1 |
| 11 | Experimental observation of slow mode dispersion in photonic crystal couple-cavity waveguide显示文摘 | JAGERSKA J THOMAS N L ZABELIN V | 2009 | Optics Letters2009，34，3： | 1 |
| 12 | A meta-analysis of the effects of oral zinc in the treatment of acute and persistent diarrhea显示文摘 | Lukacik M Thomas R L Aranda J V | 2008 | Pediatrics2008，121，2： | 1 |
| 13 | Effects of spirodiclofenon reproduction in a susceptible and resistant strain of tetranychusurticae显示文摘 | Steven V P Jahanqir K Thomas V L | 2009 | Experimental & AppliedAcarology2009，47，： | 1 |
| 14 | Extended serogrouping scheme for motile, mesophilic Aeromonas spp 显示文摘 | THOMAS L V GROSS R J | 1990 | Clinical Microbiol1990，28，3： | 1 |
| 15 | Waveguide birefringence temperature sensitivity in multi-turn integrated optics current sensors显示文摘 | V Minier A B Gaillard N L Thomas | 1999 | SPIE Proc1999，3746，： | 1 |
| 16 | A review of muhiehannel indices of class separability 显示文摘 | THOMAS I L CHING N P BENNING V M | 1987 | International Journal of Remote Sensing1987，8，： | 1 |
| 17 | Circadian genomics of the chick pineal gland in vitro显示文摘 | Karaganis S P Kumar V Beremand P D Bailey M J Thomas T L Cassone V M | 2008 | BMC Genomics2008，9206，： | 1 |
| 18 | Tough Package, Strong Taste: the Influence of Packaging Design on Taste Impressions and Product Evaluations显示文摘 | BECKER L THOMAS J L ROMPAY V | 2011 | Food Quality and Preference2011，22，1： | 1 |
| 19 | Health benefits of probiotics for the elderly:a review显示文摘 | BAKER H C TRAN D N THOMAS L V | 2009 | Journal of Food Service2009，20，5： | 1 |
| 20 | Discovery of azetidinyl ketolides for the treatment of susceptible and muhidrug resistant community - acquired respiratory tract infections ~显示文摘 | Thomas V Magee Sharon L Ripp Bryan Li | 2009 | J Med Chem2009，52，： | 1 |
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