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| 1 | 帕博利珠单抗联合以铂类为基础的化疗治疗非小细胞肺癌合并稳定性脑转移患者的结局:KEYNOTE-021、-189和-407研究的汇总分析显示文摘背景与目的此项探索性分析回顾评价了晚期非小细胞肺癌(non-small cell lung cancer,NSCLC)患者的结局,旨在确定基线时合并脑转移是否会影响一线应用帕博利珠单抗联合化疗(pembrolizumab plus chemotherapy,PC)比对单用化疗的疗效。患者和方法对KEYNOTE-021队列G(非鳞癌)、KEYNOTE-189(非鳞癌)和KEYNOTE-407(鳞癌)三项研究晚期NSCLC患者的数据进行汇总分析。患者接受含铂两药化疗和/或35个周期帕博利珠单抗治疗(每3周200 mg)。所有研究均纳入了经治或初治的稳定性脑转移患者(KEYNOTE-189与KEYNOTE-407研究纳入初治脑转移患者)。经治的脑转移患者已处于病情稳定的状态≥2周(KEYNOTE-021队列G患者≥4周),无新发或脑转移病灶扩大的证据且入组前至少3天以上未使用激素。初治的无症状脑转移患者需定期接受脑部影像学检查。结果共纳入1298例患者,其中171例有基线脑转移,1127例无脑转移。两组的中位随访时间(范围)在数据截止时分别为10.9(0.1-35.1)个月和11.0(0.1-34.9)个月。合并脑转移和无脑转移患者的总生存期[0.48(95%CI:0.32-0.70)和0.63(95%CI:0.53-0.75)]和无进展生存期[0.44(95%CI:0.31-0.62)和0.55(95%CI:0.48-0.63)]的风险比(PC/化疗)相似。合并脑转移的患者中,PC组和单用化疗组患者的中位总生存期分别为18.8个月和7.6个月,中位无进展生存期分别为6.9个月和4.1个月。无论是否合并脑转移,PC组患者的客观缓解率都高于单用化疗组,且缓解持续时间有显著延长。合并脑转移的患者中,PC组与单用化疗组的治疗相关不良事件发生率分别为88.2%和82.8%;而无脑转移的患者中,两组治疗相关不良事件的发生率分别为94.5%和90.6%。结论无论是否合并脑转移,与单用化疗相比,帕博利珠单抗联合以铂类为基础的组织学特异性化疗可改善所有PD-L1亚组的临床结局,其中包括PD-L1肿瘤比例评分<1%的患者,并且在晚期NSCLC患者中安全性良好。该方案是晚期NSCLC初治患者的标准方案,并可用于合并稳定性脑转移的患者。 | 周清(翻译校对) Steven F Powell Delvys Rodríguez-Abreu Corey J Langer Ali Tafreshi Luis Paz-Ares Hans-Georg Kopp Jeronimo Rodríguez-Cid Dariusz M Kowalski Ying Cheng Takayasu Kurata Mark M Awad Jinaxin Lin Bin Zhao M Catherine Pietanza Bilal Piperdi Marina C Garassino | 2022 | 中国肺癌杂志2022，25，1： | 6 |
| 2 | Proposing in- dicators for the development of nursing care quality in Iran 显示文摘 | Pazargadi M Tafreshi MZ Abedsaeedi Z | 2008 | Int Nurs Rev2008，55，4： | 1 |
| 3 | Supe- rhydrophobic surfaces: From the lotus to the submarine 显示文摘 | SAMAHA M A TAFRESHI H V GAD-EL-HAK M | 2012 | Comptes Rendus Mecanique2012，340，12： | 1 |
| 4 | A review of the investi gational antiarrhythmic agent dronedarone显示文摘 | TAFRESHI M J ROWLES J | 2007 | J Card iovasc Pharmacol Ther2007，12，： | 1 |
| 5 | Repeated Loadingof Soil Containing Granulated Rubber and Multiple Geocell Layers显示文摘 | Tafreshi S N M Khalaj O Dawson A R | 2014 | Geotextiles and Geomembranes2014，42，1： | 1 |
| 6 | Comparison of bearing capacity of a strip footing on sand with geocell and with planar forms of geotextile reinforcement 显示文摘 | Tafreshi S N M Dawson A R | 2010 | Geotextiles and Geomembranes2010，28，1： | 1 |
| 7 | Characterization and evaluation of fire Protection foams显示文摘 | Tafreshi A M Ftoyd R | 1998 | NIST1998，，48： | 1 |
| 8 | Frequency and management of thrombocytopenia with the glycoprotein Ⅱb/ Ⅲa receptor antagonists 显示文摘 | HUXTABLE L M TAFRESHI M J RAKKAR A N | 2006 | Am J Cardiol2006，97，3： | 1 |
| 9 | Integration of distributed energy resources into low voltage grid: a market-based multiperiod optimization model显示文摘 | Elahe M Moghaddas Tafreshi S M | 2010 | Electric Power Systems Research2010，80，4： | 1 |
| 10 | Bearing Capacity of a Square Model Footing on Sand Reinforced with Shredded Tire - an Experimental Investigation显示文摘 | Tafreshi S N M Norouzi A H | 2012 | Construction and Building Materials2012，35，： | 1 |
| 11 | Frequency and management of thrombocytopenia with the glycoproteinⅡb/Ⅲa receptor antagonists显示文摘 | HUXTABLE L M TAFRESHI M J RAKKAR A N | 2006 | Am J Cardiol2006，97，： | 1 |
| 12 | Carbonic anhy- drase IX as an imaging and therapeutic target for tumors and metastases显示文摘 | Tafreshi N K Lloyd M C Bui M M | 2014 | Subcell Biochem2014，75，： | 1 |
| 13 | A mammaglohin-A tar geting agent for noninvasive detection of breast cancer metastasis in lymph nodes 显示文摘 | Tafreshi N K Enkemann S A Bui M M Lloyd M C Abrahams D Huynh A S | 2011 | Cancer Res2011，71，： | 1 |
| 14 | Dunaliella biotechnology:methodsand applicatons显示文摘 | Hosseini Tafreshi A Shariati M | 2009 | J Appl Microbiol2009，107，1： | 1 |
| 15 | Safety of ultrasound guided thoraeentesis in patients receiving mechanical ventilation 显示文摘 | Mayo PH Goltz HR Tafreshi M | 2004 | Chest2004，125，3： | 1 |
| 16 | Proposing indicators for the development of nursing care quality in Iran显示文摘 | Pazargadi M Tafreshi MZ Abedsaeedi Z | 2008 | Int Nurs Rev2008，55，4： | 1 |
| 17 | Combination of clopidogre and protonpump inhibitors:implications for cilnians显示文摘 | Tran M Tafreshi J Pai RG | 2010 | J Cardiovasc Phar-macol Ther2010，15，4： | 1 |
| 18 | Superhydrophobie surfaces:From the lotus leaf to the submarine显示文摘 | Samaha m A Tafreshi H V Gad-el-hak M | 2012 | CR Math2012，340，12： | 1 |
| 19 | Development of a multiplex nested consensus PCR for detection and identification of major human herpesviruses in CNS infections显示文摘 | Tafreshi NK Sadeghizadeh M Amini-Bavil-Olyaee S | 2005 | J Clin Virol2005，32，4： | 1 |
| 20 | Comparison of bearingcapacity of a strip footing on sand with geocell and with planarforms of geotextile reinforcement显示文摘 | TAFRESHI S N M DAWSON A R | 2010 | Geotextiles and Geomembranes2010，28，： | 1 |
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