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| 1 | Differential Expression of Two Cytosolic Ascorbate Peroxidases and Two Superoxide Dismutase Genes in Response to Abiotic Stress in Rice显示文摘Superoxide dismutase (SOD) and ascorbate peroxidase (APX) play central roles in the pathway for scavenging reactive oxygen species in plants, thereby contributing to the tolerance against abiotic stress. Here we report the responses of cytosolic SOD (cSOD; sodCc1 and sodCc2) and cytosolic APX (cAPX; OsAPX1 and OsAPX2) genes to oxidative and abiotic stress in rice. RNA blot analyses revealed that methyl viologen treatment caused a more prominent induction of cAPXs compared with cSODs, and hydrogen peroxide treatment induced the expression of cAPXs whereas cSODs were not affected. These results suggest that cAPXs play more important roles in defense against oxidative stress compared with cSODs. It is noted that cSODs and cAPXs showed coordinate response to abscisic acid treatment which induced both sodCc1 and OsAPX2. However, cSODs and cAPXs responded differentially to drought, salt and chilling stress, which indicates that cSOD and cAPX genes are expressed differentially in response to oxidative and abiotic stress in rice. | Shigeto MORITA Shinya NAKATANI Tomokazu KOSHIBA Takehiro MASUMURA Yasunari OGIHARA Kunisuke TANAKA | 2011 | Rice science2011，18，3： | 3 |
| 2 | CD14 upregulation as a distinct feature of non-alcoholic fatty liver disease after pancreatoduodenectomy显示文摘AIM:To investigate the pathogenesis of non-alcoholic fatty liver disease(NAFLD)after pancreatoduodenectomy(PD).METHODS:A cohort of 82 patients who underwent PD at Okayama University Hospital between 2003 and 2009 was enrolled and the clinicopathological features were compared between patients with and without NAFLD after PD.Computed tomography(CT)images were evaluated every 6 mo after PD for follow-up.Hepatic steatosis was diagnosed on CT when hepatic attenuation values were 40 Hounsfield units.Liver biopsy was performed for 4 of 30 patients with NAFLD after PD who consented to undergo biopsies.To compare NAFLD after PD with NAFLD associated with metabolic syndrome,liver samples were obtained from 10 patients with NAFLD associated with metabolic syndrome [fatty liver,n = 5;non-alcoholic steatohepatitis(NASH),n = 5] by percutaneous ultrasonography-guided liver biopsy.Double-fluorescence immunohistochemistry was applied to examine CD14 expression as a marker of lipopolysaccharide(LPS)-sensitized macrophage cells(Kupffer cells)in liver biopsy specimens.RESULTS:The incidence of postoperative NAFLD was 36.6%(30/82).Univariate analysis identified cancer of the pancreatic head,sex,diameter of the main pancreatic duct,and dissection of the nerve plexus as factors associated with the development of NAFLD after PD.Those patients who developed NAFLD after PD demonstrated significantly decreased levels of serum albumin,total protein,cholesterol and triglycerides compared to patients without NAFLD after PD,but no glucose intolerance or insulin resistance.Liver biopsy was performed in four patients with NAFLD after PD.All four patients showed moderate-to-severe steatosis and NASH was diagnosed in two.Numbers of cells positive for CD68(a marker of Kupffer cells)and CD14(a marker of LPSsensitized Kupffer cells)were counted in all biopsy specimens.The number of CD68+ cells in specimens of NAFLD after PD was significantly increased from that in specimens of NAFLD associated with metabolic syndrome specimens,which indicated the presence of significantly more Kupffer cells in NAFLD after PD than in NAFLD associated with metabolic syndrome.Similarly,more CD14+ cells,namely,LPS-sensitized Kupffer cells,were observed in NAFLD after PD than in NAFLD associated with metabolic syndrome.Regarding NASH,more CD68+ cells and CD14+ cells were observed in NASH after PD specimens than in NASH associated with metabolic syndrome.This showed that more Kupffer cells and more LPS-sensitized Kupffer cells were present in NASH after PD than in NASH associated with metabolic syndrome.These observations suggest that after PD,Kupffer cells and LPS-sensitized Kupffer cells were significantly upregulated,not only in NASH,but also in simple fatty liver.CONCLUSION:NAFLD after PD is characterized by both malnutrition and the up-regulation of CD14 on Kupffer cells.Gut-derived endotoxin appears central to the development of NAFLD after PD. | Daisuke Satoh Takahito Yagi Takeshi Nagasaka Susumu Shinoura Yuzo Umeda Ryuichi Yoshida Masashi Utsumi Takehiro Tanaka Hiroshi Sadamori Toshiyoshi Fujiwara | 2013 | World Journal of Hepatology2013，5，4： | 3 |
| 3 | Management of gastric mucosa-associated lymphoid tissue lymphoma in patients with extra copies of the MALT1 gene显示文摘AIM To identify the clinical features of gastric mucosaassociated lymphoid tissue(MALT) lymphoma with extra copies of MALT1.METHODS This is a multi-centered,retrospective study. We reviewed 146 patients with MALT lymphoma in the stomach who underwent fluorescence in situ hybridization analysis for t(11;18) translocation. Patients were subdivided into patients without t(11;18) translocation or extra copies of MALT1(Group A,n = 88),patients with t(11;18) translocation(Group B,n = 27),and patients with extra copies of MALT1(Group C,n = 31). The clinical background,treatment,and outcomes of each group were investigated.RESULTS Groups A and C showed slight female predominance,whereas Group B showed slight male predominance. Mean ages and clinical stages at lymphoma diagnosis were not different between groups. Complete response was obtained in 61 patients in Group A(69.3%),22 in Group B(81.5%),and 21 in Group C(67.7%). Helicobacter pylori(H. pylori) eradication alone resulted in complete remission in 44 patients in Group A and 13 in Group C. In Group B,14 patients underwent radiotherapy alone,which resulted in lymphoma disappearance. Although the difference was not statistically significant,event-free survival in Group C tended to be inferior to that in Group A(P = 0.10).CONCLUSION Patients with t(11;18) translocation should be treated differently from others. Patients with extra copies of MALT1 could be initially treated with H. pylori eradication,similar to patients without t(11;18) translocation or extra copies of MALT1. | Masaya Iwamuro Ryuta Takenaka Masahiro Nakagawa Yuki Moritou Shunsuke Saito Shinichiro Hori Tomoki Inaba Yoshinari Kawai Tatsuya Toyokawa Takehiro Tanaka Tadashi Yoshino Hiroyuki Okada | 2017 | World Journal of Gastroenterology2017，23，33： | 3 |
| 4 | Clinicopathological characteristics of human epidermal growth factor receptor 2-positive Barrett's adenocarcinoma显示文摘AIM:To compare the clinicopathological characteristics of human epidermal growth factor receptor 2 (HER2)-positive and HER2-negative Barrett's adenocarcinoma in Japan. METHODS:We performed immunohistochemical analysis of HER2 in 30 samples taken from patients with Barrett's adenocarcinoma and dual color in situ hybridization in cases showing 2+ reactions. We compared the clinicopathological characteristics of HER2-positive and HER2-negative patients.RESULTS:HER2 positivity was identified in 8 (27%) carcinoma samples. We found that HER2 expression was associated with p53 overexpression (100% vs 52.6% in pT1 tumor; 100% vs 54.5% in all stage tumor, P < 0.05) and protruding lesions at the early disease stage. There was no association between the mucin phenotype of the carcinomas and prognosis. HER2 expression and low clinical stage were unexpectedly different between Barrett's adenocarcinoma patients and gastric cancer patients, but the macroscopic features may be associated with earlier diagnosis in these patients. CONCLUSION:Our results suggest that HER2-positive Barrett's adenocarcinomas are associated with p53 overexpression and lesion protrusion at the early disease stage. | Takehiro Tanaka Atsushi Fujimura Koichi Ichimura Hiroyuki Yanai Yasuharu Sato Katsuyohi Takata Hiroyuki Okada Seiji Kawano Shunsuke Tanabe Tadashi Yoshino | 2012 | World Journal of Gastroenterology2012，18，43： | 2 |
| 5 | Validation study of postoperative liver failure and mortality risk scores after liver resection for perihilar cholangiocarcinoma显示文摘Background:Surgery for perihilar cholangiocarcinoma(PHCC)remains a challenging procedure with high morbidity and mortality.The Academic Medical Center(Amsterdam UMC)and Memorial Sloan Kettering Cancer Center proposed a postoperative mortality risk score(POMRS)and post-hepatectomy liver failure score(PHLFS)to predict patient outcomes.This study aimed to validate the POMRS and PHLFS for PHCC patients at Hokkaido University.Methods:Medical records of 260 consecutive PHCC patients who had undergone major hepatectomy with extrahepatic bile duct resection without pancreaticoduodenectomy at Hokkaido University between March 2001 and November 2018 were evaluated to validate the PHLFS and POMRS.Results:The observed risks for PHLF were 13.7%,24.5%,and 39.8%for the low-risk,intermediate-risk,and high-risk groups,respectively,in the study cohort.A receiver-operator characteristic(ROC)analysis revealed that the PHLFS had moderate predictive value,with an analysis under the curve(AUC)value of 0.62.Mortality rates based on the POMRS were 1.7%,5%,and 5.1%for the low-risk,intermediate-risk,and high-risk groups,respectively.The ROC analysis demonstrated an AUC value of 0.58.Conclusions:This external validation study showed that for PHLFS the threshold for discrimination in an Eastern cohort was reached(AUC>0.6),but it would require optimization of the model before use in clinical practice is acceptable.The POMRS were not applicable in the eastern cohort.Further external validation is recommended. | Takehiro Noji Satoko Uemura Jimme KWiggers Kimitaka Tanaka Yoshitsugu Nakanishi Toshimichi Asano Toru Nakamura Takahiro Tsuchikawa Keisuke Okamura Pim BOlthof William RJarnagin Thomas Mvan Gulik Satoshi Hirano | 2022 | Hepatobiliary Surgery and Nutrition2022，11，3： | 2 |
| 6 | Review of the diagnosis of gastrointestinal lanthanum deposition显示文摘Lanthanum carbonate is used for treatment of hyperphosphatemia mostly in patients with chronic renal failure.Although lanthanum carbonate is safe,recently,lanthanum deposition in the gastrointestinal mucosa of patients has been reported in the literature.This review provides an overview of gastroduodenal lanthanum deposition and focuses on disease's endoscopic,radiological,and histological features,prevalence,and outcome,by reviewing relevant clinical studies,case reports,and basic research findings,to better understand the endoscopic manifestation of gastrointestinal lanthanum deposition.The possible relationship between gastric lanthanum deposition pattern and gastric mucosal atrophy is also illustrated;in patients without gastric mucosal atrophy,gastric lanthanum deposition appears as diffuse white lesions in the posterior wall and lesser curvature of the gastric body.In the gastric mucosa with atrophy,lanthanum-related lesions likely appear as annular or granular whitish lesions.Moreover,these white lesions are probably more frequently observed in the lower part of the stomach,where intestinal metaplasia begins. | Masaya Iwamuro Haruo Urata Takehiro Tanaka Hiroyuki Okada | 2020 | World Journal of Gastroenterology2020，26，13： | 2 |
| 7 | Study on Pilot Injection of DI Diesel Engine Using Common-railinjection System显示文摘 | Takehiro Tanaka Akihiro Ando | 2002 | JSAE Review2002，，23： | 1 |
| 8 | Cloning and characterization of a cDNA encoding a rice 13 kDa prolamin显示文摘 | Takehiro Masumura Takashi Hibino Kunitomo Kidzu Norihiro Mitsukawa Kunisuke Tanaka Shoji Fujii | 1990 | MGG Molecular & General Genetics1990，，1： | 1 |
| 9 | Anti-oxidative effects of d -allose, a rare sugar, on ischemia-reperfusion damage following focal cerebral ischemia in rat显示文摘 | Takehiro Nakamura Shinji Tanaka Kazuyuki Hirooka Tetsuhiko Toyoshima Nobuyuki Kawai Takashi Tamiya Fumio Shiraga Masaaki Tokuda Richard F. Keep Toshifumi Itano Osamu Miyamoto | 2010 | Neuroscience Letters2010，，1： | 1 |
| 10 | Cytokines Involved in CNS Manifestations Caused by Mycoplasma pneumoniae显示文摘 | Mitsuo Narita Hiroshi Tanaka Takehiro Togashi Shosaku Abe | 2005 | Pediatric Neurology2005，，2： | 1 |
| 11 | Externalization of Saw-Tooth Architecture in Small Serrated Polyps Implies the Presence of Methylation of IGFBP7显示文摘 | Eisuke Kaji Toshio Uraoka Jun Kato Sakiko Hiraoka Hideyuki Suzuki Mitsuhiro Akita Shunsuke Saito Takehiro Tanaka Nobuya Ohara Kazuhide Yamamoto | 2012 | Digestive Diseases and Sciences2012，，5： | 1 |
| 12 | Circulating tumor DNA dynamics analysis in a xenograft mouse model with esophageal squamous cell carcinoma显示文摘BACKGROUND It remains unclear which factors,such as tumor volume and tumor invasion,influence circulating tumor DNA(ctDNA),and the origin of ctDNA in liquid biopsy is always problematic.To use liquid biopsies clinically,it will be very important to address these questions.AIM To assess the origin of ctDNA,clarify the dynamics of ctDNA levels,assess ctDNA levels by using a xenograft mouse after treatment,and to determine whether tumor volume and invasion are related to ctDNA levels.METHODS Tumor xenotransplants were established by inoculating BALB/c-nu/nu mice with the TE11 cell line.Groups of mice were injected with xenografts at two or four sites and sacrificed at the appropriate time point after xenotransplantation for ctDNA analysis.Analysis of ctDNA was performed by droplet digital PCR,using the human telomerase reverse transcriptase(hTERT)gene.RESULTS Mice given two-site xenografts were sacrificed for ctDNA at week 4 and week 8.No hTERT was detected at week 4,but it was detected at week 8.However,in four-site xenograft mice,hTERT was detected both at week 4 and week 6.These experiments revealed that both tumor invasion and tumor volume were asso ciated with the detection of ctDNA.In resection experiments,hTERT was detected at resection,but had decreased by 6 h,and was no longer detected 1 and 3 d after resection.CONCLUSION We clarified the origin and dynamics of ctDNA,showing that tumor volume is an important factor.We also found that when the tumor was completely resected,ctDNA was absent after one or more days. | Hiroyuki Terasawa Hideaki Kinugasa Kazuhiro Nouso Shumpei Yamamoto Mami Hirai Takehiro Tanaka Akinobu Takaki Hiroyuki Okada | 2021 | World Journal of Gastroenterology2021，27，41： | 1 |
| 13 | Sufficient PplX production for PDT even with short contact time of topically applied 5-ALA in rabbit tongues显示文摘 | Takehiro Oura Hideo Tanaka Yuji morimoto | 2008 | Lasers Med Sci2008，23，4： | 1 |
| 14 | Study on pilot injection of DI diesel engine using common-rail injection system 显示文摘 | Takehiro Tanaka Akihiro Ando | 2002 | JSAE Review2002，23，2： | 1 |
| 15 | Study on Pilot Injection of DI Diesel Engine Using Common Rail Injection System显示文摘 | Takehiro Tanaka Akihiro Ando | 2002 | JSAE Review2002，23，： | 1 |
| 16 | Study on pilot injection of DI diesel engine using common-rail injection system 显示文摘 | Takehiro Tanaka Akihiro Ando | 2002 | JSAE Review2002，23，： | 1 |
| 17 | Review of lymphoma in the duodenum: An update of diagnosis and management显示文摘The presentation,subtype,and macroscopic images of lymphoma vary depending on the site of the tumor within the gastrointestinal tract.We searched PubMed for publications between January 1,2012 and October 10,2022,and retrieved 130 articles relating to duodenal lymphoma.A further 22 articles were added based on the manual screening of relevant articles,yielding 152 articles for full-text review.The most predominant primary duodenal lymphoma was follicular lymphoma.In this review,we provide an update of the diagnosis and management of representative lymphoma subtypes occurring in the duodenum:Follicular lymphoma,diffuse large B-cell lymphoma,extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue,mantle cell lymphoma,and Tcell lymphomas. | Masaya Iwamuro Takehiro Tanaka Hiroyuki Okada | 2023 | World Journal of Gastroenterology2023，29，12： | 0 |
| 18 | Application of electron microscopy in gastroenterology显示文摘Electron microscopy has long been used in research in the fields of life sciences and materials sciences.Transmission and scanning electron microscopy and energy-dispersive X-ray spectroscopy(EDX)analyses have also been performed in the field of gastroenterology.Electron microscopy and EDX enable(1)Observation of ultrastructural differences in esophageal epithelial cells in patients with gastroesophageal reflux and eosinophilic esophagitis;(2)Detection of lanthanum deposition in the stomach and duodenum;(3)Ultrastructural and elemental analyses of enteroliths and bezoars;(4)Detection and characterization of microorganisms in the gastrointestinal tract;(5)Diagnosis of gastrointestinal tumors with neuroendocrine differentiation;and(6)Analysis of gold nanoparticles potentially used in endoscopic photodynamic therapy.This review aims to foster a better understanding of electron microscopy applications by reviewing relevant clinical studies,basic research findings,and the state of current research carried out in gastroenterology science. | Masaya Iwamuro Haruo Urata Takehiro Tanaka Hiroyuki Okada | 2022 | World Journal of Gastrointestinal Pathophysiology2022，13，2： | 0 |
| 19 | Natural history of major complications in hepatitis C virus-related cirrhosis evaluated by per-rectal portal scintigraphy显示文摘AIM: To examine the correlation between the porto-systemic hypertension evaluated by portal shunt index (PSI) and life-threatening complications, Including hepatocellular carcinoma (HCC), liver failure (Child-Pugh stage progression),and esophagogastric varices.METHODS: Two hundred and twelve consecutive subjects with HCV-related cirrhosis (LC-C) underwent per-rectal portal scintigraphy. They were allocated into three groups aocording to their PSI: group Ⅰ, PSI≤10%; group Ⅱ, 10% | Etsushi Kawamura Daiki Habu Takehiro Hayashi Ai Oe Jin Kotani Hirotaka Ishizu Kenji Torii Joji Kawabe Wakaba Fukushima Takashi Tanaka Shuhei Nishiguchi Susumu Shiomi | 2005 | World Journal of Gastroenterology2005，11，25： | 0 |
| 20 | Transcatheter arterial embolization for traumatic injury to the pharyngeal branch of the ascending pharyngeal artery:Two case reports显示文摘BACKGROUND The ascending pharyngeal artery(APhA)comprises the pharyngeal trunk(PT)and neuromeningeal trunk.The PT feeds the nasopharynx and adjacent tissue,which potentially connects with the sphenopalatine artery(SPA),branched from the internal maxillary artery(IMA).Due to its location deep inside the body,the PT is rarely injured by trauma.Here,we present two cases that underwent transcatheter arterial embolization(TAE)of the PT of the APhA due to trauma and iatrogenic procedure.CASE SUMMARY Case 1 is a 49-year-old Japanese woman who underwent transoral endoscopy under sedation for a medical check-up.The nasal airway was inserted as glossoptosis occurred during sedation.Bleeding from the nasopharynx was observed during the endoscopic procedure.As the bleeding continued,the patient was referred to our hospital for further treatment.Contrast-enhanced computed tomography(CT)demonstrated extravasation in the nasopharynx originating from the right Rosenmuller fossa.TAE was performed and the extravasation disappeared after embolization.Case 2 is a 28-year-old Japanese woman who fell from the sixth floor of a building and was transported to our hospital.Contrastenhanced CT demonstrated a complex facial fracture accompanying extravasation in the left pterygopalatine fossa to the nasopharynx.Angiography demonstrated an irregular third portion of the IMA.As angiography after TAE of the IMA demonstrated extravasation from the PT of the APhA,additional TAE to the artery was performed.The bleeding stopped after the procedure.CONCLUSION Radiologists should be aware that the PT of the APhA can be a bleeding source,which has a potential connection with the SPA. | Daisuke Yunaiyama Yuki Takara Takehiro Kobayashi Mika Muraki Taro Tanaka Mitsuru Okubo Toru Saguchi Motoki Nakai Kazuhiro Saito Kiyoaki Tsukahara Yuri Ishii Hiroshi Homma | 2022 | World Journal of Clinical Cases2022，10，32： | 0 |
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