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| 1 | Predisposing factors for positive D-Xylose breath test for evaluation of small intestinal bacterial overgrowth:A retrospective study of 932 patients显示文摘AIM: To investigate, in the largest cohort to date, patient characteristics and associated risk factors for developing small intestinal bacterial overgrowth(SIBO) using the D-Xylose breath test(XBT).METHODS: We performed a retrospective crosssectional study to analyze patient characteristics who underwent the XBT for evaluation of SIBO. Diagnostic testing with the XBT was performed based on a clinical suspicion for SIBO in patients with symptoms of bloating, abdominal pain, abdominal distension, weight loss, diarrhea, and/or constipation. Consecutive electronicmedical records of 932 patients who completed the XBT at the University of Florida between 2005 and 2009 were reviewed. A two-way Analysis of Variance(ANOVA) was used to test for several associations including age, gender, and body mass index(BMI) with a +XBT. A two-way ANOVA was also performed to control for the differences and interaction with age and between genders. A similar analysis was repeated for BMI. Associations between medical conditions and prior surgical histories were conducted using the Mantel-Haenszel method for 2 by 2 contingency tables, stratified for gender. Reported odds ratio estimates reflect the odds of the prevalence of a condition within the +XBT group to that of the-XBT group. P values of less than 0.05(two-sided) were considered statistically significant.RESULTS: In the 932 consecutive eligible subjects studied, 513 had a positive XBT. A positive association was found between female gender and a positive XBT(P = 0.0025), and females with a positive test were, on average, greater than 5 years older than those with a negative test(P = 0.024). The mean BMI of positive XBT subjects was normal(24.5) and significantly lower than the subjects with a negative XBT(29.5)(P = 0.0050). A positive XBT was associated with gastroesophageal reflux disease(GERD)(OR = 1.35; 95%CI: 1.02-1.80, P = 0.04), peptic ulcer disease(PUD)(OR = 2.61; 95%CI: 1.48-4.59, P < 0.01), gastroparesis(GP)(OR = 2.04; 95%CI: 1.21-3.41, P < 0.01) and steroid use(OR = 1.35; 95%CI: 1.02-1.80, P = 0.01). Irritable bowel syndrome, independent protonpump inhibitor(PPI) usage, or previous abdominal surgery was not significantly associated with a positive XBT. No single subdivision by gender or PPI use was associated with a significant difference in the odds ratios between any of the subsets. CONCLUSION: Female gender, lower BMI, steroid use, PUD, GERD(independent of PPI use), and GP were more prevalent in patients with SIBO, determined by a positive XBT. Increasing age was associated with SIBO in females, but not in males. | Richard A Schatz Qing Zhang Nilesh Lodhia Jonathan Shuster Phillip P Toskes Baharak Moshiree | 2015 | World Journal of Gastroenterology2015，21，15： | 4 |
| 2 | Continued experience with the xylose breath test: Evidence that the mall bowel culture as a gold standard for bacterial overgrowth may be tarnished 显示文摘 | TILLMAN R KING C TOSKES P | 1981 | Gastroenterology1981，80，6： | 1 |
| 3 | Hypefiipid emiepancreatitis显示文摘 | Toskes P P | 1990 | Gastroenterol Clin North Am1990，19，1： | 1 |
| 4 | Allium sativum (garlic) and cancer prevention显示文摘 | LAU B H S TADI P P TOSK J M | 1990 | Nutr Res1990，10，8： | 1 |
| 5 | Hyperlipidemic pancreatitis显示文摘 | TOSKES P P | 1990 | Gastroenterol Clin North Am1990，19，4： | 1 |
| 6 | Medical therapy for chronic pancreatitis pain显示文摘 | SINGH V V TOSKES P P | 2003 | Curr Gastroenterol Rep2003，5，2： | 1 |
| 7 | Hypefiipid emiepancreatifis显示文摘 | Toskes P P | 1990 | Gastroenterol Clin North Am1990，19，1： | 1 |
| 8 | Medical therapy for chronic pancreatitis pain 显示文摘 | Singh V V Toskes P P | 2003 | Curr Gastroenterol Rep2003，5，2： | 1 |
| 9 | Solanapyrones E-G, anatialga metobolites produced by a marine fungus显示文摘 | Jenkins K M Toske S G Jensen P R | 1998 | Phytochemistry1998，49，8： | 1 |
| 10 | Aspergillamides A and B:modified cytotoxic tripeptides produced by a marine fungus of the genus Aspergillus显示文摘 | Toske S G Jensen P R Kauffman C A | 1998 | Tetrahedron1998，54，13： | 1 |
| 11 | Continued experiencewith the xylose- breath test: Evidence that themall bowel cultureas agold standardfor bacterial overgrowthmay be tarnished显示文摘 | Tillman R King C Toskes P | 1981 | Gastroenterology1981，80，6： | 1 |
| 12 | Hyperlipidemic pancreatitis显示文摘 | Toskes P P | 1990 | Gastroenterol Clin North Am1990，19，： | 1 |
| 13 | Solanapyrones E-G,antialgal metabolites produced by a marine fungus显示文摘 | Jenkins K M Toske S G and Jensen P R | 1998 | Phytochem istry1998，49，8： | 1 |
| 14 | Hyperlipidemie pancreatitis显示文摘 | Toskes P P | 1990 | Gastroemerol Clin NorthAm1990，19，1： | 1 |
| 15 | Hyperlipidemic Pancreatitis显示文摘 | TOSKES P P | 1990 | Gastroenterol Clin North Am1990，19，： | 1 |
| 16 | Hyperlipidemic pancreatitis 显示文摘 | Toskes P P | 1990 | Gastroenterol Clin North Am1990，19，： | 1 |
| 17 | Allium sativum(garlic)and cancerprevention显示文摘 | LAU B H S TADI P P TOSK J M | 1990 | Nutr Res1990，10，8： | 1 |
| 18 | Small bowel bacterial overgrowth:presentation,diagnosis and treatment显示文摘 | Singh V V Toskes P P | | 0，，01： | 1 |
| 19 | Hyperlipidemic pancreatitis显示文摘 | Toskes P P | 1990 | Gastroenterol Clin North Am1990，19，： | 1 |
| 20 | Chronic pancreatitis显示文摘 | Draganov P Toskes PP | 2002 | Curr Opin Gastroenterol2002，18，5： | 1 |
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