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| 1 | Neuroretinal hypoxic signaling in a new preclinical murine model for proliferative diabetic retinopathy显示文摘Diabetic retinopathy(DR)affects approximately one-third of diabetic patients and,if left untreated,progresses to proliferative DR(PDR)with associated vitreous hemorrhage,retinal detachment,iris neovascularization,glaucoma and irreversible blindness.In vitreous samples of human patients with PDR,we found elevated levels of hypoxia inducible factor 1 alpha(HIF1α).HIFs are transcription factors that promote hypoxia adaptation and have important functional roles in a wide range of ischemic and inflammatory diseases.To recreate the human PDR phenotype for a preclinical animal model,we generated a mouse with neuroretinal-specific loss of the von Hippel Lindau tumor suppressor protein,a protein that targets HIF1αfor ubiquitination.We found that the neuroretinal cells in these mice overexpressed HIF1αand developed severe,irreversible ischemic retinopathy that has features of human PDR.Rapid progression of retinopathy in these mutant mice should facilitate the evaluation of therapeutic agents for ischemic and inflammatory blinding disorders.In addition,this model system can be used to manipulate the modulation of the hypoxia signaling pathways,for the treatment of non-ocular ischemic and inflammatory disorders. | Katherine J Wert Vinit B Mahajan Lijuan Zhang Yuanqing Yan Yao Li Joaquin Tosi Chun Wei Hsu Takayuki Nagasaki Kerstin M Janisch Maria B Grant MaryAnn Mahajan Alexander G Bassuk Stephen H Tsang | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 1 |
| 2 | The translationally controlled tumor protein is a novel calcium binding protein of the human placenta and regulates calcium handling in trophoblast cells显示文摘 | Arcuri F Papa S Meini A Carducci A Romagnoli R Bianchi L Riparbelli M G Sanchez J C Palmi M Tosi P Cintorino M | 2005 | Biol Reprod2005，73，4： | 1 |
| 3 | Ionic Sizes and Born Repulsive Parameters in the NaCI - Type Alkali Halides - I 显示文摘 | F G Fumi M P Tosi | 1964 | Phys Chem Solids1964，25，： | 1 |
| 4 | Glare disability and spherical aberration with five foldable intraocular lenses: a prospective randomized study 显示文摘 | Casprini F Balestrazzi A Tosi G M | 2005 | Acta Ophthalmol Scand2005，83，1： | 1 |
| 5 | Ambroxol for prophylaxis and treatment of broncho-pulmonary complications after chest surgery显示文摘 | ROMANINI B M SANDRI M G TOSI M | 1996 | Int J Clin Res1996，2，3： | 1 |
| 6 | Evaluating the efficacy of lysozyme against lactic acid bacteria under different winemaking scenarios显示文摘 | Azzolini M Tosi E Veneri G | 2010 | Efficacy of Lysosyme in Winemaking2010，31，2： | 1 |
| 7 | Genetic and epigenetic alterations of Rb2/p130 tumor suppressor gene in human sporadic retinoblastoma:implications for pathogenesis and therapeutic approach显示文摘 | TOSI G M TRIMARCHI C MACALUSO M | 2005 | Oncogene2005，24，38： | 1 |
| 8 | Flow pat- terns of an air-water mixture at the exit of a micro T- junction 显示文摘 | PUCCETYI G TOSI M PULVIRENTI B | 2015 | Experimental Thermal and Fluid Science2015，67，： | 1 |
| 9 | A theoretical study of the stabilization of the (AlF5^2-) complex anion by alkali counterions显示文摘 | AKDENIZ Z CICEK Z KARAMAN A PASTORE G TOSI M P | 1999 | Z Naturforsch1999，54，： | 1 |
| 10 | Susceptibility of Streptococcus thermophilus to antibiotics 显示文摘 | TOSI L BERRUTI G DANIELSEN M | 2007 | Antonie Van Leeuwenhoek2007，92，1： | 1 |
| 11 | Analysis of the allele-specific expression of the mismatch repair geneMLH1 using a simple DHPLC-based method显示文摘 | Tournier I Raux G Di Fiore F Mar6chal 1 Leclerc C Martin C Wang Q Buisine MP Stoppa- Lyonnet D Olschwang S Frabourg T Tosi M | 2004 | Hum Mutat2004，23，4： | 1 |
| 12 | Ambroxol for prophylaxis and treament of brochopulmonary complications after chest surgery Int显示文摘 | Romanini B M Saandri M G Tosi s m | 1986 | J Clin Pharm Res1986，4，： | 1 |
| 13 | Cross-gainmodulation bandwidth enhancement in semiconductor optical amplifiers by means of detuned optical filter显示文摘 | T G Silveira A L J Teixeira P M N P Monteiro G M Tosi Beleffi | 2005 | Electronics Letters2005，41，13： | 1 |
| 14 | Ionic sizes and born repulsive parameters in the NaCl-Type alkali halides-II 显示文摘 | M P Tosi F G Fumi | 1964 | J Phys Chem Solids1964，25，： | 1 |
| 15 | Choroidal calcification in Bartter syndrome 显示文摘 | Marchini G Tosi R Parolini B Castagna G Zarbin M | 1998 | Am J Ophthalmol1998，126，： | 1 |
| 16 | Association between the D19S884 marker at the insulin receptor geng locus and polycystic ovary syndrome 显示文摘 | Villuendas G Escobar M H F Tosi F | 2003 | Fertil Steril2003，，： | 1 |
| 17 | Ionic sizes and bom repulsive parameters in the NaCl-type alkali halides- II 显示文摘 | Tosi M P Fumi F G | 1964 | J Phys Chem Solids1964，25，： | 1 |
| 18 | Histological, physiological and biochemical interactions between vesicular-arbuscular mycorrhizae and thielaviopsis basicola in tobacco plants显示文摘 | Giovannetti M Tosi L Della Torre G | 1991 | Phytopathology1991，131，： | 1 |
| 19 | Evaluating the efficacy oflysozyme against lactic add bacteria under different winemaking scenarios显示文摘 | AZZOLINI M TOSI E VENERI G | 2010 | South African Journal for Enology & Viticulture2010，31，： | 1 |
| 20 | Ambroxol for prophylaxis and treatment of bronchopulmonary complications after chest surgery显示文摘 | ROMANINI B M SANDRI M G TOSI M | 1986 | Int J Clin Pharmacol Res1986，16，2： | 1 |
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