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| 1 | Axial strain enhances osteotomy repair with a concomitant increase in connexin43 expression显示文摘The mechanical environment is known to influence fracture healing. We speculated that connexin43(Cx43) gap junctions, which impact skeletal homeostasis, fracture healing and the osteogenic response to mechanical load,may play a role in mediating the response of the healing bone to mechanical strain. Here, we used an established rat fracture model, which uses a 2 mm osteotomy gap stabilized by an external fixator, to examine the impact of various cyclical axial loading protocols(2%, 10%, and 30% strain) on osteotomy healing. We examined the presence of Cx43 in the osteotomy-healing environment and assessed how mechanical strain modulates Cx43 expression patterns in the callus. We demonstrated that increased cyclical axial strain results in increased radiographic and histologic bone formation. In addition, we show by immunohistochemistry that Cx43 is abundantly expressed in the healing callus, with the expression most robust in samples exposed to increased cyclical axial strain. These data are consistent with the concept that an increase in Cx43 expression by mechanical load may be part of the mechanisms by which mechanical forces enhances fracture healing. | Rishi R Gupta Hyunchul Kim Yu-Kwan Chan Carla Hebert Leah Gitajn David J Yoo Robert V O’Toole Adam H Hsieh Joseph P Stains | 2015 | Bone Research2015，3，2： | 2 |
| 2 | Dysregulation of Hedgehog,Wnt and Notch signallingpathways in breast cancer显示文摘 | Zardawi S J O’Toole S A Sutherland R L | 2009 | Histol Histopathol2009，24，38： | 1 |
| 3 | A global movement toward an ecosystem approach to management of marine resources显示文摘 | Sherman K Sissenwine M Christensen V Duda A Hempel G Ibe C Levin S Liuch-Belda D Matishov G McGlade J O'Toole M Switzinger S Serra R Skjoldat H-R Tang Q Thulin J Vandeweerd V Zwanenburg K | | 0，，： | 1 |
| 4 | Perioperative nu tritional support and malnutrition in infants and children with congenital heart disease显示文摘 | Toole B J Toole L E Kyle U G | 2014 | Congenit Heart Dis2014，9，1： | 1 |
| 5 | Inheritance ofroot characters and their relations to drought resistance in rice 显示文摘 | Ekanayake I J Toole J C 0 G arrity D P’Masajc T M | 1985 | Crop Science1985，25，6： | 1 |
| 6 | Release of early human hematopoietic progenitors from quiescence by antisense transforming growth factor beta 1 of Rb oligonucleotides 显示文摘 | Hatzfeld J Li ML Brown EL Sookdeo H Levesque JP O′Toole T | 1991 | JExp Med1991，174，4： | 1 |
| 7 | FRVT 2006 and ICE 2006 large-scale ex- perimental results显示文摘 | Phillips P J Scruggs T O'Toole A Flynn P J Bowyer K W Sehott C Sharpe M | 2010 | IEEE Transactions on Pattern Analysis and Machine Intelligence2010，32，5： | 1 |
| 8 | Studies directed at the use of a parallel synthesis matrix to increase through put in an in vivo assay显示文摘 | Freeman J Toole DO | 2000 | J Med Chem2000，43，： | 1 |
| 9 | A video database of moving faces and people显示文摘 | O'TOOLE A J HARMS J SNOW S L | 2005 | IEEE Transactions on Pattern Analysis and Machine Intelligence2005，27，5： | 1 |
| 10 | Photolysis and the dirnethylsulfide (DMS) summer paradox in the Sargasso Sea显示文摘 | TOOLED A KIEBER D J KIENE R P | 2003 | Lim- nology and Oceanography2003，48，3： | 1 |
| 11 | Visualisation of zebrafish infection by GFP-labelled Vibrio anguillarum显示文摘 | O'TOOLE R VON H J ROSQVIST R | 2004 | Microb Pathog2004，37，1： | 1 |
| 12 | Responses of seven diverse rice cultivars to water deficits I · Stress development, canopy temperature, leaf rolling and growth显示文摘 | Turner N C O’Toole J C Cruz R T | 1986 | Field Crops Research1986，13，： | 1 |
| 13 | Flow cytometric determination of residual white hlood cell levels in preserved samples from leukoreduced blood products 显示文摘 | Palmer DS Birch P O'Toole J | 2008 | Transfusion2008，48，1： | 1 |
| 14 | Selection for reproductive stage drought avoidance in rice using infrared thermometry显示文摘 | Garrity D P O Toole J C | 1995 | Agron J1995，87，： | 1 |
| 15 | Clinical pharmacokinetics of adefovir in human immunodeficiency virus type 1-infected patients显示文摘 | Cundy KC Barditch-Crovo P Walker RE Collier AC Ebeling D Toole J | 1995 | Antimicrob Agents Chemother1995，39，： | 1 |
| 16 | Differential autonomiccontrol of SAN and AVN regions of the canine heart:structure and function显示文摘 | Randall W C Ardell J L O'Toole M F | 1988 | Prog Clin Biol Res1988，275，： | 1 |
| 17 | Alternative water sources andendotoxin显示文摘 | O'Toole J Sinclair M Jeavons T | 2008 | Water Sci Technol2008，58，3： | 1 |
| 18 | Theoretical,statistical,and practical perspectives on pattern-based classification approaches to the analysis of functional neuroimaging data显示文摘 | O’Toole A J Jiang F Abdi H | 2007 | Journal of cognitive neuroscience2007，19，11： | 1 |
| 19 | The bactericidal/permeability-increasing protein (BPI) is present in specific guanules of human eosinophils显示文摘 | Calafat J Janssen H Tool A | 1998 | Blood1998，91，： | 1 |
| 20 | Networking in the Penumbra:Public Manage-ment,Cooptative Links,and Distributional Consequences显示文摘 | O’Toole Meier K J | 2006 | In-ternational Public Management Journal2006，9，4： | 1 |
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