|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Prognostic roles of preoperative α-fetoprotein and des-γ-carboxy prothrombin in hepatocellular carcinoma patients显示文摘AIM:To clarify the utility of using des-γ-carboxy prothrombin(DCP)andα-fetoprotein(AFP)levels to predict the prognosis of hepatocellular carcinoma(HCC)in patients with hepatitis B virus(HBV)and the hepatitis C virus(HCV)infections.METHODS:A total of 205 patients with HCC(105patients with HBV infection 100 patients with HCV infection)who underwent primary hepatectomy between January 2004 and May 2012 were enrolled retrospectively.Preoperative AFP and DCP levels were used to create interactive dot diagrams to predict recurrence within 2 years after hepatectomy,and cutoff levels were calculated.Patients in the HBV and HCV groups were classified into three groups:a group with low AFP and DCP levels(LL group),a group in which one of the two parameters was high and the other was low(HL group),and a group with high AFP and DCP levels(HH group).Liver function parameters,the postoperative recurrence-free survival rate,and postoperative overall survival were compared between groups.The survival curves were compared by logrank test using the Kaplan-Meier method.Multivariate analysis using a Cox forward stepwise logistic regression model was conducted for a prognosis.RESULTS:The preoperative AFP cutoff levels for recurrence within 2 years after hepatectomy in the HBV and HCV groups were 529.8 ng/m L and 60 m AU/m L,respectively;for preoperative DCP levels,the cutoff levels were 21.0 ng/m L in the HBV group and 67 m AU/m L in the HCV group.The HBV group was significantly different from the other groups in terms of vascular invasion,major hepatectomy,volume of intraoperative blood loss,and surgical duration.Significant differences were found between the LL group,the HL group,and the HH group in terms of both mean disease-free survival time(MDFST)and mean overall survival time(MOST):64.81±7.47 vs 36.63±7.62 vs 18.98±6.17mo(P=0.001)and 85.30±6.55 vs 59.44±7.87 vs46.57±11.20 mo(P=0.018).In contrast,the HCV group exhibited a significant difference in tumor size,vascular invasion,volume of intraoperative blood loss,and surgical duration;however,no significant difference was observed between the three groups in liver function parameters except for albumin levels.In the LL group,the HL group,and the HH group,the MDFST was 50.09±5.90,31.01±7.21,and 14.81±3.08 mo(log-rank test,P<0.001),respectively,and the MOST was 79.45±8.30,58.82±7.56,and 32.87±6.31 mo(log-rank test,P<0.001),respectively.CONCLUSION:In the HBV group,the prognosis was poor when either AFP or DCP levels were high.In the HCV group,the prognosis was good when either or both levels were low;however,the prognosis was poor when both levels were high.High levels of both AFP and DCP were an independent risk factor associated with tumor recurrence in the HBV and HCV groups.The relationship between tumor marker levels and prognosis was characteristic to the type of viral hepatitis. | Makoto Meguro Toru Mizuguchi Toshihiko Nishidate Kenji Okita Masayuki Ishii Shigenori Ota Tomomi Ueki Emi Akizuki Koichi Hirata | 2015 | World Journal of Gastroenterology2015，21，16： | 16 |
| 2 | Thermal Diffusivities of Continuous Casting Mold Fluxes forSteel in the Glassy and Crystalline States 显示文摘 | Hiroyuki Shibata Toshihiko Emi Yoshio Waseda | 1996 | Tetsu-to-Hagane1996，82，6： | 1 |
| 3 | Characteristics of Agglomeration of Various Inclusion Particles on Molten SteelSurface显示文摘 | Hongbin YIN Hiroyuki SHIBATA Toshihiko EMI | 1997 | ISIJ Int1997，37，10： | 1 |
| 4 | 'In-situ' Observation of Collision, Agglomeration and Cluster Formation of Alumina Inclusion Particles on Steel Melts显示文摘 | Hongbin YIN Hiroyuki SHIBATA Toshihiko EMI | 1997 | ISIJ Int1997，37，10： | 1 |
| 5 | Development of Steels Resistant to Hydrogen Induced Cracking in Wet Hydrogen Sulfide Environment 显示文摘 | Nakai Yoichi Kurahashi Hayao Emi Toshihiko | 1979 | Transactions ISIJ1979，，7： | 1 |
| 6 | A new uniform protocol of combined corticosteroid injections and ointment application reduces recurrence rates after surgical keloid/hypertrophic scar excision显示文摘 | Hayashi Toshihiko Furukawa Hiroshi Oyama Akihiko Funayama Emi Saito Akira Murao Naoki Yamamoto Yuhei | | 0，，： | 1 |
| 7 | Mechanism of sulfide shape control in continuously cast HSLA steel slabs treated with Ca and/or RE显示文摘 | Dsamu Haida Toshihiko EMI | 1980 | Tetsu-to-hagane1980，，03： | 1 |
| 8 | 'In situ' observation of collision agglomeration and cluster formation of alumina inclusion particles on steel melts显示文摘 | Yin Hongbin Hiroyuki Shibata Toshihiko Emi et al | 1997 | ISIJ Int1997，37，10： | 1 |
| 9 | Melt flow characterization in continuous casting tundishes显示文摘 | Sahai Y Toshihiko EMI | 1996 | ISIJ Intenrational1996，36，4： | 1 |
| 10 | Characteristics of agglomeration of various inclusion particles on molten steel surface显示文摘 | Yin Hongbin Hiroyuki Shibata Toshihiko Emi et al | 1997 | ISIJ Int1997，37，10： | 1 |
| 11 | Melt flow charactedzation in continuous casting tundishes显示文摘 | Sahai Y Toshihiko EMI | 1996 | ISIJ Intenrational1996，36，4： | 1 |
| 12 | Melt flow charac- terization in continuous casting tundishes 显示文摘 | Yogeshwar Sahai Toshihiko Emi | 1996 | ISIJ international1996，36，6： | 1 |
| 13 | Melt Flow Characterization in Continuous Casting Stundishes显示文摘 | Yogeshwar SAHAI Toshihiko EMI | 1996 | ISIJ Int1996，36，6： | 1 |
| 14 | Criteria for water modeling of melt flow and inclusion removal in continuous casting tundishes显示文摘 | Sahai Yogeshwar Emi Toshihiko | 2010 | ISIJ International2010，，8： | 1 |
| 15 | Thermal mold for resistance at the interface between mold flux film and continuous casting of steels显示文摘 | Jung wook CHO Hiroyuki SHIBATA Toshihiko EMI | 1998 | ISIJ In- ternational1998，38，5： | 1 |
| 16 | Melt Flow Characterization in Continuous Casting Tundishes显示文摘 | Yogeshwar Sahal Toshihiko Emi | 1996 | ISIJ International1996，36，6： | 1 |
| 17 | lnsitu real time observation of planar to cellular and cellular to dendritic transition of crystals growing in Fe-C alloy melts 显示文摘 | Hiroshi Chikama Hiroyuki Shibata Toshihiko Emi | 1996 | JIM Materials Transactions1996，37，4： | 1 |
| 18 | Melt flow characterization in continuous casting tundishes显示文摘 | Yogeshwar Sahai Toshihiko Emi | 1996 | ISIJ International1996，36，6： | 1 |
| 19 | High-speed continuous cast- ing of peritectic carbon steels显示文摘 | Toshihiko Emi Hasse Fredriksson | 2005 | Materials Science and Engineer- ingA2005，，： | 1 |
| 20 | High-Speed Continuous Casting of Peritectic Carbon Steels显示文摘 | Toshihiko Emi Hasse Fredriksson | 2005 | Materials Science and Engineering A2005，，413： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员