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| 1 | No association between cyclooxygenase-2 and uridine diphosphate glucuronosyltransferase 1A6 genetic polymorphisms and colon cancer risk显示文摘AIM:To investigate the association of variations in the cyclooxygenase-2(COX2) and uridine diphosphate glucuronosyltransferase 1A6(UGT1A6) genes and non-steroidal anti-inflammatory drugs(NSAIDs) use with risk of colon cancer.METHODS:NSAIDs,which are known to reduce the risk of colon cancer,act directly on COX2 and reduce its activity.Epidemiological studies have associated variations in the COX2 gene with colon cancer risk,but others were unable to replicate this finding.Similarly,enzymes in the UGT1A6 gene have been demonstrated to modify the therapeutic effect of NSAIDs on colon adenomas.Polymorphisms in the UGT1A6 gene have been statistically shown to interact with NSAID intake to influence risk of developing colon adenomas,but not colon cancer.Here we examined the association of tagging single nucleotide polymorphisms(SNPs) in the COX2 and UGT1A6 genes,and their interaction with NSAID consumption,on risk of colon cancer in a population of 422 colon cancer cases and 481 population controls.RESULTS:No SNP in either gene was individually statistically significantly associated with colon cancer,nor did they statistically significantly change the protective effect of NSAID consumption in our sample.Like others,we were unable to replicate the association of variants in the COX2 gene with colon cancer risk(P > 0.05),and we did not observe that these variants modify the protective effect of NSAIDs(P > 0.05).We were able to confirm the lack of association of variants in UGT1A6 with colon cancer risk,although further studies will have to be conducted to confirm the association of these variants with colon adenomas.CONCLUSION:Our study does not support a role of COX2 and UGT1A6 genetic variations in the development of colon cancer. | Cheryl L Thompson Sarah J Plummer Alona Merkulova Iona Cheng Thomas C Tucker Graham Casey Li Li | 2009 | World Journal of Gastroenterology2009，15，18： | 11 |
| 2 | No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer显示文摘AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based casecontrol study of incident colon cancer individuals (n= 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene. | Lynette S Phillips Cheryl L Thompson Alona Merkulova Sarah J Plummer Thomas C Tucker Graham Case Li Li | 2009 | World Journal of Gastroenterology2009，15，30： | 2 |
| 3 | Characterization of Sodium Carboxymethylcellulose Gelatincomplex Coacervation by Viscosity,Turbidity and Coacervate Wet Weight and Volume Measurements显示文摘 | Koh G L Tucker L G | 1988 | Journal of Pharmacy and Pharmacology1988，40，4： | 1 |
| 4 | Orthothotropic closure approximations for flow-induced fiber orientation显示文摘 | Cintra J S Tucker C L | 1995 | J Rheol1995，39，6： | 1 |
| 5 | Interpersonal suicide risk for Allael'icarl Indians:investigating thwarted belongingness and perceived burden someness 显示文摘 | o' KEEFE V M WINGATE L R TUCKER R P | 2013 | Cultur Divers Ethnic Minor Psychol2013，26，： | 1 |
| 6 | Estimation of the spatial distribu- tion of target cells for radiation pneumonitis in mouse lung 显示文摘 | Tucker S L Liao Z X Travis E L | 1997 | Int J Radiat Oncol Biol Phys1997，38，5： | 1 |
| 7 | Lessons learned in- translating research evidence on early intervention programs into clinical care显示文摘 | Tucker S Klotzbach L Olsen G | 2006 | MCN2006，31，5： | 1 |
| 8 | Detection and plasma pharmacokinetics of an anti-vescuisr endothelial growth factor oligonucleotide eptsmer (NX1838) in rhesus monkeys显示文摘 | Chen L Judkins MB | 1999 | J Chromatogr B Biomed Sci Appl1999，732，1： | 1 |
| 9 | Telomerase activity in the differentiation of benign and malignant adrenal tumors显示文摘 | Teng L Tucker O Malchoff C | 1998 | Surgery1998，124，6： | 1 |
| 10 | Variations in northern vegetation activity inferred from satellite data of vegetation index during 1981 to 1999 显示文摘 | Zhou L M Tucker C J Kaufmann R K | 2001 | Journal of Geophysical Research2001，106，20： | 1 |
| 11 | Lessons learned in translating re-search evidence on early intervention pro- grams into clinical care显示文摘 | Tucker S Klotzbach L Olsen G | 2006 | MCN2006，31，5： | 1 |
| 12 | Variations in northern vegetation activity inferred from satellite data of vegetation index during 1981 to 1999显示文摘 | Zbou L M Tucker C J Kaufmann R K | 2001 | Journal of Geophysical Research2001，106，20： | 1 |
| 13 | A mechanism to explain the selection of the hepatitis e antigen-negative mutant during chronic hepatitis B virus infection 显示文摘 | Frelin L Wahlstrom T Tucker AE | 2009 | J Virol2009，83，3： | 1 |
| 14 | Teaching and physics education research: bridging the gap显示文摘 | James M Fraser Anneke L Timan Kelly Miller Jason E Dowd Laura Tucker Eric Mazur | 2014 | Reports on Progress in Physics2014，，3： | 1 |
| 15 | Permanent pacemaker for atrioventricular conduction block after operative repair of perimembranous ventricular septal defect 显示文摘 | TUCKER E M LEE A JOHN L | 2007 | J Am Coll Cardiol2007，50，12： | 1 |
| 16 | 显示文摘 | Tucker M C Jacobson C P De Jonghe L C | 2006 | Journal of Power Sources2006，160，： | 1 |
| 17 | Exercise as an intervention for enhancing subjective well'being in an HIV- I Population显示文摘 | LOX C L McAULEY E TUCKER R S | 1995 | JSEP1995，17，4： | 1 |
| 18 | Differential effects of aging and insulin-like growth factor-1 on synapses in CAI of rat hippocampus显示文摘 | Shi L Linville MC Tucker EW | 2005 | Cereb Cortex2005，15，5： | 1 |
| 19 | Locoregional recurrence after doxorubicin- based chemotherapy and postmastectomy: Implications for breast cancer patients with early-stage disease and predictors for recurrence after postmastectomy radiation显示文摘 | WOODWARD W A STROM E A TUCKER S L | 2003 | Int J Radiat Oncol Biol Phys2003，57，2： | 1 |
| 20 | Computer simulation of single-phase nanocrystalline permanent magnets显示文摘 | Griffiths M K Bishop J E L Tucker J W | 1998 | J of Magn Magn Mater1998，183，： | 1 |
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