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3篇 您的检索式:作者名="TIAN Caijun"
    题名 作者 年代 出处 被引量
1Risk assessment for closure of the diversion channel at the Three Gorges Project in the Yangtze River显示文摘Wang Caijun Tian Xiangrong Zhu Yonghua 2003IAHS-AISH Publication (S0144-7815)2003,281,:1
2Risk assessment for closure of the diversion channel at the Three Gorges Project in the Yangtze River显示文摘Wang Caijun Tian Xiangrong Zhu Yonghua 2003IAHS-AISH Publication2003,281,:1
3Electroacupuncture alleviates orofacial allodynia and anxiety-like behaviors by regulating synaptic plasticity of the CA1 hippocampal region in a mouse model of trigeminal neuralgia显示文摘OBJECTIVE To investigate whether electroacupuncture(EA)ameliorates abnormal trigeminal neuralgia(TN)orofacial pain and anxiety-like behavior by altering synaptic plasticity in the hippocampus CA1.METHODS A mouse infraorbital nerve transection model(pTION)of neuropathic pain was established,and EA or sham EA was used to treat ipsilateral acu⁃puncture points(GV20-Baihui and ST7-Xia⁃guan).Golgi-Cox staining and transmission elec⁃tron microscopy(TEM)were administrated to observe the changes of synaptic plasticity in the hippocampus CA1.RESULTS Stable and persistent orofacial allodynia and anxiety-like behav⁃iors induced by pT-ION were related to changes in hippocampal synaptic plasticity.Golgi stain⁃ings showed a decrease in the density of dendritic spines,especially mushroom-type dendritic spines,in hippocampal CA1 neurons of pT-ION mice.TEM results showed that the density of synapses,membrane thickness of the postsynaptic density,and length of the synaptic active zone were decreased,whereas the width of the synaptic cleft was increased in pTION mice.EA attenu⁃ated pT-ION-induced orofacial allodynia and anx⁃iety-like behaviors and effectively reversed the abnormal changes in dendritic spines and syn⁃apse of the hippocampal CA1 region.CONCLU⁃SION EA modulates synaptic plasticity of hippo⁃campal CA1 neurons,and reduces abnormal oro⁃facial pain and anxiety-like behavior,providing evidence for a TN treatment strategy.JIA Yuzhi LI Haitao ZHANG Guangming WU Hongyun ZHANG Sishuo ZHI Hongwei WANG Yahan ZHU Jingwen WANG Yifan XU Xiangqing TIAN Caijun CUI Wenqiang 2023中国药理学与毒理学杂志2023,37,S01:0
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