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| 1 | Evaluation of chemopreventive effect of Fumaria indica against N-nitrosodiethylamine and CCl_4-induced hepatocellular carcinoma in Wistar rats显示文摘Objective:To investigation the chemopreventive potential of Fumaria indica(F.indica) extract(FIE) on N-nitrosodiethylamine and CCl4-induced hepatocarcinogenesis in Wislar rats.Methods:The experimental animals were divided into six groups(n=6).Hepatocellular carcinoma was induced by single intraperitoneal injection of N-nitrosodiethylamine(NDEA) in normal saline at a dose of 200 mg/kg body weight followed by weekly subcutaneous injections of CCl4(3 mL/kg/week) for 6 weeks,as the promoter of carcinogenic effect.After administration of the carcinogen,200 and 400 mg/kg of FIE were administered orally once a day throughout the study.At the end of 20 weeks,the body weight,liver weight and relative liver weight were measured.The percentage of nodule incidence and liver cancer markers such as aspartate transaminase(AST),alanine transaminase(ALT),alkaline phosphatase(ALP),γ-glutamyl transferase(γ-GT),total bilirubin level(TBL),α-feto protein(AFP) and carcinoembryonic antigen were estimated along with histopathological investigation in experimental groups of rats. Results:Obtained results demonstrated that the cotreatment with FIE significantly prevented the decrease of the body weight and also increased in relative liver weight caused by NDEA. The treatment with FIE significantly reduced the nodule incidence and nodule multiplicity in the rats after NDEA administration.The levels of liver cancer markers such as AST,ALT,ALP,γ-glutamyl transferase,TBL,AFP and carcinoembryonic antigen were substantially increased by NDEA treatment.However,FIE treatment significantly reduced the liver injury and restored the entire liver cancer markers.Histological observations of liver tissues too correlated with the biochemical observations.Conclusions:These finding powerfully supports that F.indica exert chemopreventive effect by suppressing the tumor burden and restoring the activities of hepatic cancer marker enzymes on NDEA and CCl4-induced hepatocarcinogenesis in Wistar rats. | Talib Hussain Hefazat H Siddiqui Sheeba Fareed M Vijayakumar Chandana V Rao | 2012 | Asian Pacific Journal of Tropical Medicine2012，5，8： | 3 |
| 2 | A pentaplex PCR assay for the rapid detection of methicillinresistant Staphylococcus aureus and PantonValentine Leuocidin显示文摘 | AlTalib H Yean C Y AlKhateeb A | 2009 | BMC Microbiol2009，9，： | 1 |
| 3 | Statistical Deformable Bone Models for Robust 3D Surface Extrapolation from Sparse Data 显示文摘 | Rajamani M Styner H Talib | 2007 | Medical Image Analysis2007，，11： | 1 |
| 4 | Information filtering for ultrasound based real-time registration显示文摘 | Talib H Peterhans M Garda J | 2011 | IEEE Trans liomed Eng2011，58，3： | 1 |
| 5 | Evidence for incorporation of free-floating cells as a mechanism of serosal healing 显示文摘 | Adam J F Sarah E H Talib AI-M | 2002 | J Cell Sci2002，115，7： | 1 |
| 6 | Ballistic impact performance of Kevlar-29 and AlzO3 powder/epoxy targets under high velocity impact显示文摘 | Abu Talib A R Abbud L H Ali A | 2012 | Mater Des2012，35，： | 1 |
| 7 | An overview of Malaysian food industry: the opportunity and quality aspects显示文摘 | TALIB H H A ALI K A M | 2009 | Pakistan Journal of Nutrition2009，8，5： | 1 |
| 8 | Facile synthesis of gold nanohexagons on graphene templates in Raman spectroscopy for biosensing cancer and cancer stem cells显示文摘 | MANIKANDAN M NASSER ABDELHAMID H TALIB A | 2014 | Biosensors and Bioelectronics2014，55，： | 1 |
| 9 | Film thickness effects on calibrations of a narrowband thermochromic liquid crystal显示文摘 | ABDULLAH N TALIB A R A SAIAH H R M | 2009 | Experimental Thermal and Fluid Science2009，33，4： | 1 |
| 10 | Facile Synthesis of Gold Nanohexagons on Graphene Templates in Raman Spectroscopy for Biosensing Cancer and Cancer Stem Gells 显示文摘 | Manikandan M Abdelhamid H N Talib A | 2014 | Biosensors & Bioelectronics2014，55，5663： | 1 |
| 11 | Microstructural characteristics on the surface and subsurface of semimetallic automotive friction materials during braking process 显示文摘 | Talib R J Muchtar A Azhari C H | 2003 | J Mater Proc Teeh2003，140，： | 1 |
| 12 | Microstructural characteristics on the surface and subsurface of semimetallic automotive friction materials during braking process显示文摘 | R J Talib A Muchtar C H Azhari | 2003 | Journal of Materials Processing Technology2003，140，13： | 1 |
| 13 | A convenient synthesis of alkyl and aryl substituted bis-1,3,4-oxadiazoles 显示文摘 | TALIB AL SASAKIK H T | 1990 | Synthetic Communications1990，20，12： | 1 |
| 14 | Increased phospholipase A2 activity in schizophrenia with absent response to niacin 显示文摘 | Tavares H Yacubian J Talib LL | 2003 | Schizophr Res2003，61，1： | 1 |
| 15 | Vascular smooth muscle cell apoptosis induces interleukin-1-directed inflam-mation effects of hyperlipidemia-mediated inhibition of phago-cytosis显示文摘 | Clarke M C H Talib S Figg N L | | 0，，2： | 1 |
| 16 | Enhancing saltand-pepper noise removal in binary images of engineering drawing显示文摘 | Al-Khaffaf H S M Talib A Z Salam R A | 2009 | IEICE Transactions on Information and Systems2009，92，4： | 1 |
| 17 | Heterosis and combining ability for quality traits in forage sorghum显示文摘 | Mohammed M I Talib N H | 2008 | Australian Journal of Basic and Applied Sciences2008，2，1： | 1 |
| 18 | Utility of intraple- ural streptokinase in management of chronic empyemas显示文摘 | Talib S H Verma G R Arshad M | 2003 | J Assoc Physicians India2003，51，： | 1 |
| 19 | Microstructural characteristics on the surface and subsurface of semimetallic automotive friction materials during braking process显示文摘 | Talib R J Muchtar A Azhari C H | 2003 | J Mater Process Tech2003，140，： | 1 |
| 20 | Enhancing salt- and-pepper noise removal in binary images of engineering drawing显示文摘 | AI-Khaffaf H S M Talib A Z Salam R A | 2009 | IEICE Transactions on Information and Sys- tems2009，92，4： | 1 |
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