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	题名	作者	年代	出处	被引量
1	Expression of HER2 and bradykinin B_1 receptors in precursor lesions of gallbladder carcinoma显示文摘AIM:To determine the expression of HER2 and bradykinin B 1 receptors(B 1 R) in the two pathogenic models of gallbladder cancer:the metaplasia-dysplasia-carcinoma and the adenoma-carcinoma pathways.METHODS:Receptor proteins were visualized by immunohistochemistry on 5-μm sections of paraffin-embedded tissue.Expression of both receptors was studied in biopsy samples from 92 patients(6 males and 86 females;age ranging from 28 to 86 years,mean 56 years).High HER2 expression in specimens was additionally investigated by fluorescence in situ hybridiza-tion.Cell proliferation in each sample was assessed by using the Ki-67 proliferation marker.RESULTS:HER2 receptor protein was absent in adenomas and in normal gallbladder epithelium.On the contrary,there was intense staining for HER2 on the basolateral membrane of epithelial cells of intestinal metaplasia(22/24;91.7%) and carcinoma in situ(9/10;90%),the lesions that displayed a significantly high proliferation index.Protein up-regulation of HER2 in the epithelium with metaplasia or carcinoma in situ was not accompanied by HER2 gene amplification.A similar result was observed in invasive carcinomas(0/12).The B 1 R distribution pattern mirrored that of HER2 except that B 1 R was additionally observed in the adenomas.The B 1 R appeared either as cytoplasmic dots or labeling on the apical cell membrane of the cells composing the epithelia with intestinal metaplasia(24/24;100%) and carcinoma in situ(10/10;100%) and in the epithelial cells of adenomas.In contrast,both HER2(4/12;33%) and B 1 R(1/12;8.3%) showed a low expression in invasive gallbladder carcinomas.CONCLUSION:The up-regulation of HER2 and B1R in precursor lesions of gallbladder carcinoma suggests cross-talk between these two receptors that may be of importance in the modulation of cell proliferation in gallbladder carcinogenesis.	Cesar Toledo Carola E Matus Ximena Barraza Pamela Arroyo Pamela Ehrenfeld Carlos D Figueroa Kanti D Bhoola Maeva del Pozo Maria T Poblete	2012	World Journal of Gastroenterology2012，18，11：	6
2	Influence of magnetic field on physical-chemical properties of the liquid water:Insights from experimental and theoretical models 显示文摘	Toledo E J L Ramalho T C Magriotis Z M	2008	Journal of Molecular Structure2008，888，13：	1
3	Integrated driving behavior modeling 显示文摘	Toledo T Koutsopoulos H N Ben-Akiva M	2007	Transportation Research Part C2007，15，2：	1
4	Extended time-dependent mild-slope and wave-action equations for wave-bottom and wave-current interactions显示文摘	Toledo Y Hsu T W Roland A	2012	Proceedings of the Royal Society A: Mathematical Physical and Engineering Science2012，468，2137：	1
5	Driving behaviour: models and challenges 显示文摘	TOLEDO T	2007	Transport Reviews2007，27，1：	1
6	Influence oI magnetic field on physical-chemical properties of the liquid water insights from experimental and theoretical models 显示文摘	Toledo E J L Ramalho T C Magriotis Z M	2008	Journal of Molecular Structure2008，888，123：	1
7	Hydraulic conductivity of porous media at low water content显示文摘	Toledo P G Novy R A Davis H T	1990	Soil Science Society of America Journal1990，54，3：	1
8	Effects of gamma radiation on total phenolics,trypsin and tannin inhibitors in soybean grains显示文摘	De Toledo T C F Canniatti-Brazaca S G Arthur V	2007	Radiation Physics and Chemistry2007，76，：	1
9	Pore-space statistics and cap-illary pressure curves from volume- controlled porosimetry显示文摘	Toledo P G Scriven L E Davis H T	1994	SPE Formation Evaluation1994，9，1：	1
10	Isolation of a phospholipid fraction from inedible egg 显示文摘	Shah A Akoh C C Toledo R T	2004	J Supercrit Fluids2004，30，：	1
11	Relationship between chopping temperature and fat and water binding in comminuted meat batters 显示文摘	Brown D D Toledo R T	1975	Journal of Food Science1975，40，：	1
12	Investigating Path-based Solution Algorithms to the Stochastic User Equilibri-um Problem 显示文摘	BEKHOR S TOLEDO T	2005	Transportation Research Part B2005，39，3：	1
13	Intrafamilial Transmission of Driving Behavior显示文摘	Prato CG Lotan T Toledo T		0，，：	1
14	Influence of magnetic field on physical-chemical properties of the liquid water:Insights from experimental and theoretical models显示文摘	Toledo E J L Ramalho T C Magriotis Z M	2008	Molecular Structure2008，888，7：	1
15	Effects of Choice Set Size and Route Choice Models on Path- based Traffic Assignment 显示文摘	BEKHOR S TOLEDO T PRASHKER J N	2008	Transportmetrica2008，4，2：	1
16	Metmyoglobin reduction in beef as affected by aerobic,anaerobic and c arbon monoxide containing environments显示文摘	Lanier T C Carpenter J A Toledo R T	1978	J Food Science1978，43，：	1
17	Proteomic analysis of banana fruit reveals proteins that are differentially accunulated during ripening 显示文摘	Toledo T T Nogueira S B Cordenunsi B R	2012	Postharvest Biology and Technology2012，70，：	1
18	31p NMR analysis of chicken breast meat vacuum tumbled with NaCl various phosphates显示文摘	Rongrong Li William L Kerr Romeo T Toledo	2001	J Sci Food Agri2001，81，：	1
19	Optimization of vapor induced puffing in apple dehydration 显示文摘	Torreggiani D Toledo D T Bertolo G	1995	Journal of Food Science1995，60，18：	1
20	A Lagrangian- based heuristic for the capacitated lot-sizing problem in parallel machines 显示文摘	Toledo F M B T Armentano V A	2007	European Journal of Opera- tional Research2007，175，2：	1

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