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| 1 | Dysfunctional stem and progenitor cells impair fracture healing with age显示文摘Successful fracture healing requires the simultaneous regeneration of both the bone and vasculature;mesenchymal stem cells (MSCs) are directed to replace the bone tissue, while endothelial progenitor cells (EPCs) form the new vasculature that supplies blood to the fracture site. In the elderly, the healing process is slowed, partly due to decreased regenerative function of these stem and progenitor cells. MSCs from older individuals are impaired with regard to cell number, proliferative capacity, ability to migrate, and osteochondrogenic differentiation potential. The proliferation, migration and function of EPCs are also compromised with advanced age. Although the reasons for cellular dysfunction with age are complex and multidimensional, reduced expression of growth factors, accumulation of oxidative damage from reactive oxygen species, and altered signaling of the Sirtuin-1 pathway are contributing factors to aging at the cellular level of both MSCs and EPCs. Because of these geriatric-specific issues, effective treatment for fracture repair may require new therapeutic techniques to restore cellular function. Some suggested directions for potential treatments include cellular therapies, pharmacological agents, treatments targeting age-related molecular mechanisms, and physical therapeutics. Advanced age is the primary risk factor for a fracture, due to the low bone mass and inferior bone quality associated with aging;a better understanding of the dysfunctional behavior of the aging cell will provide a foundation for new treatments to decrease healing time and reduce the development of complications during the extended recovery from fracture healing in the elderly. | Diane R Wagner Sonali Karnik Zachary J Gunderson Jeffery J Nielsen Alanna Fennimore Hunter J Promer Jonathan W Lowery M Terry Loghmani Philip S Low Todd O McKinley Melissa A Kacena Matthias Clauss Jiliang Li | 2019 | World Journal of Stem Cells2019，11，6： | 3 |
| 2 | Sulfate adsorption and desorption reversibility in a variety of forest soils 显示文摘 | Harrison R B Johnson D W Todd D E | 1989 | J Environ Qual1989，18，： | 2 |
| 3 | Engineering a simple, efficient code generator generator 显示文摘 | CHRISTOPER W F DAVID R H TODD A P | 1992 | ACM Letters on Programming Languages and Systems1992，1，3： | 1 |
| 4 | Selective electrodeposition of metal from simulated waste solutions 显示文摘 | Armstrong R D Todd M Atkinson J W | 1996 | Applied Electrochem1996，26，： | 1 |
| 5 | The Bowen ratio-energy balance method for estimating latent heat flux of irrigated alfalfa evaluated in a semi-arid,advective environment显示文摘 | Todd R W Evett S R Howell T A | 2000 | Agic For Meteorol2000，103，： | 1 |
| 6 | Evaporation measurements and predictions from soils under crop canopies显示文摘 | Klocke N L Martin D L Todd R W | 1990 | Transactions of the ASAE1990，33，5： | 1 |
| 7 | Tin-transition metal-carbon systems for lithium-ion battery negative electrodes显示文摘 | Todd A D W Mar R E Dahn J R | 2007 | Journal of the Electrochemical Society2007，154，6： | 1 |
| 8 | The development, testing, and application of a numerical simulator for predicting miscible flood performance显示文摘 | Todd M R Longstaff W J | 1972 | Journal of Petroleum Technology1972，24，7： | 1 |
| 9 | Soil temperature and water evaporation of small steel and plastic lysimeters replaced daily显示文摘 | Todd R W Evett S R Howell T A | 2000 | Soil Science2000，165，11： | 1 |
| 10 | Responses of spectral indices to variations in vegetation cover and soil background 显示文摘 | Todd S W Hoffer R M | 1998 | Photogrammetric engineering and remote sensing1998，64，9： | 1 |
| 11 | Using the Monte Carlo-Library Least-Squares (MCLLS) approach for the invivo XRF measurement of lead in bone显示文摘 | Guo W J Gardner R P Todd A C | 2004 | Nuclear Instruments and Methods in Physics Research A2004，516，23： | 1 |
| 12 | Evaluation of candidate vaccine approaches for mers-cov显示文摘 | Wang L Shi W Joyce M G Modjarrad K Zhang Y Leung K Lees C R Zhou T Yassine H M KanekiyoM Yang Z Y Chen X Becker M M Freeman M Vogel L Johnson J C Olinger G Todd J P Bagci U Solomon J Mollura D J Hensley L Jahrling P Deni- son M R Rao S S Subbarao K Kwong P D Mascola J R Kong W P Graham B S | 2015 | Nat Commun2015，6，： | 1 |
| 13 | Combinatorial study of tin-transition metal alloys as negative electrodes for lithiumion batteries显示文摘 | Todd A D W Mar R E Dahn J R | 2006 | J Electrochem Soc2006，153，10： | 1 |
| 14 | Scrambling properties of optical fibers and the performance of a double scambler显示文摘 | Todd R Hunter Lawrence W Ramsey | 1992 | Pubilcations of the Astronomical Society of the Pacific1992，104，682： | 1 |
| 15 | Phosphomannose isomerase:A versatile selectable marker for Arbidopsis thaliana germline transformation显示文摘 | Todd R Tague B W | | 0，，： | 1 |
| 16 | Comparison of mechanically alloyed and sputtered tin-cobalt-carbon as an anode material for lithium-ion batteries 显示文摘 | FERGUSON P P TODD A D W DAHN J R | 2008 | Electrochemistry Communications2008，10，： | 1 |
| 17 | Soil temperature and water evaporation of small steel and plastic lysimeters replaced daily 显示文摘 | Todd R W S R Evett Howell T A | 2000 | Soil Sci Soc Am J2000，165，11： | 1 |
| 18 | Evaporation measurements and predictions from soils under crop canopies显示文摘 | Klocke N L Martin D L Todd R W | 1990 | Trans of the ASAE1990，33，： | 1 |
| 19 | Detecting genomic ab- errations by fluorescence in situ hybridization with quantum dots-labeled probes显示文摘 | Jiang Z Li R Todd N W | 2007 | J Nanosci Nanotech-nol2007，7，12： | 1 |
| 20 | Mild intra operative hypothermia during surgery for intracranial aneurysm显示文摘 | TODD M M HINDMAN B J CLARKE W R | 2005 | N England J Med2005，352，： | 1 |
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