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| 1 | Role of stem cell therapies in treating chronic wounds:A systematic review显示文摘BACKGROUND The impairment of cutaneous wound healing results in chronic,non-healing wounds that are caused by altered wound environment oxygenation,tissue injury,and permissive microbial growth.Current modalities for the treatment of these wounds inadequately address the complex changes involved in chronic wound pathogenesis.Consequently,stem cell therapies have emerged as a potential therapeutic modality to promote cutaneous regeneration through trophic and paracrine activity.AIM To investigate current literature regarding use of stem cell therapies for the clinical treatment of chronic,non-healing wounds.METHODS PubMed,EMBASE,Cochrane Library,Web of Science,and Scopus were queried with combinations of the search terms“mesenchymal stem cells,”“adult stem cells,”“embryonic stem cells,”“erythroid precursor cells,”“stem cell therapies,”and“chronic wounds”in order to find relevant articles published between the years of 2000 and 2019 to review a 20-year experience.Reference lists from the articles were reviewed to identify additional pertinent articles.Retrieved manuscripts(reviews,case reports/series,retrospective/prospective studies,and clinical trials)were evaluated by the authors for their depiction of clinical stem cell therapy use.Data were extracted from the articles using a standardized collection tool.RESULTS A total of 43 articles describing the use of stem cell therapies for the treatment of chronic wounds were included in this review.While stem cell therapies have been explored in in vitro and in vivo applications in the past,recent efforts are geared towards assessing their clinical role.A review of the literature revealed that adipose-derived stem cells,bone marrow-derived stem cells,bone marrowderived mononuclear cells,epidermally-derived mesenchymal stem cells,fibroblast stem cells,keratinocyte stem cells,placental mesenchymal stem cells,and umbilical cord mesenchymal stem cells have all been employed in the treatment of chronic wounds of various etiologies.Most recently,embryonic stem cells have emerged as a novel stem cell therapy with the capacity for multifaceted germ cell layer differentiation.With the capacity for self-renewal and differentiation,stem cells can enrich existing cell populations in chronic wounds in order to overcome barriers impeding the progression of wound healing.Further,stem cell therapies can be utilized to augment cell engraftment,signaling and activity,and resultant patient outcomes.CONCLUSION Assessing observed clinical outcomes,potential for stem cell use,and relevant therapeutic challenges allows wound care stakeholders to make informed decisions regarding optimal treatment approaches for their patients’chronic wounds. | Anjali C Raghuram Roy P Yu Andrea Y Lo Cynthia J Sung Melissa Bircan Holly J Thompson Alex K Wong | 2020 | World Journal of Stem Cells2020，12，7： | 5 |
| 2 | Centrifuge modeling of transport processes for pollutants in soils显示文摘 | Arulanandan K Thompson P Y Kutter B L Meegoda N J Muraleetharan K K Yogachandran C | 1988 | Journal of Geotechnical Engineering Division American Society of Civil Engineering1988，，： | 2 |
| 3 | Potential role of fibroblast growth factor in enhancement of fracture healing显示文摘 | Radomsky M L Thompson A Y Spiro R C | 1998 | Clin Orthop1998，，355： | 2 |
| 4 | An Osteoconductive Collagen/Hyaluronate Matrix for Bone Regenerte显示文摘 | Liu L S Thompson A Y Heidaran M A | 1999 | Biomaterials1999，20，12： | 1 |
| 5 | A new system of variational inclusions with (H,r/) -monotone operators in Hilbert spaces显示文摘 | Fang Y P Huang N J Thompson H B | 2005 | Comput Math Appl2005，49，： | 1 |
| 6 | Functional expression of the intestinal peptide-proton cotransporter in Xenopus laevis oocytes显示文摘 | Thompson YG Howard EF | 1991 | J Biol Chem1991，266，： | 1 |
| 7 | The effect of superoxide dismutase on nitric oxide-mediated and electrical field-stimulated diabetic rabbit cavernosal smooth muscle relaxation显示文摘 | Khan M A Thompson C S Jeremy J Y | 2001 | BJU Int2001，87，： | 1 |
| 8 | Matrix metalloproteinase- mediated disruption of tight junction proteins in cerebral vessels is reversed by synthetic matrix metalloproteinase inhibitor in focal ischemia in rat显示文摘 | Yang Y Estrada EY Thompson JF | 2007 | J Cereb Blood Flow Metab2007，27，： | 1 |
| 9 | A visfatin promoter pllymorphism is associated with low-grade inflammation and type 2 diabetes显示文摘 | ZHANG Y Y GOTTARDO L THOMPSON R | 2006 | Obesity2006，14，12： | 1 |
| 10 | Nettrotrophins in lung health and disease显示文摘 | Prakash Y Thompson MA Meuchel L | 2010 | Expert Rev Respir Meal2010，4，3： | 1 |
| 11 | Wound healing after excimer laser keratomileusis ( photorefractive keratectomy ) in monkeys 显示文摘 | Fantes FE Hanna KD Waring GO Pouliquen Y Thompson KP Savoldelli M | 1990 | Arch Ophthal- mol1990，108，5： | 1 |
| 12 | Direct mapping of hippocampal surfaces with intrinsic shape context显示文摘 | Shi Y G Thompson P M de Zubicaray G I | | 0，，03： | 1 |
| 13 | VirusSeq: software to identify viruses and their integration sites using next-generation sequencing of human cancer tissue显示文摘 | Chen Y Yao H Thompson E | 2013 | Bioinformatics2013，29，2： | 1 |
| 14 | Glutathione defense mechanism in liver injury: Insights from animal models 显示文摘 | Chen Y Dong H Thompson D C | 2013 | Food Chem Toxicol2013，60，： | 1 |
| 15 | Fibroblast growth factor 2and transforming growth factor betal synergism in human bronchialsmooth muscle cell proliferation 显示文摘 | Bosse Y Thompson C Stankova J | 2006 | Am J Respir cell Mol Biol2006，34，6： | 1 |
| 16 | Short-term forecasting of crime 显示文摘 | Gorr W Olligschlaeger A Thompson Y | 2003 | Int J Forecasting2003，19，4： | 1 |
| 17 | Evaluation of the Reportins Verbs in Academic Papers显示文摘 | Thompson & Ye Y | 1991 | Applied Linguistics1991，，12： | 1 |
| 18 | Ecto2enzyme and signaling functions of lymphocyte CD73显示文摘 | Resta R Yamashita Y Thompson LF | 1998 | Immunol Rev1998，161，1： | 1 |
| 19 | Adhesion/cementation to zirconia and other non-silicate ceramics:where are we now?显示文摘 | Thompson J Y Stoner B R Piascik J R | 2011 | Dent Mater2011，27，1： | 1 |
| 20 | Involvement of calcium and calmodulin in membrane deterioration during senescence of pea folia显示文摘 | Leshem Y Srdhara S Thompson J E | 1984 | Plant Physiology1984，75，： | 1 |
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