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| 1 | Relative validity of a semi-quantitative food frequency questionnaire versus 3 day weighed diet records in middle-aged inhabitants in chaoshan area,china显示文摘 | Ke L Toshiro T Feng YS | 2005 | Asia Pac J Cancer Prev2005，6，： | 1 |
| 2 | Preparation and character- ization of novel bioactive peptides responsible for angiotensin I converting enzyme inhibition from wheat germ 显示文摘 | Toshiro M Chun H L Yutaka O | 1999 | Journal of Peptide science1999，，5： | 1 |
| 3 | Enchancement of angiogenesis by the implantation of self bone marrow cells in a rat ischemic heart model显示文摘 | TOSHIRO K KIMIKAZU H TAO S L | 2003 | J Surg Res2003，89，： | 1 |
| 4 | Therapeutic effects of SNMC at different doses on chronic hepatitis and liver cirrhosis显示文摘 | Shiro L Toshiro T Takashi M | 2001 | Hepatology Res2001，19，7： | 1 |
| 5 | Therapeutic effects of strong neo-minophagen C at different doses on chronic hepatitis and liver cirrhosis显示文摘 | Shiro L Toshiro T Takashi M | 2001 | Hepatology Research2001，19，1： | 1 |
| 6 | Therapeutic effects of strong neominophagen C at different doses on chronic hepatitis and liver cirrhosis显示文摘 | Toshiro T Takashi M | 2001 | Hepatology Research2001，19，1： | 1 |
| 7 | A novel precision positioning table utilizing impact force of spring-mounted piezoelectric actuator-part Ⅰ: experimental design and results 显示文摘 | YUNG T L TOSHIRO H RONG F F | 2003 | Precision Engineering2003，27，1： | 1 |
| 8 | Human galectin-9 potently enhances SARS-CoV-2 replication and inflammation in airway epithelial cells显示文摘The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has caused a global economic and health crisis. Recently, plasma levels of galectin-9 (Gal-9), a β-galactoside-binding lectin involved in immune regulation and viral immunopathogenesis, were reported to be elevated in the setting of severe COVID-19 disease. However, the impact of Gal-9 on SARS-CoV-2 infection and immunopathology remained to be elucidated. In this study, we demonstrate that Gal-9 treatment potently enhances SARS-CoV-2 replication in human airway epithelial cells (AECs), including immortalized AECs and primary AECs cultured at the air–liquid interface. Gal-9–glycan interactions promote SARS-CoV-2 attachment and entry into AECs in an angiotensin-converting enzyme 2 (ACE2)-dependent manner, enhancing the binding of the viral spike protein to ACE2. Transcriptomic analysis revealed that Gal-9 and SARS-CoV-2 infection synergistically induced the expression of key pro-inflammatory programs in AECs, including the IL-6, IL-8, IL-17, EIF2, and TNFα signaling pathways. Our findings suggest that manipulation of Gal-9 should be explored as a therapeutic strategy for SARS-CoV-2 infection. | Li Du Mohamed S.Bouzidi Akshay Gala Fred Deiter Jean-Noël Billaud Stephen T.Yeung Prerna Dabral Jing Jin Graham Simmons Zain Y.Dossani Toshiro Niki Lishomwa C.Ndhlovu John R.Greenland Satish K.Pillai | 2023 | Journal of Molecular Cell Biology2023，15，4： | 1 |
| 9 | Preparation and characterization of novel bioactive peptides responsible for angiotensin I-converting enzyme inhibition from wheat germ显示文摘 | Toshiro M Chun-hui L Yutaka O | 1999 | Journal of Peptide Science1999，5，： | 1 |
| 10 | Blast wave characteristics under laser-driven in-tube accelerator operation conditions显示文摘 | Yu X L Toshiro O Sukyum K | 2005 | Science and Technology of Energetic Materials2005，66，2： | 1 |
| 11 | Therapeutic effects of strong neominophagen C at different doses on chronic hepatitis and liver cirrhosis 显示文摘 | Shiro L Toshiro T Takashi M | 2001 | Hepatology Research2001，19，1： | 1 |
| 12 | Molecular characteriza- tion, tissue distribution patterns and nutritional regulation of IGFBP- 1,-2,-3 and -5 in yellowtail, Seriola quinqueradiata 显示文摘 | Fiona L P Haruhisa F Toshiro M | 2009 | General and Comparative Endocrinology2009，161，3： | 1 |
| 13 | Contribution of surface conductivity to the current forms of partial dis- charges in voids 显示文摘 | KAI W TOSHIRO L TAKEYOSHI K | 2005 | IEEE Transactions on Dielectrics and Electrical Insulation2005，12，6： | 1 |
| 14 | DSC investigation of the states of water in poly(vinyl-alcohol) membranes显示文摘 | Akon H Toshiro L | 1985 | Polymer1985，26，8： | 1 |
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