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| 1 | CoolClot,a novel hemostatic agent for controlling life-threatening arterial bleeding显示文摘BACKGROUND:Uncontrolled bleeding is the first leading cause of preventable death in the battlefield and the 2nd cause of mortality in civil accidents.Incompressible hemorrhage control is among the interventions that drastically increase the survival rate in wound individuals.We have previously shown that a certain mixture of bentonite and zeolite minerals can significantly decrease the bleeding in rats.METHODS:In this study,nine healthy hybrid dogs were selected and after induction of anesthesia with ether,either arterial puncture by a needle or arteriotomy was performed on both groin regions of the dogs.For control arteries(either the right or left femoral artery),only pressure by sterilized gauze was performed,while for the femoral arteries of the opposite side,our invented hemostatic agent,namely CoolClot,was topically used before applying the pressure.In the second stage of the study,to assess the coagulation time,blood samples were collected from 10 volunteer students.RESULTS:CoolClot significantly decreased the bleeding time in animals whose femoral arteries were cut or punctured.In the human phase of the study,the mean coagulation time in control blood samples was 253.4+44.1 seconds,whereas it was 149.5+50.0,162.3±74.6 and 143.4±114.6seconds,respectively in blood samples treated with bentonite,zeolite and CoolClot(P<0.05).CONCLUSIONS:As controlling bleeding after a life-threatening arterial damage is critical for increasing the chance of survival,the results obtained in this study indicate the significant efficacy of CoolClot in shortening the bleeding time.Our experiments also indicate that CoolClot can significantly reduce the clotting time in human blood samples. | SMJ Mortazavi A Tavasoli M Atefi N Tanide N Radpey P Roshan-shomal H Moradi S Taeb | 2013 | World Journal of Emergency Medicine2013，4，2： | 2 |
| 2 | Utilization of Copper Slag in the Cement Industry显示文摘 | Taeb A Faghihi S | 2002 | ZKG International2002，55，4： | 1 |
| 3 | Spontaneous hemopneumothorax显示文摘 | Taebe S Kanazawa H Yamazaki Y et a1 | 1996 | Ann Rhorae Surg1996，62，7： | 1 |
| 4 | Study of correlations and relations between plant yieldand quantitative and qualitative other traits in safflower显示文摘 | Bagheri A Yazdi S B Taeb M | | Iranian Journal of Agricultural Sciences0，32，2： | 1 |
| 5 | miRNA-95 mediates radioresistance in tumors by targeting the sphingalipid phosphatase SGPP1 显示文摘 | Huang X Taeb S Jahangiri S | 2013 | Cancer Res2013，73，23： | 1 |
| 6 | Spontaneous hemopneumothorax显示文摘 | Taebe S Kanazawa H Yamazaki Y | 1996 | Ann Thorac Surg1996，62，7： | 1 |
| 7 | Fischer-Tropsch synthesis over Ru promoted Co/γ-Al2O3 catalysts in a CSTR 显示文摘 | Hosseini S A Taeb A Feyzi F | 2004 | Catalysis Communications2004，5，： | 1 |
| 8 | Study of correlations and relations between plant yield and quantitative and qualitative other traits in safflower显示文摘 | Bagheri A Yazdi S B Taeb M | 2001 | Iranian Journal of Agricultural Sciences2001，32，2： | 1 |
| 9 | Study of correlations and relations between plant yield and quantitative and qualitative other traits in safflower显示文摘 | BAGHERI A YAZDI S B TAEB M | 2001 | Iranian Journal of Agricultural Sciences2001，32，2： | 1 |
| 10 | mi RNA-95 mediates radioresistance in tumors by targeting the sphingolipid phosphatase SGPP1显示文摘 | Huang X Taeb S Jahangiri S | 2013 | Cancer Res2013，73，23： | 1 |
| 11 | Fischer- Tropsch synthesis over Ru promoted Co/γ/ - Al2O3 catalysts in a CSTR 显示文摘 | Hosseini S A Taeb A Feyzi F | 2004 | Catalysis Communications2004，5，： | 1 |
| 12 | Crystal structure of bis (1,10-phenanthroline) dinitratocadmium 显示文摘 | Tadjarodi A Taeb A Ng S W | 2001 | Main Group Met Chem2001，24，： | 1 |
| 13 | Alterations of visual reaction time and short term memory in military radar personnel显示文摘 | Mortazavi SM Taeb S Dehghan N | 2013 | Iran J Public Health2013，42，4： | 1 |
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