|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Ion-pairing HPLC methods to determine EDTA and DTPA in small molecule and biological pharmaceutical formulations显示文摘Ion-pairing high-performance liquid chromatography–ultraviolet(HPLC–UV) methods were developed to determine two commonly used chelating agents,ethylenediaminetetraacetic acid(EDTA) in Abilifys(a small molecule drug with aripiprazole as the active pharmaceutical ingredient) oral solution and diethylenetriaminepentaacetic acid(DTPA) in Yervoys(a monoclonal antibody drug with ipilimumab as the active pharmaceutical ingredient) intravenous formulation.Since the analytes,EDTA and DTPA,do not contain chromophores,transition metal ions(Cu^(2+) t,Fe^(3+) t) which generate highly stable metallocomplexes with the chelating agents were added into the sample preparation to enhance UV detection.The use of metallocomplexes with ion-pairing chromatography provides the ability to achieve the desired sensitivity and selectivity in the development of the method.Specifically,the sample preparation involving metallocomplex formation allowed sensitive UV detection.Copper was utilized for the determination of EDTA and iron was utilized for the determination of DTPA.In the case of EDTA,a gradient mobile phase separated the components of the formulation from the analyte.In the method for DTPA,the active drug substance,ipilimumab,was eluted in the void.In addition,the optimization of the concentration of the ion-pairing reagent was discussed as a means of enhancing the retention of the aminopolycarboxylic acids(APCAs) including EDTA and DTPA and the specificity of the method.The analytical method development was designed based on the chromatographic properties of the analytes,the nature of the sample matrix and the intended purpose of the method.Validation data were presented for the two methods.Finally,both methods were successfully utilized in determining the fate of the chelates. | George Wang Frank P. Tomasella | 2016 | Journal of Pharmaceutical Analysis2016，6，3： | 4 |
| 2 | Modulation of the cutoff wavelength in the spectra for solar selective absorbing coating based on high-entropy films显示文摘This paper demonstrates an intrinsic modulation of the cutoff wavelength in the spectra for solar selective absorbing coating based on high-entropy films.The(NiCuCrFeSi)N((NCCFS)N)films were deposited by a magnetron sputtering system.Rutherford backscattering spectroscopy analysis confirms the uniform composition and good homogeneity of these high-entropy films.The real and imaginary parts of the permittivity for the(NCCFS)N material are calculated on the basis of the reflectance spectral fitting results.A redshift cutoff wavelength of the reflectance spectrum with increasing nitrogen gas flow rate exists because of the different levels of dispersion when changing nitrogen content.To realize significant solar absorption,the film surface was reconstituted to match its impedance with air by designing a pyramid nanostructure metasurface.Compared with the absorptance of the as-deposited films,the designed metasurface obtains a significant improvement in solar absorption with the absorptance increasing from 0.74 to 0.99.The metasurfaces also show low mid-infrared emissions with thermal emittance that can be as low as 0.06.These results demonstrate a new idea in the design of solar selective absorbing surface with controllable absorptance and low infrared emission for high-efficiency photo-thermal conversion. | Ping Song Cong Wang Jie Ren Ying Sun Yong Zhang Angélique Bousquet Thierry Sauvage Eric Tomasella | 2020 | International Journal of Minerals,Metallurgy and Materials2020，27，10： | 2 |
| 3 | A receptor interacting protein 1(RIP1)-independent necrotic death under the control of protein phosphatase PP2A that involves the reorganization of actin cytoskeleton and the action of cofilin-1显示文摘 | Tomasella A Blangy A Brancolini C | 2014 | J Biol Chem2014，289，25： | 1 |
| 4 | Effect of selected alcohols on chiral recognitionvia cyclodextrin inclusion complexation显示文摘 | TOMASELLA F P ZUTING P CLINE LOVE L J | 1992 | Supramolecular Chemistry1992，1，： | 1 |
| 5 | Marked differences between van Genuchten soil water-retention parameters for temperate and tropical soils : a new water-retention pedo-transfer functions developed for tropical soils 显示文摘 | Hodnett M G Tomasella J | 2002 | Geoderma2002，108，3： | 1 |
| 6 | Biodegradability of diodiesel blends显示文摘 | Mariano Adriano Pinto Tomasella Richard Clay | | 0，，09： | 1 |
| 7 | The drought of 2010 in the context of historical draughts in the Amazon region显示文摘 | MARENGO J A TOMASELLA J ALVES L M | | 0，，12： | 1 |
| 8 | a-C:H thin films deposited by radio-frequency plasma:influence of gas composition on structure,optical properties and stress levels显示文摘 | TOMASELLA E MEUNIERB C MIKHAILOV S | 2001 | Surface and Coatings Technology2001，141，： | 1 |
| 9 | Effects of organic modifier and temperature on micellar liquid chromatography显示文摘 | Tomasella FP Fett J Cline Love LJ | 1991 | Anal Chem1991，63，5： | 1 |
| 10 | SiO Nr thin films deposited by reactive sputtering: process study and structural characterisation显示文摘 | Rebib F Tomasella E Dubois M | 2007 | Thin Solid Films2007，515，78： | 1 |
| 11 | Aerobic Biodegradation of Butanol and Gasoline Blends显示文摘 | Mariano A P Tomasella R C Martino CD | 2009 | Biomass and Bioenergy2009，33，9： | 1 |
| 12 | Structrural and optical studies of ZnO thin films deposited by rf magnetron sputtering:influence of annealing显示文摘 | Moustaghfir A Tomasella E Amor S B | 2003 | Surf and coat Technol2003，，： | 1 |
| 13 | Drug interactions with potential rubber closure extractables identification of thiol-di- sulfide exchange reaction products of captopril and thiurams显示文摘 | CORREDOR C TOMASELLA FP YOUNG J | 2009 | J Chromatography A2009，1216，1： | 1 |
| 14 | Characterization of Sol - gel Derived Scintillating LuBO3 Films Doped with Rare Earth Ions 显示文摘 | MANSUY C TOMASELLA E MAHIOU R | 2006 | Thin Solid Films2006，515，： | 1 |
| 15 | Interception water-partitioning dynamics for a pristine rainforest in central Amazonia:marked differences between normal and dry years显示文摘 | CUARTAS L TOMASELLA J NOBRE A | 2007 | Agricultural and Forest Meteorology2007，145，12： | 1 |
| 16 | Lumbar functional instability: a critical appraisal the literature 显示文摘 | aDesmoulins C Distree V Tomasella M | 2007 | Medecine Physique2007，50，： | 1 |
| 17 | Influence of an nealing temperature on the properties of ZnO thin films deposited by thermal evaporation显示文摘 | Bouhssira N Abed S Tomasella E | 2006 | Appl Surf Sci2006，252，15： | 1 |
| 18 | Interception water-partitioning dynamics for a pristine rainforest in Central Amazonia:Marked differences between normal and dry years显示文摘 | Cuartas L A Tomasella J Nobere A D | 2007 | Agricultural and Forest Meteorology2007，145，： | 1 |
| 19 | Lumbar functional in-stability: a critical appraisal of the literature显示文摘 | Demoulin C Distree V Tomasella M | 2007 | Ann Readapt MedPhys2007，50，8： | 1 |
| 20 | A computational estimation of cyclic material properties using artificial neural networks显示文摘 | A Tomasella C el Dsoki H Hanselka | 2011 | Procedia Engineering2011，10，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员