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| 1 | Axitinib plus gemcitabine versus placebo plus gemcitabine in patients with advanced pancreatic adenocarcinoma: a double-blind randomised phase 3 study显示文摘 | Hedy L Kindler Tatsuya Ioka Dirk J Richel Jaafar Bennouna Richard Létourneau Takuji Okusaka Akihiro Funakoshi Junji Furuse Young Suk Park Shinichi Ohkawa Gregory M Springett Harpreet S Wasan Peter C Trask Paul Bycott Alejandro D Ricart Sinil Kim Eric Van | 2011 | Lancet Oncology2011，，3： | 4 |
| 2 | Role of observation of live cases done by Japanese experts in the acquisition of ESD skills by a western endoscopist显示文摘AIM:To evaluate the role of observation of experts performing endoscopic submucosal dissection(ESD)in the acquisition of ESD skills.METHODS:This prospective study is documenting the learning curve of one Western endoscopist.The study consisted of three periods.In the first period(preobservation),the trainee performed ESDs in animal models in his home institution in the United States.The second period(observation)consisted of visit to Japan and observation of live ESD cases done by experts.The observation of cases occurred over a 5-wk period.During the third period(post-observation),the trainee performed ESD in animal models in a similar fashion as in the first period.Three animal models were used:live40-50 kg Yorkshire pig,explanted pig stomach model,and explanted pig rectum model.The outcomes from the ESDs done in the animal models before and after observation of live human cases(main study intervention)were compared.Statistical analysis of the data included:Fisher’s exact test to compare distributions of a categorical variable,Wilcoxon rank sum test to compare distributions of a continuous variable between the two groups(pre-observation and post-observation),and Kruskal-Wallis test to evaluate the impact of lesion location and type of model(ex-vivo vs live pig)on lesion removal time.RESULTS:The trainee performed 38 ESDs in animal model(29 pre-observation/9 post-observation).The removal times post-observation were significantly shorter than those pre-observation(32.7±15.0 min vs 63.5±9.8 min,P<0.001).To minimize the impact of improving physician skill,the 9 lesions post-observation were compared to the last 9 lesions pre-observation and the removal times remained significantly shorter(32.7±15.0 min vs 61.0±7.4 min,P=0.0011).Regression analysis showed that ESD observation significantly reduced removal time when controlling for the sequence of lesion removal(P=0.025).Furthermore,it was also noted a trend towards decrease in failure to remove lesions and decrease in complications after the period of observation.This study did not find a significant difference in the time needed to remove lesions in different animal models.This finding could have important implications in designing training programs due to the substantial difference in cost between live animal and explanted organ models.The main limitation of this study is that it reflects the experience of a single endoscopist.CONCLUSION:Observation of experts performing ESD over short period of time can significantly contribute to the acquisition of ESD skills. | Peter V Draganov Myron Chang Roxana M Coman Mihir S Wagh Qi An Takuji Gotoda | 2014 | World Journal of Gastroenterology2014，20，16： | 3 |
| 3 | Spatial variability of nitrous oxide emissions and their soil -related determining factors in an agricultural field显示文摘 | Junta Y Takuji S Taku O | 2003 | Journal of Environmental Quality2003，32，： | 1 |
| 4 | Localization of laminin-5 in the epidermal basement membrane 显示文摘 | Takuji M Hiroshi S Akira I | 1996 | J Histochem Cytochem1996，44，： | 1 |
| 5 | Face-to-face Porphyrin Moieties Assembled with Spacing for Pyrazine Recognition in Molecularly Imprinted Polymers 显示文摘 | Jun M Takuji S Yumi S | 2009 | Biosens Bioelectron2009，25，3： | 1 |
| 6 | A novel inflammation- related mouse colon carcinogenesis mode/ induced by azoxymethane and dextran sodium sulfate 显示文摘 | Takuji T Hiroyuki K Rikako S et d | 2003 | Cancer Sci2003，94，11： | 1 |
| 7 | Clinical study and image diagnosis of nasal bone fracture显示文摘 | TAKENORI O NAOHIRO S TAKUJI O | 2002 | Practice Otorhinolaryngologica2002，95，： | 1 |
| 8 | Identification of heading date quantitative trait locus Hd6 and character-ization of its epistatic interactions with Hd2 in rice using advanced backcross progeny 显示文摘 | Yamamoto Lin H Takuji S | 2000 | Genetics2000，154，： | 1 |
| 9 | HD6, a rice quantitative trait locus involved in photoperiod sensit- ivity, encodes the a subunit of protein kinase CK2 显示文摘 | Takahashi Y Shomura A Takuji S | 2001 | PNAS2001，98，14： | 1 |
| 10 | Fine mapping and characterization of quantitative trait loci Hd4 and Hd5 controlling heading date in rice 显示文摘 | Takahashi Y Shomura A Takuji S | 2003 | Breeding Science2003，53，： | 1 |
| 11 | 显示文摘 | Takuji S Kohei I Seimei S | 2004 | Applied Surface Science2004，237，14： | 1 |
| 12 | Chemoprevention of carcinogenesis by organoselenium compounds 显示文摘 | Shigeyuki S Takuji T Karam E B | 2000 | Journal of Health Science2000，46，6： | 1 |
| 13 | Pulmonary macrophage transplantation therapy显示文摘 | Takuji S Paritha A Takuro S | 2014 | Nature2014，514，7523： | 1 |
| 14 | Clinical study and image diagnosis of nasal bone fracture显示文摘 | Naohiro S Takuji O | 2002 | Practice Otorhinolaryngologica2002，95，1： | 1 |
| 15 | Chemoprevention of carcinogenesis by organoselenium compounds显示文摘 | Shigeyuki S Takuji T Karam E B | 2000 | Journal of Health Science2000，46，6： | 1 |
| 16 | Degradation of aqueous phenol by simultaneous use of ozone with silica-gel and zeolite显示文摘 | Noriaki S Takuji Y Daisuke Y | 2007 | Chemical Engineering and Processing2007，46，： | 1 |
| 17 | Thermal and mechanical properties of perovskite-type barium hafnate 显示文摘 | TAKUJI M K KEN K S SHINSUKE Y K | 2006 | J Alloy Compd2006，407，12： | 1 |
| 18 | Deactivation of ZSM 5 zeolite during catalytic steam cracking of n-hexane显示文摘 | Aritomo Y Takuji I Koichi S el al | 2014 | Fuel Processing Technology2014，19，9： | 1 |
| 19 | Detection of early gastric cancer:misunderstanding the role of mass screening显示文摘 | HARUHISA S TAKUJI G MITSURU S | 2006 | Gastric Cancer2006，9，： | 1 |
| 20 | Preparation and characterization of soap-free carboxylated polystyrene latexes 显示文摘 | Kazuyuki S Takuji O | 1976 | J Appl Polym Sci1976，20，7： | 1 |
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