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| 1 | Diversity of Helicobacter pylori genotypes in Iranian patients with different gastroduodenal disorders显示文摘AIM:To investigate the diversity of Helicobacter pylori(H.pylori)genotypes and correlations with disease outcomes in an Iranian population with different gastroduodenal disorders.METHODS:Isolates of H.pylori from patients with different gastroduodenal disorders were analyzed after culture and identification by phenotypic and genotypic methods.Genomic DNA was extracted with the QIAamp DNA mini kit(Qiagen,Germany).After DNA extraction,genotyping was done for cagA,vacA(s and m regions),iceA(iceA1,iceA2)and babA with specific primers for each allele using polymerase chain reaction(PCR).All patients’pathologic and clinical data and their relation with known genotypes were analyzed by using SPSS version 19.0 software.2test and Fisher’s exact test were used to assess relationships between categorical variables.The level of statistical significance was set at P<0.05.RESULTS:A total of 71 isolates from 177 patients with different gastroduodenal disorders were obtained.Based on analysis of the cagA gene(positive or negative),vacA s-region(s1or s2),vacA m-region(m1or m2),iceA allelic type(iceA1and iceA2)and babA gene(positive or negative),twenty different genotypic combinations were recognized.The prevalence of cagA,vacA s1,vacA s2,vacA m1,vacA m2,iceA1,iceA2,iceA1+iceA2and babA were 62%,78.9%,19.7%,21.1%,78.9%,15.5%,22.5%,40.8%and 95.8%,respectively.Interestingly,evaluation of PCR results for cagA in 6 patients showed simultaneous existence of cagA variants according to their size diversities that proposed mixed infection in these patients.The most prevalent genotype in cagA-positive isolates was cagA+/vacAs1m2/iceA1+A2/babA+and in cagA-negative isolates was cagA-/vacAs1m2/iceA-/babA+.There were no relationships between the studied genes and histo-pathological findings(H.pylori density,neutrophil activity,lymphoid aggregation in lamina propria and glandular atrophy).The strains which carry cagA,vacAs1/m1,iceA2and babA genes showed significant associations with severe active chronic gastritis(P=0.011,0.025,0.020 and 0.031,respectively).The vacAs1genotype had significant correlation with the presence of the cagA gene(P=0.013).Also,babA genotype showed associations with cagA(P=0.024).In the combined genotypes,only cagA+/vacAs1m1/iceA2/babA+genotype showed correlation with severe active chronic gastritis(P=0.025).CONCLUSION:This genotyping panel can be a useful tool for detection of virulent H.pylori isolates and can provide valuable guidance for prediction of the clinical outcomes. | Farzam Vaziri Shahin Najar Peerayeh Masoud Alebouyeh Tabassom Mirzaei Yoshio Yamaoka Mahsa Molaei Nader Maghsoudi Mohammad Reza Zali | 2013 | World Journal of Gastroenterology2013，19，34： | 5 |
| 2 | Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study显示文摘 | Laurent Beaugerie Nicole Brousse Anne Marie Bouvier Jean Frédéric Colombel Marc Lémann Jacques Cosnes Xavier Hébuterne Antoine Cortot Yoram Bouhnik Jean Pierre Gendre Tabassome Simon Marc Maynadié Olivier Hermine Jean Faivre Fabrice Carrat | 2009 | The Lancet . 2009 (9701)2009，，： | 4 |
| 3 | Increased Risk for Nonmelanoma Skin Cancers in Patients Who Receive Thiopurines for Inflammatory Bowel Disease显示文摘 | Laurent Peyrin–Biroulet Kiarash Khosrotehrani Fabrice Carrat Anne–Marie Bouvier Jean–Baptiste Chevaux Tabassome Simon Frank Carbonnel Jean–Frédéric Colombel Jean–Louis Dupas Philippe Godeberge Jean–Pierre Hugot Marc Lémann Stéphane Nahon Jean–Marc Sabaté | 2011 | Gastroenterology2011，，5： | 3 |
| 4 | 轻型缺血性卒中或短暂性脑缺血发作的早期双联抗血小板治疗显示文摘王拥军及同事探讨了应用双联抗血小板治疗预防卒中复发或短暂性脑缺血发作的最新证据。轻型缺血性卒中和短暂性脑缺血发作(TIA)患者在头几周内有较高的卒中及其他血管事件的复发风险(5%~11.7%严。双联抗血小板治疗,包括氯吡格雷和阿司匹林,是减少卒中复发的有效治疗策略Magic Group的专家小组(http://gffzz25d7f5dd9bdf4c9eh0qkwxk0q0xqf60o0.ffgz.tsg.suse.edu.cn/)最近在The BMJ中发表了一个强烈的快速推荐建议,即对于轻型缺血性卒中和TIA患者应在症状出现24小时内开始双联抗血小板治疗,并持续10~21天3。 | 王拥军 S. Claiborne Johnston Philip M Bath James C. Grotta 潘岳松 Pierre Amarenco 王伊龙 Tabassome Simon Jong Sung Kim Jiann-Shing Jeng 刘丽萍 林毅 Ka Sing Lawrence Wong David Wang 李昊 | 2019 | 英国医学杂志中文版2019，22，5： | 2 |
| 5 | Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6Chi and Ly6Clo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice显示文摘 | Christophe Combadière Stéphane Potteaux Mathieu Rodero Tabassome Simon Adeline Pezard Bruno Esposito Régine Merval Amanda Proudfoot Alain Tedgui Ziad Mallat | 2008 | Circulation2008，，13： | 2 |
| 6 | Excess primary intestinal lymphoproliferative disorders in patients with inflammatory bowel disease显示文摘 | Harry Sokol Laurent Beaugerie Marc Maynadié David Laharie Jean‐Louis Dupas Bernard Flourié Eric Lerebours Laurent Peyrin‐Biroulet Matthieu Allez Tabassome Simon Fabrice Carrat Nicole Brousse | 2012 | Inflamm Bowel Dis2012，，11： | 1 |
| 7 | Retinol binding protein 4 and prediction of incident coro-nary events in healthy men and women显示文摘 | ZIAD MALLAT TABASSOME SIMON JOELLE BENESSIANO | 2008 | J Clin EndocrinMetab2008，1210，10： | 1 |
| 8 | Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study显示文摘 | Laurent Beaugerie Nicole Brousse Anne Marie Bouvier Jean Frédéric Colombel Marc Lémann Jacques Cosnes Xavier Hébuterne Antoine Cortot Yoram Bouhnik Jean Pierre Gendre Tabassome Simon Marc Maynadié Olivier Hermine Jean Faivre Fabrice Carrat | 2009 | The Lancet2009，，9701： | 1 |
| 9 | Genetic Determinants of Response to Clopi-dogrel and Cardiovascular Events显示文摘 | Tabassome Simon Celine Verstuyit Murielle Mary-Krause | 2009 | N Engl J Med2009，360，： | 1 |
| 10 | Genetic variants in ABCB1 and CYP2CI9 and cardiovascular outcomes after treatment with clopidogrel and prasugrel in the TRITON-TIMI 38 trial: a pharmacogenetic analysis显示文摘 | Tabassome Simon Stephen D Wiviott Elliott M Antman | 2010 | Lancet2010，376，： | 1 |
| 11 | Lymphoproliferative disorders in patients receiving thiopurines for inflammatory bowel disease: a prospective observational cohort study显示文摘 | Laurent Beaugerie Nicole Brousse Anne Marie Bouvier Jean Frédéric Colombel Marc Lémann Jacques Cosnes Xavier Hébuterne Antoine Cortot Yoram Bouhnik Jean Pierre Gendre Tabassome Simon Marc Maynadié Olivier Hermine Jean Faivre Fabrice Carrat | 2009 | The Lancet2009，，9701： | 1 |
| 12 | Clinical events as a function of proton pump inhibitor use, clopidogrel use, and cytochrome P450 2C19 genotype in a large nationwide cohort of acute myocardial in- farction: results from the french registry of acute st-elevation and non st-elevation myocardial infarction(FAST-MI) registry显示文摘 | TABASSOME SIMON PHILIPPE GABRIEL STEG MARTINE GILARD | 2011 | Circulation2011，123，： | 1 |
| 13 | Retinol binding protein 4 and prediction of incidentcoronary events in healthy men and women显示文摘 | ZIAD MALLAT TABASSOME SIMON JOELLE BENESSIANO | 2008 | J Clin EndocrinMetab2008，1210，10： | 1 |
| 14 | Increased Risk for Nonmelanoma Skin Cancers in Patients Who Receive Thiopurines for Inflammatory Bowel Disease显示文摘 | Laurent Peyrin–Biroulet Kiarash Khosrotehrani Fabrice Carrat Anne–Marie Bouvier Jean–Baptiste Chevaux Tabassome Simon Frank Carbonnel Jean–Frédéric Colombel Jean–Louis Dupas Philippe Godeberge Jean–Pierre Hugot Marc Lémann Stéphane Nahon Jean–Marc Sabaté | 2011 | Gastroenterology2011，，5： | 1 |
| 15 | Pharmacology of antithrombotic drugs: an assessment of oral antiplatelet and anticoagulant treatments显示文摘 | Jessica L Mega Tabassome Simon | 2015 | The Lancet . 2015 (9990)2015，，9990： | 1 |
| 16 | Genetic Detenninants of Response to clopidogrel and Cardiovascular E- vents显示文摘 | TABASSOME S I CELINE V MURIELLE M K | 2009 | N Engl J Med2009，360，4： | 1 |
| 17 | Bond durability of the resin-bonded and silane treated ceramic surface显示文摘 | Tabassom Hooshmand Richard van Noort Alireza Keshvad | 2002 | Dent Mater2002，18，： | 1 |
| 18 | 针灸治疗难治性三叉神经痛疗效评价显示文摘目的评价针刺对难治性三叉神经痛(TN)患者疼痛的影响。方法共14例难治性TN患者接受针刺干预,每周3次,共10次。每次治疗持续30 min。于干预前及干预3、7、14、21天及1个月后随访时采用视觉模拟量表(VAS)评分评价患者疼痛程度。数据采用SPSS 18.0软件进行分析。结果观察对象平均年龄(59.4±13.2)岁。VAS评分随着治疗次数增加而下降。结果显示干预前、干预3天与干预14天、21天及1个月随访时的VAS评分差值均有统计学差异(P<0.05)。结论针刺治疗能减轻难治性TN患者的疼痛。多次针刺治疗后能产生镇痛效果。 | Fatemeh Lavaee Farideh Rafiee Zahra Tabassom Zahra Ranjbar | 2021 | Journal of Acupuncture and Tuina Science2021，19，6： | 1 |
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