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| 1 | Fatty liver in hepatitis C patients post-sustained virological response with direct-acting antivirals显示文摘AIM To determine steatosis and fibrosis prevalence in hepatitis C patients after a sustained virological response achieved with direct-acting antivirals.METHODS Transient elastography with controlled attenuation parameter(CAP) was used to assess hepatic steatosis post-sustained virological response(SVR);the CAP technology was not available in the United States at study initiation.Liver stiffness/fibrosis was measured before and 47 wk after treatment completion.Patients with genotype 3 and patients with cirrhosis were excluded.RESULTS One hundred and one patients were included in the study.Post-SVR there were decreases from baseline in alanine aminotransferase(ALT)(63.1 to 17.8 U/L),aspartate aminotransferase(51.8 to 21.5 U/L) and fibrosis score(7.4 to 6.1 k Pa)(P < 0.05).Post-SVR,48 patients(47.5%) had steatosis on CAP;of these,6.25% had advanced fibrosis.Patients with steatosis had higher body mass index(29.0 vs 26.1 kg/m2),glucose(107.8 vs 96.6 mg/d L),ALT(20.4 vs 15.3 mg/d L),CAP score(296.3 vs 212.4 d B/m) and fibrosis score(7.0 vs 5.3 k Pa);P < 0.05.Interestingly,compared to baseline,both patients with and without steatosis had change in fibrosis score post-SVR(7.7 k Pa vs 7.0 k Pa and 7.0 k Pa vs 5.3 k Pa);alternatively,(P < 0.05) and therefore patients with steatosis continued to have clinically significant stiffness(≥ 7 k Pa).CONCLUSION Fatty liver is very common in hepatitis C virus(HCV) patients post-SVR.These patients continue to have elevated mean fibrosis score(≥ 7 k Pa) compared to those without fatty liver;some have advanced fibrosis.Long term follow up is needed to assess steatosis and fibrosis in HCV patients post-SVR. | Mazen Noureddin Micaela M Wong Tsuyoshi Todo Shelly C Lu Arun J Sanyal Edward A Mena | 2018 | World Journal of Gastroenterology2018，24，11： | 6 |
| 2 | Variants of dopamine and serotonin candidate genes as predictors of response to risperidone treatment in first-episode schizophrenia显示文摘 | Masashi Ikeda Yoshio Yamanouchi Yoko Kinoshita Tsuyoshi Kitajima Reiji Yoshimura Shuji Hashimoto Michael C O&rsquor Donovan Jun Nakamura Norio Ozaki Nakao Iwata | 2008 | Pharmacogenomics2008，，10： | 1 |
| 3 | Pitavastatin inhibits remnant lipoprotein- induced maerophagc foam cell fi)rmation through ApoP,48 receptor - dependent mechanism 显示文摘 | Akio K Mariko T Tsuyoshi C | 2005 | Arterioscler Thromb Vase Biol2005，25，2： | 1 |
| 4 | A study into cold rotary forming of precision metal components显示文摘 | WONG C C DANNO A TONG K K TSUYOSHI M LIM K B YONG M S | 2007 | SIMTech Technical Reports2007，8，2： | 1 |
| 5 | A quantitative water resource planning and management model for an industrial park level 显示文摘 | Yong Geng Raymond C?te Fujita Tsuyoshi | 2007 | Regional Environmental Change2007，，7： | 1 |
| 6 | Dietary protein, but not carbohydrate,is a primary determinant ofthe onset of stroke in stroke-prone spontaneously hypertensive rats 显示文摘 | TSUYOSHI C TATSUKI I MASAKI T | 2009 | Stroke2009，40，： | 1 |
| 7 | Hydrothermal pretreatment and enzymatic saccharification of corn stover for efficient ethanol production显示文摘 | Badal C Saha Tsuyoshi Yoshida Michael A Cotta | 2013 | Industrial Crops and Products2013，44，1： | 1 |
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