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| 1 | 基于IMRT时代的第八版AJCC/UICC鼻咽癌临床分期建议显示文摘目的准确的分期系统对癌症的治疗至关重要。随着癌症分期和治疗方法的演变,需要不断评价分期的适用性和改进性。方法基于第7版AJCC/UICC分期回顾性分析香港和中国大陆2个肿瘤中心收治的1609例接受调强放射治疗的首诊无转移鼻咽癌患者临床资料,所有患者治疗前均行核磁共振分期评估。结果无其他T3、T4期解剖结构受侵患者中,伴有咀嚼肌间隙(翼内肌和/或翼外肌)侵犯、椎前肌侵犯及咽旁间隙侵犯的三组患者之间0s相近。伴广泛软组织(上述侵犯结构以外的软组织)受侵患者OS与伴有颅内侵犯或颅神经侵犯相似。仅2%患者锁骨上窝以上淋巴结转移者直径〉6cm,其0s率与下颈淋巴结转移者类似。用下颈(环状软骨尾侧缘水平以下)代替锁骨上窝并不影响N分期之间的风险差异性。采用推荐的T、N分期,T。N。、T。N,期0s相近。结论经AJCC/UICC分期筹备委员会审阅后,建议第8版分期应将翼内肌/翼外肌从T。降到T:期,增加椎前肌为L期,用下颈取代锁骨上窝,将淋巴结最大直径〉6cm合并归为N,期,将T。、N,期统一归为Ⅳ。期。这些改变不仅使得相邻分期间风险差异性更好,而且使得临床实践性与全球适用性之间达到最佳平衡。 | 潘建基 Wai Tong Ng 宗井凤 Lucy L.K.Chan Brian O' Sullivan 林少俊 Henry C.K.Sze 陈韵彬 Horace C.W.Choi 郭巧娟 Wai Kuen Kan 肖友平 Xu Wei Quynh Thu Le Christine M.Glastonbury A.Dimtrios Colevas Randal S.Weber Jatin P.Shah Anne W.M.Lee | 2016 | 中华放射肿瘤学杂志2016，25，3： | 65 |
| 2 | Effect of intestinal ischemia-reperfusion on expressions of endogenous basic fibroblast growth factor and transforming growth factor β in lung and its relation with lung repair显示文摘AIM To study the changes of endogenoustransforming growth factor β(TGFβ)and basicfibroblast growth factor(bFGF)in lung followingintestinal ischemia and reperfusion injury andtheir effects on lung injury and repair.METHODS Sixty Wistar rats were divided intofive groups,which underwent sham-operation,ischemia(45 minutes),and reperfusion(6,24and 48 hours,respectively)after ischemia(45minutes).Immunohistochemical method wasused to observe the localization and amounts ofboth growth factors.RESULTS Positive signals of both growthfactors could be found in normal lung,mainly inalveolar cells and endothelial cells of vein.Afterischemia and reperfusion insult,expressions ofboth growth factors were increased and theiramounts at 6 hours were larger than those ofnormal control or of 24 and 48 hours after insult.CONCLUSION The endogenous bFGF and TGF βexpression appears to be up-regulated in thelung following intestinal ischemia andreperfusion,suggesting that both growth factorsmay be involved in the process of lung injury andrepair. | Xiao Bing Fu Yin Hui Yang Tong Zhu Sun Xiao Man Gu Li Xian Jiang Xiao Oing Sun Zhi Yong Sheng Research Laboratory,304th Hospital of PLA,Beijing 100037,China | 2000 | World Journal of Gastroenterology2000，6，3： | 21 |
| 3 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 4 | A process for manufacturing Cu-Fe alloy C194-ESH with high electrical conductivity and excellent heat-resistance 显示文摘 | Noriyuki N Tong C Makoto O | 1999 | Hitachi Cable Review1999，18，： | 1 |
| 5 | Cyv61 suppresses the growth of non-small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway 显示文摘 | Tong X O' Kelly J Xie D | 2004 | Oncogene2004，23，28： | 1 |
| 6 | Effect of organic manure and chemical fertilizer on nitrogen uptake and nitrate leaching in a Eum-orthic anthrosols profile显示文摘 | Tong Y A Emteryd O Lü D Q | | 0，，03： | 1 |
| 7 | An essential function for Nijmegen Breakage Syndrome gene (NBS1) and DNA damage response in the prevention of ataxia and cerebellar defects显示文摘 | Frappart P O Tong W M Demuth I | 2005 | Nat Med2005，11，5： | 1 |
| 8 | Estimation of time-dependent origin-destination matrices for transit network显示文摘 | WONG S C TONG C O | 1998 | Transportation Research B1998，32，1： | 1 |
| 9 | A Sched-ule-based Dynamic Transit Network Model-Recent Advances and Prospective Future Research显示文摘 | TONG C O WONG S C POON M H | 2001 | Journal of Advanced Transportation2001，35，2： | 1 |
| 10 | Cyr61 suppresses the growth of non- small-cell lung cancer cells via the beta-catenin-c-myc-p53 pathway显示文摘 | Tong X O' Kelly J Xie D | 2004 | Oncogene2004，23，28： | 1 |
| 11 | Estimation of time-dependent origin-destination matrices for transit Network 显示文摘 | Wong S C Tong C O | 1998 | Transportation Research B1998，32，1： | 1 |
| 12 | General strategy for making CO2-switchable polymers 显示文摘 | Han D H Tong X Boissire O | 2012 | ACS Macro Lett2012，1，1： | 1 |
| 13 | An essential function for Nijmegen Breakage Syndrome gene (NBS1) and DNA damage response in the prevention of ataxia and cerebellar defects 显示文摘 | Frappart P O Tong W M Demuth I | 2005 | Nat Med2005，11，5： | 1 |
| 14 | Kinetics of nitrobenzene hydrogenation using a gel entrapped palladium catalyst显示文摘 | TONG S B O′DRISCOLL K F REMPEL G L | 2009 | Can J Chem Eng2009，56，3： | 1 |
| 15 | Changes of pan evaporation and reference evapotranspiration in the Yangtze River Basin显示文摘 | WANG Yan-jun JIANG Tong BOTHE O | 2007 | Theoretical and Apploied Climatology2007，90，： | 1 |
| 16 | Study and Imple-mentation of a Decision Support System for Urban Mass Transit Service Planning显示文摘 | TAN M C TONG C O XU J M | 2004 | Journal of In-formation Technology Management2004，15，1： | 1 |
| 17 | Serum cardiac troponin response in adolescents playing basketball显示文摘 | Nie J Tong TK Shi O | 2008 | International Journal of Sports Medicine2008，，： | 1 |
| 18 | A dynamic schedule- based model for congested transit networks 显示文摘 | Poon M H Wong S C Tong C O | 2004 | Trans- portation Research Part B : Methodological2004，38，4： | 1 |
| 19 | A new survey methodology for the annual traffic census in Hong Kong 显示文摘 | TONG C O HUNG W T LAM W H K LO H K LO H P WONG S C YANG H | 2003 | Traffic Engineering and Control2003，44，： | 1 |
| 20 | Multi-frequency EIT system with radially symmetric architecture: KHU Markl 显示文摘 | TONG I O EUNG J W HOLDER D S | 2007 | Physiological Measurement2007，28，7： | 1 |
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